LAT1 and SNAT2 Protein Expression and Membrane Localization of LAT1 Are Not Acutely Altered by Dietary Amino Acids or Resistance Exercise Nor Positively Associated with Leucine or Phenylalanine Incorporation in Human Skeletal Muscle

Autor: Michael Mazzulla, Nathan Hodson, Matthew Lees, Paula J. Scaife, Kenneth Smith, Philip J. Atherton, Dinesh Kumbhare, Daniel R. Moore

Publikováno v: Nutrients, Vol 13, Iss 11, p 3906 (2021)

The influx of essential amino acids into skeletal muscle is primarily mediated by the large neutral amino acid transporter 1 (LAT1), which is dependent on the glutamine gradient generated by the sodium-dependent neutral amino acid transporter 2 (SNAT

Externí odkaz: https://doaj.org/article/ff70c40e1499446093c07c9ae33d0114

Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease

Autor: Reinhard Stöger, Paula J. Scaife, Freya Shephard, Lisa Chakrabarti

Publikováno v: npj Parkinson's Disease, Vol 3, Iss 1, Pp 1-3 (2017)

Abstract 5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-li

Externí odkaz: https://doaj.org/article/313bead6c40041298b4aafaba6c38a62

Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies

Autor: Fiona Broughton Pipkin, Amy Simpson, Louise V. Briggs, Carolyn J.P. Jones, David S. Gardner, Lesia O. Kurlak, Paula J. Scaife, Hiten D. Mistry

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7295, p 7295 (2021)
Volume 22
Issue 14
Scaife, P J, Simpson, A, Kurlak, L O, Briggs, L V, Gardner, D S, Pipkin, F B, Jones, C J P & Mistry, H D 2021, ' Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies ', International Journal of Molecular Sciences, vol. 22, no. 14, 7295 . https://doi.org/10.3390/ijms22147295

Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can resu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c9473ee6405a3243e91a8da6648825
http://europepmc.org/articles/PMC8303298

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Autor: Dilbar Najmutdinova, Firuza Nishanova, Tatyana Hegay, John P. Kemp, Anna Helgadottir, Lucilla Poston, Saedis Saevarsdottir, Ralph McGinnis, Lilja Stefansdottir, Yr Frisbaek, Hrefna Johannsdottir, Olafur A. Stefansson, Thorunn A. Olafsdottir, Markus Perola, Scott Shooter, Frank Geller, Mads Melbye, Reynir Tómas Geirsson, Lill Trogstad, Thorhildur Juliusdottir, Kari Stefansson, Jonas Bybjerg-Grauholm, Eleonora Staines-Urias, Nodira Zakhidova, Daniel F. Gudbjartsson, Vinicius Tragante, João Fadista, Galina Berezina, Damilya Salimbayeva, Zosia Miedzybrodska, Katja Kivinen, James J. Walker, Kari Klungsøyr, Anna F. Dominiczak, Maria Carolina Borges, Fiona Broughton Pipkin, Nigel Simpson, Quaker E. Harmon, Per Magnus, Ashley Moffett, Tamara Aripova, Gordon Prescott, Sigrun Hjartardottir, Noor Kalsheker, Karina Meden Sørensen, Nicholas Williams, Hannele Laivuori, David M. Hougaard, Gulnara Svyatova, Debbie A Lawlor, Stephanie M. Engel, Gudmar Thorleifsson, Wai K. Lee, Paula J. Scaife, Christopher S. Franklin, Bjarke Feenstra, Irina Colgiu, Ann-Charlotte Iversen, Abdumadjit Kasimov, Jon K. Sigurdsson, Liv Cecilie Vestrheim Thomsen, Unnur Thorsteinsdottir, Line Skotte, Linda Morgan, Juan P Casas, Michael L. Frigge, Vivien A. Dolby, Frank Dudbridge, Valgerdur Steinthorsdottir, Suzannah Bumpstead, Kirsi M Auro, Ingileif Jonsdottir, Tiina Jääskeläinen, Heather A. Boyd, Solveig Gretarsdottir

Publikováno v: Nature Communications
Steinthorsdottir, V, McGinnis, R, Williams, N O, Stefansdottir, L, Thorleifsson, G, Shooter, S, Fadista, J, Sigurdsson, J K, Auro, K M, Berezina, G, Borges, M C, Bumpstead, S, Bybjerg-Grauholm, J, Colgiu, I, Dolby, V A, Dudbridge, F, Engel, S M, Franklin, C S, Frigge, M L, Frisbaek, Y, Geirsson, R T, Geller, F, Gretarsdottir, S, Gudbjartsson, D F, Harmon, Q, Hougaard, D M, Hegay, T, Helgadottir, A, Hjartardottir, S, Jääskeläinen, T, Johannsdottir, H, Jonsdottir, I, Juliusdottir, T, Kalsheker, N, Kasimov, A, Kemp, J P, Kivinen, K, Klungsøyr, K, Lee, W K, Melbye, M, Miedzybrodska, Z, Moffett, A, Najmutdinova, D, Nishanova, F, Olafsdottir, T, Perola, M, Pipkin, F B, Skotte, L, Sørensen, K M, Kere, J, FINNPEC Consortium & GOPEC Consortium 2020, ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ', Nature Communications, vol. 11, no. 1, 5976 . https://doi.org/10.1038/s41467-020-19733-6
et al. 2020, ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ', Nature Communications, vol. 11, 5976 (2020) . https://doi.org/10.1038/s41467-020-19733-6
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
2020, ' Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women ', Nature Communications, vol. 11, no. 1, 5976 . https://doi.org/10.1038/s41467-020-19733-6

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the mater

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c6a59b93fb4d8ac17970c34bafb35f
https://hdl.handle.net/11250/2754126

Salt, aldosterone and extrarenal Na+ - sensitive responses in pregnancy

Autor: Paula J. Scaife, Markus G. Mohaupt

Publikováno v: Placenta

Outside of pregnancy excessive salt consumption is known to be harmful being linked to increased blood pressure and cardiovascular disease. However, pregnancy represents a major change to a woman's physiology resulting in an intimate adaptation to en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac6aa8aa5e2d292e6b362d84ae56f6b
https://doi.org/10.1016/j.placenta.2017.01.100