Zobrazeno 1 - 10
of 22 230
pro vyhledávání: '"Paula J"'
Publikováno v:
JIMD Reports, Vol 65, Iss 6, Pp 433-441 (2024)
Abstract Glutaric aciduria type 1 (GA1) is an inherited neurometabolic disorder, in which deficiency of glutaryl‐CoA dehydrogenase leads to accumulation of glutaric acid (GA) and 3‐hydroxyglutaric acid (3‐HG). Some low excretors may exhibit onl
Externí odkaz:
https://doaj.org/article/b014b0ec9efc4fb6b585fa913d9cfcbc
Autor:
Sang‐Won Han, Young Ho Park, Paula J Bice, David A. Bennett, SangYun Kim, Andrew J. Saykin, Kwangsik Nho
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 10, Pp 2799-2804 (2024)
Abstract A synaptic protein, Neuronal Pentraxin 2 (NPTX2), has emerged as a pivotal biomarker for Alzheimer's dementia (AD). We identified candidate miRNAs targeting NPTX2 and performed association and mediation analyses using multi‐omics data (N =
Externí odkaz:
https://doaj.org/article/0de7246f31f447c58a400279cbcd01b2
Autor:
Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Paula J. Bice, Jared R. Brosch, Rachael Deardorff, Kelley Faber, Martin R. Farlow, Tatiana Foroud, Sujuan Gao, Thea Rosewood, Jun Pyo Kim, Kelly Nudelman, Meichen Yu, Paul Aisen, Reisa Sperling, Basavaraj Hooli, Sergey Shcherbinin, Diana Svaldi, Clifford R. Jack, William J. Jagust, Susan Landau, Aparna Vasanthakumar, Jeffrey F. Waring, Vincent Doré, Simon M. Laws, Colin L. Masters, Tenielle Porter, Christopher C. Rowe, Victor L. Villemagne, Logan Dumitrescu, Timothy J. Hohman, Julia B. Libby, Elizabeth Mormino, Rachel F. Buckley, Keith Johnson, Hyun-Sik Yang, Ronald C. Petersen, Vijay K. Ramanan, Nilüfer Ertekin-Taner, Prashanthi Vemuri, Ann D. Cohen, Kang-Hsien Fan, M. Ilyas Kamboh, Oscar L. Lopez, David A. Bennett, Muhammad Ali, Tammie Benzinger, Carlos Cruchaga, Diana Hobbs, Philip L. De Jager, Masashi Fujita, Vaishnavi Jadhav, Bruce T. Lamb, Andy P. Tsai, Isabel Castanho, Jonathan Mill, Michael W. Weiner, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI), the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN), the Australian Imaging, Biomarker & Lifestyle Study (AIBL), Andrew J. Saykin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Determining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron
Externí odkaz:
https://doaj.org/article/534dba93d5bf4620975ce9a0f564baf7
Publikováno v:
BMC Health Services Research, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Colorectal cancer (CRC) is globally the third most prevalent cancer and a leading cause of cancer-related deaths. In Alberta, Canada, a significant portion of CRC diagnoses occur following emergency department (ED) presentations.
Externí odkaz:
https://doaj.org/article/64f4ee95db574e5088f13d91446cc796
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Purpose In light of the mounting prevalence of stress in contemporary society and the growing interest in stress reduction methods, this review investigates the potential of taiji as a viable strategy for alleviating stress. Methods MEDLINE,
Externí odkaz:
https://doaj.org/article/64322a121d864be690f6bfee78f08161
Autor:
Mindi Ruan, Na Zhang, Xiangxu Yu, Wenqi Li, Chuanbo Hu, Paula J. Webster, Lynn K. Paul, Shuo Wang, Xin Li
Publikováno v:
Frontiers in Neuroinformatics, Vol 18 (2024)
IntroductionEarly and accurate diagnosis of autism spectrum disorder (ASD) is crucial for effective intervention, yet it remains a significant challenge due to its complexity and variability. Micro-expressions are rapid, involuntary facial movements
Externí odkaz:
https://doaj.org/article/04ab6d6f5a894634afd6d44672455e9f
Autor:
Paula J. M. van Kleeff, Marieke Mastop, Pulu Sun, Sarmina Dangol, Eva van Doore, Henk L. Dekker, Gertjan Kramer, Soohyun Lee, Choong-Min Ryu, Martin de Vos, Robert C. Schuurink
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 37, Iss 4, Pp 380-395 (2024)
Bemisia tabaci (whitefly) is a polyphagous agroeconomic pest species complex. Two members of this species complex, Mediterranean (MED) and Middle-East-Asia Minor 1 (MEAM1), have a worldwide distribution and have been shown to manipulate plant defense
Externí odkaz:
https://doaj.org/article/4309be6a0d824c639f8ff170cec7511a
Autor:
Brad. A. Davidson, Adam X. Miranda, Sarah C. Reed, Riley E. Bergman, Justin D. J. Kemp, Anvith P. Reddy, Morgan V. Pantone, Ethan K. Fox, R. Dixon Dorand, Paula J. Hurley, Sarah Croessmann, Ben Ho Park
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abtract Clinical circulating cell-free DNA (cfDNA) testing is now routine, however test accuracy remains limited. By understanding the life-cycle of cfDNA, we might identify opportunities to increase test performance. Here, we profile cfDNA release a
Externí odkaz:
https://doaj.org/article/cd38cce8a1ef451b8131639ce536497b
Autor:
Anna Pujadas Botey, Tara R. Bond, Eliya Farah, Chantelle Carbonell, Stacey Dyck, Angela Estey, Douglas A. Stewart, Darren R. Brenner, Paula J. Robson
Publikováno v:
Current Oncology, Vol 31, Iss 3, Pp 1470-1476 (2024)
This commentary provides a detailed overview of the extensive stakeholder engagement efforts critical to the development of the Future of Cancer Impact (FOCI) in Alberta report. The overarching aim of the FOCI report was to support informed and strat
Externí odkaz:
https://doaj.org/article/e91e60966a664a25b8b858bfdad194da
Autor:
Franklin R. Toapanta, Jingping Hu, Kari Ann Shirey, Paula J. Bernal, Myron M. Levine, Thomas C. Darton, Claire S. Waddington, Andrew J. Pollard, Marcelo B. Sztein
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
An oral Controlled Human Infection Model (CHIM) with wild-type S. Typhi was re-established allowing us to explore the development of immunity. In this model, ~55% of volunteers who received the challenge reached typhoid diagnosis criteria (TD), while
Externí odkaz:
https://doaj.org/article/7f2e05bb0a404438a4c9919701980c1f