Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Paula Grasberger"'
Autor:
Louise Cadzow, Erica Tobin, Pamela Sullivan, Sol Shenker, Sumeet Nayak, Janid Ali, Hugh Gannon, Anne Dodson, Paula Grasberger, Alyssa Carlson, Michael McGuire, Jehrod Brenneman, Hanlan Liu, Andrew Olaharski, Kerstin Sinkevicius, Jeff Hixon, Elsa Krall, Mike Schlabach, Matt Goulet, Jeremy Wilt, Patricia Harris, Frank Stegmeier, Andrew Wylie
Publikováno v:
Cancer Research. 82:ND01-ND01
Tumors with BRCA1/2 mutations and other homologous repair deficiencies (HRD) are vulnerable to agents that target the remaining DNA repair pathways, including platinum-containing chemotherapy agents and molecules targeting poly (ADP-ribose) polymeras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9539d68445d92dc285a006c95dfa078
https://doi.org/10.1158/1538-7445.am2022-nd01
https://doi.org/10.1158/1538-7445.am2022-nd01
Autor:
Royale Nichols, Jillian J Spinney, Michael Bieler, Katharine E. Black, Yufei Lin, Lida P. Hariri, Clemens K. Probst, Paul Nicklin, Benjamin D. Medoff, Lorena Pantano, Paula Grasberger, Peter Seither, David Wyatt, Daniela M. Santos, Gina Pronzati, Andrew M. Tager
Publikováno v:
Am J Respir Cell Mol Biol
Idiopathic pulmonary fibrosis is a lung disease with limited therapeutic options that is characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. YAP (Yes-associated protein) is a transcriptional coactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69e7ff705685e150c6c5d62f81c340b
https://europepmc.org/articles/PMC7110981/
https://europepmc.org/articles/PMC7110981/
Autor:
Katharine E. Black, Norihiko Sakai, Jillian J Spinney, Linlin Zhang, James K. Liao, Andrew M. Tager, David Lagares, Alicia Franklin, Benjamin D. Medoff, Rachel S. Knipe, Paula Grasberger, Patricia L. Brazee, Barry S. Shea, Clemens K. Probst
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:471-481
Pulmonary fibrosis is thought to result from dysregulated wound repair after repetitive lung injury. Many cellular responses to injury involve rearrangements of the actin cytoskeleton mediated by the two isoforms of the Rho-associated coiled-coil-for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce4d303cf64cbf0d2d2302e8cb238cfd
https://doi.org/10.1165/rcmb.2017-0075oc
https://doi.org/10.1165/rcmb.2017-0075oc
Autor:
Rajiv Gandhi, Andrew M. Tager, Moisés Selman, Barry S. Shea, Neil Ahluwalia, Alicia Franklin, Daniela M. Santos, Mohit Kapoor, Rachel S. Knipe, Caroline Tremblay, Katharine E. Black, Jean-Pierre Pelletier, Meryem Blati, Annie Pardo, Alba Santos, Clemens K. Probst, Hassan Fahmi, David Lagares, Jiangping Wu, Sydney B. Montesi, Murray Baron, Parisa Ghassemi-Kakroodi, Paula Grasberger, Brian Wu, Johanne Martel-Pelletier
Publikováno v:
Nature Medicine. 23:1405-1415
Maladaptive wound healing responses to chronic tissue injury result in organ fibrosis. Fibrosis, which entails excessive extracellular matrix (ECM) deposition and tissue remodeling by activated myofibroblasts, leads to loss of proper tissue architect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01285500d33f5ebe19f9b770dc23c96f
https://doi.org/10.1038/nm.4419
https://doi.org/10.1038/nm.4419
Autor:
Jillian J Spinney, G. Pronzati, Katharine E. Black, Benjamin D. Medoff, Clemens K. Probst, Lorena Pantano, Andrew M. Tager, Daniela M. Santos, David Wyatt, Y. Lin, R. Nichols, Paula Grasberger
Publikováno v:
D17. TOWARDS THE NEXT IPF THERAPIES.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0e3e854e2081b35965bd1be5d853986
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5878
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5878
Autor:
Paula Grasberger, Moisés Selman, David Lagares, Brian Mugo, Annie Pardo, Carol Feghali-Bostwick, Neil Ahluwalia, Andrew M. Tager
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:831-842
Pathologic accumulation of fibroblasts in pulmonary fibrosis appears to depend on their invasion through basement membranes and extracellular matrices. Fibroblasts from the fibrotic lungs of patients with idiopathic pulmonary fibrosis (IPF) have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3528b4080d6f945c6b4010c475ce45bc
https://doi.org/10.1165/rcmb.2015-0040oc
https://doi.org/10.1165/rcmb.2015-0040oc
Autor:
Jeremy Ryan, David Lagares, Joan Montero, Murray Baron, Anthony Letai, Tobias Kuehl, Patrick Bhola, Andrew M. Tager, Mohit Kapoor, Norihiko Sakai, Alba Santos, Paula Grasberger, Fei Liu, Daniel J. Tschumperlin, Clemens K. Probst, Xaralabos Varelas, Rod A. Rahimi
Publikováno v:
Science Translational Medicine. 9
Persistent myofibroblast activation distinguishes pathological fibrosis from physiological wound healing, suggesting that therapies selectively inducing myofibroblast apoptosis could prevent progression and potentially reverse established fibrosis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb3587afefa929b0e6fa0eea00f5cf7
https://doi.org/10.1126/scitranslmed.aal3765
https://doi.org/10.1126/scitranslmed.aal3765
Corrigendum: ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Autor:
Jean-Pierre Pelletier, Parisa Ghassemi-Kakroodi, Alba Santos, Murray Baron, Mohit Kapoor, Caroline Tremblay, Rachel S. Knipe, Moisés Selman, Katharine E. Black, Hassan Fahmi, Brian Wu, Sydney B. Montesi, Neil Ahluwalia, Andrew M. Tager, Johanne Martel-Pelletier, David Lagares, Alicia Franklin, Meryem Blati, Paula Grasberger, Annie Pardo, Daniela M. Santos, Jiangping Wu, Rajiv Gandhi, Barry S. Shea, Clemens K. Probst
Publikováno v:
Nature medicine
Maladaptive wound healing responses to chronic tissue injury result in organ fibrosis. Fibrosis, which entails excessive extracellular matrix (ECM) deposition and tissue remodelling by activated myofibroblasts, leads to loss of proper tissue architec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145a1797e7cf452a5c3893a8df9a6bbb
https://pubmed.ncbi.nlm.nih.gov/29058717
https://pubmed.ncbi.nlm.nih.gov/29058717
Publikováno v:
QJM: An International Journal of Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::666136a7531b7ab06cc66cf204c6f149
https://doi.org/10.1093/qjmed/hcw127.001
https://doi.org/10.1093/qjmed/hcw127.001
Autor:
Paula Grasberger, Andrew M. Tager, Barry S. Shea, Alicia Franklin, Rachel S. Knipe, Neil Ahluwalia, James K. Liao, David Lagares, Clemens K. Probst
Publikováno v:
QJM: An International Journal of Medicine.
Background and Rationale: The actin cytoskeleton directs many pro-fibrotic cellular responses in pulmonary fibrosis, including epithelial cell apoptosis, endothelial cell barrier disruption and fibroblast migration and differentiation. The Rho kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2299521fc26691a44941e38a3854bb8
https://doi.org/10.1093/qjmed/hcw127.035
https://doi.org/10.1093/qjmed/hcw127.035