Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium

Autor: Paula I. Seoane, James A. Beswick, Andrew G. Leach, Tessa Swanton, Lucy V. Morris, Kevin Couper, Martin Lowe, Sally Freeman, David Brough

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)

Abstract The NLRP3 inflammasome is a component of the inflammatory response to infection and injury, orchestrating the maturation and release of the pro-inflammatory cytokines interleukin-1β (IL-1β), IL-18, and triggering pyroptotic cell death. App

Externí odkaz: https://doaj.org/article/38f74ab91955427e865abe6c6a9ba28b

Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome

Autor: Bali Lee, Christopher Hoyle, Rose Wellens, Jack P. Green, Fatima Martin-Sanchez, Daniel M. Williams, Billie J. Matchett, Paula I. Seoane, Hayley Bennett, Antony Adamson, Gloria Lopez-Castejon, Martin Lowe, David Brough

Publikováno v: Lee, B, Hoyle, C, Wellens, R, Green, J P, Martin-Sanchez, F, Williams, D M, Matchett, B J, Seoane, P I, Bennett, H, Adamson, A, Lopez-Castejon, G, Lowe, M & Brough, D 2023, ' Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome ', Science Signaling, vol. 16, no. 773 . https://doi.org/10.1126/scisignal.abm7134

Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that NLRP3 senses disrupted endosome trafficking to trigger inflammasome forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af561ca983c5ec69eee329df91be13e
https://doi.org/10.1126/scisignal.abm7134

Viral infection triggers interferon-induced expulsion of live Cryptococcus neoformans by macrophages

Autor: Leanne M. Taylor-Smith, Paula I. Seoane, Mahdad Noursadeghi, Lucy C K Bell, Dalan Bailey, David Stirling, Robin C. May

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 2, p e1008240 (2020)

Cryptococcus neoformans is an opportunistic human pathogen, which causes serious disease in immunocompromised hosts. Infection with this pathogen is particularly relevant in HIV+ patients, where it leads to around 200,000 deaths per annum. A key feat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c185d28b133d06fdbb4aab2c49b45952
http://europepmc.org/articles/PMC7046190

Inefficient and abortive classical complement pathway activation by the calcium inositol hexakisphosphate component of the Echinococcus granulosus laminated layer

Autor: Sebastián Miles, Alvaro Díaz, Paula I. Seoane, Gustavo Mourglia-Ettlin, Mara Mariconti, Anabella A. Barrios, Leticia Grezzi

Publikováno v: Immunobiology. 224(5)

Persistent extracellular tissue-dwelling pathogens face the challenge of antibody-dependent activation of the classical complement pathway (CCP). A prime example of this situation is the larva of the cestode Echinococcus granulosus sensu lato, causin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9c82dc238c86e0dbbdea4c3a23ac8d
https://pubmed.ncbi.nlm.nih.gov/31178241

The M2 triangle:gp130 binding cytokines drive macrophages to promote tumor growth

Autor: Paula I. Seoane, Dominik Rückerl

Publikováno v: Rückerl, D & Seoane, P I 2018, ' The M2 triangle : gp130 binding cytokines drive macrophages to promote tumor growth ', Immunology and cell biology . https://doi.org/10.1111/imcb.12016

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8c0c43b9a60a7111c05a496ee03ae4
https://www.research.manchester.ac.uk/portal/en/publications/the-m2-triangle(8b718975-5ba7-496f-911b-7d3a64c4e102).html