Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Paula K Greer"'
Autor:
Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Liwei Zhang, Matthew S. Waitkus, Yiping He, Hai Yan
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-12 (2021)
Abstract Diffuse intrinsic pontine gliomas (DIPGs) are high-grade tumors of the brainstem that often occur in children, with a median overall survival of less than one year. Given the fact that DIPGs are resistant to chemotherapy and are not amenable
Externí odkaz:
https://doaj.org/article/e93641f3ec424b8eb9474f91fac10d50
Autor:
Simranjit X. Singh, Rui Yang, Kristen Roso, Landon J. Hansen, Changzheng Du, Lee H. Chen, Paula K. Greer, Christopher J. Pirozzi, Yiping He
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 751 (2022)
Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, pro
Externí odkaz:
https://doaj.org/article/a2f34eeb4d164ba6a4ede50903e97f18
Autor:
Bill H. Diplas, Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, Patrick J. Killela, Daniel B. Loriaux, Eric S. Lipp, Paula K. Greer, Rui Yang, Anthony J. Rizzo, Fausto J. Rodriguez, Allan H. Friedman, Henry S. Friedman, Sizhen Wang, Yiping He, Roger E. McLendon, Darell D. Bigner, Yuchen Jiao, Matthew S. Waitkus, Alan K. Meeker, Hai Yan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying
Externí odkaz:
https://doaj.org/article/dd48eac540f1490a9bb31a4f740711ca
Autor:
Changzheng Du, Landon J. Hansen, Simranjit X. Singh, Feiyifan Wang, Ran Sun, Casey J. Moure, Kristen Roso, Paula K. Greer, Hai Yan, Yiping He
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3199-3211.e5 (2019)
Summary: H2AX safeguards genomic stability in a dose-dependent manner; however, mechanisms governing its proteostasis are poorly understood. Here, we identify a PRMT5-RNF168-SMURF2 cascade that regulates H2AX proteostasis. We show that PRMT5 sustains
Externí odkaz:
https://doaj.org/article/459387299e6e4c179961106be258eabb
Autor:
Hai Yan, Yiping He, Darell D. Bigner, Roger E. McLendon, Ivan Spasojevic, Ping Fan, Cheryl B. Bock, Yu Wang, Jie Feng, Paula K. Greer, Lee H. Chen, Landon J. Hansen, Huishan Zhu, Catherine Y. Wang, Matthew S. Waitkus, Austin B. Carpenter, Christopher J. Pirozzi
Genes displaying more than 2-fold change among IDH1LSL:R132H/WT ad-GFP versus ad-Cre NSCs were selected for pathway analysis by DAVID.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0474a9e4bef24cd9485631bd44f80b72
https://doi.org/10.1158/1541-7786.22517364
https://doi.org/10.1158/1541-7786.22517364
Autor:
Hai Yan, Yiping He, Darell D. Bigner, Roger E. McLendon, Ivan Spasojevic, Ping Fan, Cheryl B. Bock, Yu Wang, Jie Feng, Paula K. Greer, Lee H. Chen, Landon J. Hansen, Huishan Zhu, Catherine Y. Wang, Matthew S. Waitkus, Austin B. Carpenter, Christopher J. Pirozzi
Sequences of primers used for genotyping of animals and for q-RT-PCR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afe34e6d83cdc07de43702046ba43a7
https://doi.org/10.1158/1541-7786.22517370.v1
https://doi.org/10.1158/1541-7786.22517370.v1
Autor:
Hai Yan, Yiping He, Darell D. Bigner, Roger E. McLendon, Ivan Spasojevic, Ping Fan, Cheryl B. Bock, Yu Wang, Jie Feng, Paula K. Greer, Lee H. Chen, Landon J. Hansen, Huishan Zhu, Catherine Y. Wang, Matthew S. Waitkus, Austin B. Carpenter, Christopher J. Pirozzi
Supplementary Figure S1: p53 is upregulated in response to mutant IDH1 induction. Supplementary Figure S2: Hierarchical clustering of top 1% variant genes. Supplementary Figure S3: Further characterization of NSC and brain tumor cell lines. Supplemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d5f4ec0d743f4ea05c09cf83bcbd0a
https://doi.org/10.1158/1541-7786.22517376.v1
https://doi.org/10.1158/1541-7786.22517376.v1
Autor:
Hai Yan, Yiping He, Darell D. Bigner, Roger E. McLendon, Ivan Spasojevic, Ping Fan, Cheryl B. Bock, Yu Wang, Jie Feng, Paula K. Greer, Lee H. Chen, Landon J. Hansen, Huishan Zhu, Catherine Y. Wang, Matthew S. Waitkus, Austin B. Carpenter, Christopher J. Pirozzi
Affymetrix GeneChip Mouse Gene 2.0ST Array used for gene expression profiling. Gene list displays those genes with more than 2-fold change when comparing IDH1LSL:R132H/WT ad-GFP transduced NSCs compared to IDH1LSL:R132H/WT ad-Cre transduced NSCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38f5eb15e10646404cc04771b377f71
https://doi.org/10.1158/1541-7786.22517367
https://doi.org/10.1158/1541-7786.22517367
Autor:
Hai Yan, Matthew S. Waitkus, Yiping He, Liwei Zhang, Paula K. Greer, Huishan Zhu, Changzheng Du, Lee H. Chen, Chin-Pu Jason Chen, Casey J. Moure, Bill H. Diplas, Cheng Xu, Zhaohui Wang
Supplementary Fig. 1. Confirmation of SF7761 derived PPM1D-/- clones by Sanger sequencing. Supplementary Fig. 2. Effect of DNA repair inhibitors on cell viability in SF7761 parental and PPM1D-/- clones. Supplementary Fig. 3. GSK2830371 treatment syne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09eac298f5735baf414fca4eed2478b6
https://doi.org/10.1158/1541-7786.22513743
https://doi.org/10.1158/1541-7786.22513743
Autor:
Hai Yan, Yiping He, Darell D. Bigner, Roger E. McLendon, Ivan Spasojevic, Ping Fan, Cheryl B. Bock, Yu Wang, Jie Feng, Paula K. Greer, Lee H. Chen, Landon J. Hansen, Huishan Zhu, Catherine Y. Wang, Matthew S. Waitkus, Austin B. Carpenter, Christopher J. Pirozzi
Materials and Methods used for gene expression profiling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299ba4e8b6e2b48f41f7819d7132394b
https://doi.org/10.1158/1541-7786.22517373
https://doi.org/10.1158/1541-7786.22517373