4-Methylumbelliferone enhances the effects of chemotherapy on both temozolomide-sensitive and resistant glioblastoma cells

Autor: Matías A. Pibuel, Daniela Poodts, Sofía A. Sias, Agustín Byrne, Silvia E. Hajos, Paula G. Franco, Silvina L. Lompardía

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)

Abstract Glioblastoma (GBM) is the most frequent malignant primary tumor of the CNS in adults, with a median survival of 14.6 months after diagnosis. The effectiveness of GBM therapies remains poor, highlighting the need for new therapeutic alternati

Externí odkaz: https://doaj.org/article/723febe56c0c4d848adbdc56e0b921f5

4-Methylumbelliferone as a potent and selective antitumor drug on a glioblastoma model

Autor: Mariángeles Díaz, Lucas Silvestroff, Matías Pibuel, Daniela Poodts, Paula G. Franco, Silvina Lompardía, Silvia E. Hajos, Yamila Azul Molinari

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Glioblastoma (GBM), the most frequent primary tumor of the central nervous system, has a median survival of 14.6 months. 4-Methylumbelliferone (4MU) is a coumarin derivative widely used as a hyaluronan synthesis inhibitor with proven antitumor activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bb493945f4922f114c691a325b6d93
https://doi.org/10.1093/glycob/cwaa046

Optimizing culture medium composition to improve oligodendrocyte progenitor cell yields in vitro from subventricularzone-derived neural progenitor cell neurospheres

Autor: Paula G. Franco, Lucas Silvestroff, Juana M. Pasquini

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0121774 (2015)

Neural Stem and Progenitor Cells (NSC/NPC) are gathering tangible recognition for their uses in cell therapy and cell replacement therapies for human disease, as well as a model system to continue research on overall neural developmental processes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197cff19ba6d269edf029ed11395e4d3

Notch activates sonic hedgehog and both are involved in the specification of dorsal midline cell-fates inXenopus

Autor: Alejandra R. Paganelli, Andrés E. Carrasco, Paula G. Franco, Oscar H. Ocaña, Silvia L. López, María Victoria Rosato Siri

Publikováno v: Development. 130:2225-2238

We analysed the role of Notch signalling during the specification of the dorsal midline in Xenopus embryos. By activating or blocking the pathway we found that Notch expands the floor plate domain of sonic hedgehog and pintallavis and represses the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c450397997c129261ed0fd77240c5e0
https://doi.org/10.1242/dev.00443

The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis

Autor: Andrés E. Carrasco, Ana M. Adamo, Martin M. Riccomagno, Eduardo M. Castaño, Mikio Shoji, Oscar H. Ocaña, Laura Morelli, Alejandra R. Paganelli, Paula G. Franco, Silvia L. López, José L. Affranchino, Etsuro Matsubara, María I. Prat

Publikováno v: Mechanisms of Development. 107:119-131

We analyzed the influence of presenilins on the genetic cascades that control neuronal differentiation in Xenopus embryos. Resembling sonic hedgehog (shh) overexpression, presenilin mRNA injection reduced the number of N-tubulin 1 primary neurons and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602d3f52d66eb6ce60cf3bf44b309efa
https://doi.org/10.1016/s0925-4773(01)00458-0