Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Paula Kinsella"'
Autor:
Rachel Chester, Helena Daniell, Pippa Belderson, Carl Wong, Paula Kinsella, Sionnadh McLean, Jonathan Hill, Anirban Banerjee, Felix Naughton
Publikováno v:
Musculoskeletal Science and Practice. :102776
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd29b78acc44a3ea95bcde43e06a4528
https://doi.org/10.1016/j.msksp.2023.102776
https://doi.org/10.1016/j.msksp.2023.102776
Autor:
Grégory Menchon, Lucia Altucci, Giulia Chemi, Simone Brogi, Michel O. Steinmetz, Angela Nebbioso, Natacha Olieric, Daniela M. Zisterer, Francisco de Asís Balaguer, Stefania Butini, Rebecca Amet, Cristina Ulivieri, Alessandro Grillo, Jeff O'Sullivan, Isabel Barasoain, Margherita Brindisi, J. Fernando Díaz, Ettore Novellino, Roberta Spaccapelo, Daniel Lucena-Agell, Ludovica Lopresti, Andrea E. Prota, Sandra Gemma, Mariarosaria Conte, Stefania Magnano, Cosima T. Baldari, Gloria Alfano, Giuseppe Campiani, Paula Kinsella, Tuhina Khan, Lucia Morbidelli, Ola Ibrahim
Publikováno v:
European Journal of Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs endowed with diverse mechanistic properties. Benzoxazepines were recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac07af3e053396026a7fa9fca0f7aa6
http://hdl.handle.net/11391/1447652
http://hdl.handle.net/11391/1447652
Autor:
Niamh M. O’Boyle, Daniela M. Zisterer, Seema M. Nathwani, Mary J. Meegan, Lisa M. Greene, Jade K. Pollock, Paula Kinsella
Publikováno v:
Investigational new drugs. 36(4)
Purpose The combretastatins (CAs) are known to exhibit anti-tumour activity but the underlying mechanism remains to be fully elucidated. Inflammation plays a critical role in altering the function of cancer cells and evasion of cell death and increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f91da082291fecb7a6e523bbb2e7d1e
https://pubmed.ncbi.nlm.nih.gov/29460212
https://pubmed.ncbi.nlm.nih.gov/29460212
Autor:
Colin Clarke, Laura Breen, Mark Leonard, Niall Barron, Sinead T Aherne, Paula Kinsella, Paula Meleady, Padraig Doolan, Martin Clynes, Lin Zhang
Publikováno v:
Journal of Biotechnology. 166:105-113
The selection of clones displaying a high rate of cell growth is an essential component of Chinese hamster ovary (CHO) cell line development. In recent years various "omics" technologies have been utilised to understand the mechanisms underlying biop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4401a82451ca09daa54e1131b3158817
https://doi.org/10.1016/j.jbiotec.2013.04.014
https://doi.org/10.1016/j.jbiotec.2013.04.014
Autor:
Daniela M. Zisterer, D. Clive Williams, Sebastian Bauer, Giuseppe Campiani, Sandra A. Bright, Paula Kinsella, Lisa M. Greene, Jade K. Pollock, Stefania Butini
The C-KIT receptor tyrosine kinase is constitutively activated in the majority of gastrointestinal stromal tumours (GIST). Imatinib (IM) a selective inhibitor of C-KIT, is indicated for the treatment of KIT-positive unresectable and/or metastatic GIS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fd1c3f350f5b972266ea677b556db7
https://www.ncbi.nlm.nih.gov/pubmed/26885657
https://www.ncbi.nlm.nih.gov/pubmed/26885657
Autor:
M. Jansen, Patrick G. Buckley, Leah Alcock, Verena Amberger-Murphy, Rachel Howley, Francesca Brett, Raymond L. Stallings, Josephine Heffernan, Paula Kinsella, Michael A. Farrell
Publikováno v:
Experimental Cell Research. 318:2245-2256
Developing targeted therapies for high grade gliomas (HGG), the most common primary brain tumor in adults, relies largely on glioma cultures. However, it is unclear if HGG tumorigenic signaling pathways are retained under in-vitro conditions. Using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a31ac964681eba552d31ee7fb13069
https://doi.org/10.1016/j.yexcr.2012.06.007
https://doi.org/10.1016/j.yexcr.2012.06.007
Autor:
Colin Clarke, Michael Farrell, Padraig Doolan, Verena Amberger-Murphy, Stephen F. Madden, Paula Kinsella, Martin Clynes, Rachel Howley
Publikováno v:
Experimental Cell Research. 318:641-652
High-grade gliomas (HGG), are the most common aggressive brain tumours in adults. Inhibitors targeting growth factor signalling pathways in glioma have shown a low clinical response rate. To accurately evaluate response to targeted therapies further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12989086229c3f2b5f7f7b78fb5a2d72
https://doi.org/10.1016/j.yexcr.2012.01.014
https://doi.org/10.1016/j.yexcr.2012.01.014
Autor:
Colin Clarke, Finbarr O'Sullivan, Paula Kinsella, Paula Meleady, Niall Barron, Martin Clynes, Mark Leonard, Mark Melville, Padraig Doolan
Publikováno v:
Biotechnology Journal. 7:516-526
Fed batch culture processes are often characterized by decreasing cell culture performance as the process continues, presumably through the depletion of vital nutrients and the accumulation of toxic byproducts. We have similarly observed that cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16879fff30442c765803b89926c9069
https://doi.org/10.1002/biot.201100255
https://doi.org/10.1002/biot.201100255
Autor:
Paula Kinsella, Martin Clynes, Annemarie Larkin, Robert D. Arnold, Michael O'Leary, Robert O'Connor, Donald E. Mager, J. Ballot, Lorraine O'Driscoll, John Crown, David Fennelly, Conor D. Collins, Susan Kennedy
Publikováno v:
Europe PubMed Central
Purpose: Multi-drug resistance mediated by ATP-binding cassette trans-membrane protein pumps is an important cause of cancer treatment failure. Sulindac has been shown to be a competitive substrate for the clinically important resistance protein, mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a89d7b27f8e009e3b6ddacd62c1f18
https://doi.org/10.1007/s00280-006-0240-7
https://doi.org/10.1007/s00280-006-0240-7
Autor:
Michael Devereux, Malachy McCann, Kevin Kavanagh, Paul McCormack, Barry Coyle, Martin Clynes, Paula Kinsella, Robert O'Connor, Vickie McKee, Sinead McKay
Publikováno v:
BioMetals. 17:635-645
The Cu(II) and Ag(I) complexes, [Cu(phendio)3](ClO4)2 x 4H2O and [Ag(phendio)2]ClO4 (phendio = 1,10-phenanthroline-5,6-dione), are prepared in good yield by reacting phendio with the appropriate metal perchlorate salt. The X-ray crystal structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a047901b508ac8544cb7b8a06282ef9
https://doi.org/10.1007/s10534-004-1229-5
https://doi.org/10.1007/s10534-004-1229-5