Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Paula G. Fraenkel"'
Autor:
Hélène Bonnevaux, Stephane Guerif, Jana Albrecht, Erwan Jouannot, Thibaud De Gallier, Christian Beil, Christian Lange, Wulf Dirk Leuschner, Marion Schneider, Cendrine Lemoine, Anne Caron, Céline Amara, Cédric Barrière, Justine Siavellis, Valérie Bardet, Ernesto Luna, Pankaj Agrawal, Donald R. Drake, Ercole Rao, Peter Wonerow, Chantal Carrez, Véronique Blanc, Karl Hsu, Dmitri Wiederschain, Paula G. Fraenkel, Angéla Virone-Oddos
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Novel therapies are needed for effective treatment of AML. In the relapsed setting, prognosis is very poor despite salvage treatment with chemotherapy. Evidence suggests that leukemic stem cells (LSCs) cause relapse. The cell surface receptor CD123 i
Externí odkaz:
https://doaj.org/article/1e989dd4f1bc4fabbee1419fc76e4439
Autor:
Tiago Koppe, Bonnie Patchen, Aaron Cheng, Manoj Bhasin, Chris Vulpe, Robert E. Schwartz, Jose Maria Moreno‐Navarrete, Jose Manuel Fernandez‐Real, Pavlos Pissios, Paula G. Fraenkel
Publikováno v:
Hepatology Communications, Vol 1, Iss 8, Pp 803-815 (2017)
Iron overload causes the generation of reactive oxygen species that can lead to lasting damage to the liver and other organs. The goal of this study was to identify genes that modify the toxicity of iron overload. We studied the effect of iron overlo
Externí odkaz:
https://doaj.org/article/1984d87b3c284ddf9d44de9cc56f0ec5
Autor:
Vivek Subbiah, Dmitriy Zamarin, Omid Hamid, Igor Feldman, Thomas Marron, Yuling Wu, Inderjit Mehmi, Michael Abadier, Analia Azaro, Anthony El-Khoueiry, Eduardo Castañón Álvarez, Jacky Chow, Praveen Aanur, Khanh Do, Vasudha Sehgal, Sandip P Patel, Benedito Carneiro, Linh Van, Nicholas Durham, Xiaoru Chen, Paula G Fraenkel, Arjun Oberoi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/c2b5cd1235c14787ac32086337332951
Autor:
Eduardo Castañón, Dmitriy Zamarin, Benedito A. Carneiro, Thomas Marron, Sandip Pravin Patel, Vivek Subbiah, Inderjit Mehmi, Honey Kumar Oberoi, Anthony El-Khoueiry, Benjamin Ridgway, Nairouz Elgeioushi, Nicholas M. Durham, Emily Jennings, Michael Abadier, Paula G. Fraenkel, Analia Azaro, Omid Hamid
Publikováno v:
Cancer Research. 83:CT004-CT004
Background: MEDI1191 is an IT-administered lipid nanoparticle-formulated mRNA encoding IL-12. This phase 1, open-label study (NCT03946800) showed that MEDI1191 in sequential (seq) or concurrent (conc) combination with IV D (anti-PD-L1) was safe and h
Autor:
Abderrahmane Tagmount, Jie Zhou, Chris D. Vulpe, Alex Loguinov, Nader El Ahmadie, Paula G. Fraenkel, Amin Sobh, Supak Jenkitkasemwong, Rola S Zeidan, Mitchell D. Knutson
Publikováno v:
American Journal of Hematology. 95:1085-1098
Transferrin-bound iron (TBI), the physiological circulating iron form, is acquired by cells through the transferrin receptor (TfR1) by endocytosis. In erythroid cells, most of the acquired iron is incorporated into heme in the mitochondria. Cellular
Autor:
Paula G. Fraenkel, C Balk, S V Klymenko, Larysa Poluben, Oleksandr Shumeiko, L V Neumerzhytska
Publikováno v:
Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology. 25:362-373
to determine the frequency of major somatic mutations in the JAK2, MPL and CALR genes in the genomeof patients with Ph-negative myeloproliferative neoplasms that occur in individuals who have been exposed to ionizing radiation as a result of the Chor
Autor:
Jacalyn Rosenblatt, Ozlem Yildirim, David Avigan, Paula G. Fraenkel, Joshua Hauser, Maryam Rahimian, Lina Bisharat, Myrna Nahas, Dina Stroopinsky, Anita G. Koshy, Stephane Guerif, Giulia Cheloni, Hélène Bonnevaux, Daniela Torres, Donald Kufe, Poorva Bindal, Jessica Liegel
Publikováno v:
Blood. 138:904-904
Introduction: Immunotherapy for AML holds promise in overcoming chemotherapy resistance and in preserving immunologic memory necessary for durable remissions.A bispecific T-cell engaging antibody targeting CD3 and CD123 (CD123-CODV-TCE) has been show
Autor:
Paula G. Fraenkel
Publikováno v:
Medical Clinics of North America. 101:285-296
Impaired iron homeostasis and the suppressive effects of proinflammatory cytokines on erythropoiesis, together with alterations of the erythrocyte membrane that impair its survival, cause anemia of inflammation. Recent epidemiologic studies have conn
Autor:
Paula G. Fraenkel, B. T. Klimuk, Oleksandr Shumeiko, Larysa Poluben, Steven P. Balk, Y Hsu, Ch R Bryke, L. A. Rybchenko, S V Klymenko, L Neumerzhitska
Publikováno v:
Experimental Oncology. 41
AIM To examine frequencies and spectrum of genomic alterations in Ukrainian patients diagnosed with primary myelofibrosis (PMF). MATERIALS AND METHODS We enrolled 30 Ukrainian patients diagnosed with PMF who were previously tested for usual mutations
Autor:
Steven P. Balk, Larysa Poluben, Roni Rasnic, Miriam Adam, Michal Linial, Paula G. Fraenkel, Oleksandr Shumeiko, German Pihan, Ernest Fraenkel, Xin Yuan, Christine R. Bryke, Donna Neuberg, Olga Voznesensky, Maneka Puligandla, S V Klymenko, Yahsuan Hsu
Publikováno v:
PMC
Myeloproliferative neoplasms (MPNs) driver mutations are usually found in JAK2, MPL, and CALR genes; however, 10%-15% of cases are triple negative (TN). A previous study showed lower rate of JAK2 V617F in primary myelofibrosis patients exposed to low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0bdc3c060945842714158fd7c4e7b5
https://hdl.handle.net/1721.1/126343
https://hdl.handle.net/1721.1/126343