Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Paula K. Hudson"'
Autor:
Jeannes Angelia, Leah Duong, Faye Yun, Anesa Mesic, Cassandra Yuan, Daniel Carr, Siena Gunari, Paula K. Hudson, Christophe Morisseau, Bruce D. Hammock, Ram Kandasamy, Stevan Pecic
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32262- (2024)
Simultaneous inhibition of soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) with a single small molecule represents a novel therapeutic approach in treating inflammatory pain, since both targets are involved in pain and inflammat
Externí odkaz:
https://doaj.org/article/a9debe63a822457898455455adf78d0e
Autor:
Tiffany Azusada, Elijah Baybay, Jasmine Chi, Paulina Dole, Nancy Gonzalez, Eliu Jaramillo, Thu Nguyen, Ashley Pivaral, Gala Rodriguez, Jacob Zavala, Heyam Zayed, Alex Gaspar, Sam Andino, Khoa Nguyen, Sebastian Pintea, Henry Nguyen, Paula K. Hudson, Stevan Pecic
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101226- (2024)
Acetylcholinesterase (AChE) is an important enzyme that hydrolyzes the neurotransmitter acetylcholine. Inhibiting AChE represents one of the therapeutic strategies for treating the symptoms of Alzheimer’s disease (AD). To date, only several AD drug
Externí odkaz:
https://doaj.org/article/59f6074513fc436bae153fb7f081777b
Publikováno v:
Results in Chemistry, Vol 5, Iss , Pp 100860- (2023)
Symmetrical oxalyl bis(benzenesulfonylhydrazides) [ObBSH] were conveniently prepared by reacting various sulfonyl hydrazides with oxalyl chloride in refluxing tetrahydrofuran (or toluene). The crude products were obtained practically as virtually pur
Externí odkaz:
https://doaj.org/article/a4e4cdfc429b442583d568f1e62a4808
Autor:
Jeannes Angelia, Xiaohui Weng, Aleksei Solomatov, Christopher Chin, Alyssa Fernandez, Paula K. Hudson, Christophe Morisseau, Bruce D. Hammock, Ram Kandasamy, Stevan Pecic
Publikováno v:
Prostaglandins & Other Lipid Mediators. 164:106702
Soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) are potential targets for several diseases. Previous studies have reported that concomitant selective inhibition of sEH and FAAH produced antinociception effects in an animal model
Autor:
Stephanie Wilt, Leah Valencia, Taylor Quintana, Bruce D. Hammock, Paula K. Hudson, Stephanie Sanchez, Sean D. Kodani, Christophe Morisseau, Stevan Pecic, Ram Kandasamy
Publikováno v:
Bioorg Med Chem
Fatty acid amide hydrolase (FAAH) is a membrane protein that hydrolyzes endocannabinoids, and its inhibition produces analgesic and anti-inflammatory effects. The soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) to dihydrox
Autor:
Paula K. Hudson, Thanh N.H. Le, Nghi Vo, Lato Nguyen, Bruce D. Hammock, Mark Rodriguez, Tanya Ly, Stephanie Wilt, Sean D. Kodani, Christophe Morisseau, Stevan Pecic
Publikováno v:
Bioorg Chem
Multitarget-directed ligands are a promising class of drugs for discovering innovative new therapies for difficult to treat diseases. In this study, we designed dual inhibitors targeting the human fatty acid amide hydrolase (FAAH) enzyme and human so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aae9d7b63908dfdf9ba00a3bd9a337e
https://escholarship.org/uc/item/2pb4k5v5
https://escholarship.org/uc/item/2pb4k5v5
Autor:
Stevan Pecic, Shahrokh Lorzadeh, Makar Makarian, Michael Gonzalez, Stephanie M. Salvador, Paula K. Hudson
Publikováno v:
J Mol Struct
In an effort to develop new therapeutic agents to treat Alzheimer's disease, a series of donepezil-based analogs were designed, synthesized using an environmentally friendly route, and biologically evaluated for their inhibitory activity against elec
Publikováno v:
The Journal of Physical Chemistry A. 116:7658-7667
Measurements of the hygroscopic properties of aerosols are needed to better understand the role of aerosols as cloud condensation nuclei. Several techniques have been used to measure deliquescence (solid to liquid) phase transitions in particular. In
Publikováno v:
Atmospheric Environment. 42:5991-5999
Simultaneous size distributions and Fourier transform infrared (FTIR) extinction spectra have been measured for several representative components of mineral dust aerosol (quartz, calcite, and dolomite) in the fine particle size mode ( D =0.1–1 μm)
Publikováno v:
Aerosol Science and Technology. 41:914-924
Heterogeneous reactions of trace gases with mineral dust aerosol not only impact the chemical balance of the atmosphere but also the physicochemical properties of the dust particle and the ability of the particle to act as a cloud condensation nuclei