Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Paula J Bucko"'
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Akademický článek
Subcellular drug targeting illuminates local kinase action
Autor: Paula J Bucko, Chloe K Lombard, Lindsay Rathbun, Irvin Garcia, Akansha Bhat, Linda Wordeman, F Donelson Smith, Dustin J Maly, Heidi Hehnly, John D Scott
Publikováno v: eLife, Vol 8 (2019)
Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase anchoring proteins (AKAPs) restrict the range of action of protein kinases within intracellular compartments. W
Externí odkaz: https://doaj.org/article/0ba69f49111048bc8e8df7812b20c536
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2
Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles
Autor: Linda Wordeman, John D. Scott, Akansha Bhat, Paula J. Bucko, Irvin Garcia, Ridhima Manocha
Publikováno v: J Biol Chem
Mitogenic signals that regulate cell division often proceed through multi-enzyme assemblies within defined intracellular compartments. The anchoring protein Gravin restricts the action of mitotic kinases and cell-cycle effectors to defined mitotic st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b59538f5944cefb44548744784ec339
https://doi.org/10.1074/jbc.ra120.014791
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3
Drugs That Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option
Autor: John D. Scott, Paula J. Bucko
Publikováno v: Annual review of pharmacology and toxicology. 61
Cells respond to environmental cues by mobilizing signal transduction cascades that engage protein kinases and phosphoprotein phosphatases. Correct organization of these enzymes in space and time enables the efficient and precise transmission of chem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4c5786460a66e8af650a7974f4b2d4
https://pubmed.ncbi.nlm.nih.gov/32628872
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6
AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption
Autor: Janani Gopalan, John D. Scott, Jennifer L. Whiting, Ole Morten Seternes, Leah Ogier, Lorene K. Langeberg, Katherine A. Forbush, Paula J. Bucko
Publikováno v: Proceedings of the National Academy of Sciences. 113
Filtration through the kidney eliminates toxins, manages electrolyte balance, and controls water homeostasis. Reabsorption of water from the luminal fluid of the nephron occurs through aquaporin-2 (AQP2) water pores in principal cells that line the k
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a4201b20d41122035f5b115525b8b6
https://doi.org/10.1073/pnas.1607745113
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7
A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells
Autor: Irwin H. Gelman, David A. Canton, Lorene K. Langeberg, Leah Ogier, L. Fernando Santana, Paula J. Bucko, John D. Scott, Heidi Hehnly, Linda Wordeman
Publikováno v: eLife
eLife, Vol 4 (2015)
eLife, vol 4, iss September
Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb89d5ede21e88d3fa2837b621eef93
https://doi.org/10.7554/elife.09384
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