Adult Thymus Contains FoxN1− Epithelial Stem Cells that Are Bipotent for Medullary and Cortical Thymic Epithelial Lineages

Autor: Bruno Kyewski, Thomas G. Hofmann, Paula Klug, Sonja Matt, Fabian Brunk, Ahmet Ucar, Olga Ucar

Publikováno v: Immunity

Summary Within the thymus, two major thymic epithelial cell (TEC) subsets—cortical and medullary TECs—provide unique structural and functional niches for T cell development and establishment of central tolerance. Both lineages are believed to ori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44890e3fbab09da7a1ce653a5570b026
https://doi.org/10.1016/j.immuni.2014.07.005

Exploring the MHC-peptide matrix of central tolerance in the human thymus

Autor: Eleni Adamopoulou, Christina Stoeckle, Ioanna A. Rota, Silvia Tietz, Nina Hillen, Hansjörg Schild, Stefan Stevanovic, Eva Tolosa, Paula Klug, Stefan Tenzer, Madlen Gebhardt, Arthur Melms

Publikováno v: Adamopoulou, Eleni; Tenzer, Stefan; Hillen, Nina; Klug, Paul; Rota, Ioanna A.; Tietz, Silvia; Gebhardt, Madlen; Stevanovic, Stefan; Schild, Hansjörg; Tolosa, Eva; Melms, Arthur; Stoeckle, Christina (2013). Exploring the MHC-peptide matrix of central tolerance in the human thymus. Nature communications, 4(2039), p. 2039. Nature Publishing Group 10.1038/ncomms3039

Ever since it was discovered that central tolerance to self is imposed on developing T cells in the thymus through their interaction with self-peptide major histocompatibility complexes on thymic antigen-presenting cells, immunologists have speculate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48055e15f42de1746c76c62f94bd57d1
https://doi.org/10.1038/ncomms3039