The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling.

Autor: Jason A Scott, Paula J Klutho, Ramzi El Accaoui, Emily Nguyen, Ashlee N Venema, Litao Xie, Shuxia Jiang, Megan Dibbern, Sabrina Scroggins, Anand M Prasad, Elisabeth D Luczak, Melissa K Davis, Weiwei Li, Xiaoqun Guan, Johannes Backs, Annette J Schlueter, Robert M Weiss, Francis J Miller, Mark E Anderson, Isabella M Grumbach

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71550 (2013)

OBJECTIVE:Sustained hemodynamic stress mediated by high blood flow promotes arteriogenesis, the outward remodeling of existing arteries. Here, we examined whether Ca²⁺/calmodulin-dependent kinase II (CaMKII) regulates arteriogenesis. METHODS AND R

Externí odkaz: https://doaj.org/article/a6212747293a4b058e5501de611d149f

Cardiac Myocyte‐Specific Overexpression of FASTKD1 Prevents Ventricular Rupture After Myocardial Infarction

Autor: Kurt D. Marshall, Paula J. Klutho, Lihui Song, Rajika Roy, Maike Krenz, Christopher P. Baines

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023)

Background The mitochondrial mRNA‐binding protein FASTKD1 (Fas‐activated serine/threonine [FAST] kinase domain–containing protein 1) protects myocytes from oxidative stress in vitro. However, the role of FASTKD1 in the myocardium in vivo is unk

Externí odkaz: https://doaj.org/article/738ae8aba2dd43b596d5261e673d3202

Genetic manipulation of SPG7 or NipSnap2 does not affect mitochondrial permeability transition

Autor: Ryan J. Dashek, Lihui Song, Paula J. Klutho, Christopher P. Baines

Publikováno v: Cell Death Discovery, Vol 6, Iss 1, Pp 1-3 (2020)
Cell Death Discovery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf137473f37cd4229810ad32037380b
https://doi.org/10.1038/s41420-020-0239-6

Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure

Autor: R. John Solaro, Chad M. Warren, Chen Gao, Timothy L. Domeier, Stephanie C. Ferreira-Nichols, Jan R. Ivey, Maike Krenz, Linda Alex, Jaume Padilla, John L. Jones, Yibin Wang, Thomas J. Jurrissen, Christoph Rau, R. Scott Rector, Christopher P. Baines, Jenna C. Edwards, Paula J. Klutho, T. Dylan Olver, David A. Ford, Kerry S. McDonald, Craig A. Emter, Adam B. Veteto, Pamela K. Thorne

Publikováno v: JACC. Basic to translational science, vol 4, iss 3
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 404-421 (2019)

Visual Abstract
Highlights • The combination of a Western-diet and aortic banding results in a cardio-metabolic heart failure phenotype in Ossabaw swine. • Ossabaw swine with cardio-metabolic heart failure display cardiac dysfunction at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddbaeb8b6b97277796ad4183f62766a6
https://escholarship.org/uc/item/2pt6t1r5

Abstract 524: Deletion of Methionine Sulfoxide Reductase A in Mice Increases Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia

Autor: Paula J Klutho, Jason Scott, Litao Xie, Isabella M Grumbach

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 34

Introduction: Neointima formation is the leading cause of restenosis after balloon angioplasty and surgical endarterectomy. ROS production promotes neointimal hyperplasia and causes methionine oxidation. Recent data suggest that oxidation of methioni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d565432380b075dc717d3d0b1bc06c5
https://doi.org/10.1161/atvb.34.suppl_1.524