Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Paula Freire-Pritchett"'
Autor:
Szymon Juszkiewicz, Greg Slodkowicz, Zhewang Lin, Paula Freire-Pritchett, Sew-Yeu Peak-Chew, Ramanujan S Hegde
Publikováno v:
eLife, Vol 9 (2020)
Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate protein and mRNA quality control pathways. Here we found using quantitativ
Externí odkaz:
https://doaj.org/article/25320fe37bca42ca940a58711529e988
Autor:
Hashem Koohy, Daniel J. Bolland, Louise S. Matheson, Stefan Schoenfelder, Claudia Stellato, Andrew Dimond, Csilla Várnai, Peter Chovanec, Tamara Chessa, Jeremy Denizot, Raquel Manzano Garcia, Steven W. Wingett, Paula Freire-Pritchett, Takashi Nagano, Phillip Hawkins, Len Stephens, Sarah Elderkin, Mikhail Spivakov, Peter Fraser, Anne E. Corcoran, Patrick D. Varga-Weisz
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-24 (2018)
Abstract Background Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell development, we profiled gene expression and chromatin f
Externí odkaz:
https://doaj.org/article/6176506a0b014dd1a2e2a5beb2a2e029
Autor:
Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser, Bernard D. Keavney
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions
Externí odkaz:
https://doaj.org/article/83ebcba231fa46148d8363dbe91cb2fe
Autor:
Clara Lopes Novo, Biola-Maria Javierre, Jonathan Cairns, Anne Segonds-Pichon, Steven W. Wingett, Paula Freire-Pritchett, Mayra Furlan-Magaril, Stefan Schoenfelder, Peter Fraser, Peter J. Rugg-Gunn
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2615-2627 (2018)
Summary: Transcriptional enhancers, including super-enhancers (SEs), form physical interactions with promoters to regulate cell-type-specific gene expression. SEs are characterized by high transcription factor occupancy and large domains of active ch
Externí odkaz:
https://doaj.org/article/a9fe24befd3e4a119da1557f07e1eacc
Autor:
Paula Freire-Pritchett, Stefan Schoenfelder, Csilla Várnai, Steven W Wingett, Jonathan Cairns, Amanda J Collier, Raquel García-Vílchez, Mayra Furlan-Magaril, Cameron S Osborne, Peter Fraser, Peter J Rugg-Gunn, Mikhail Spivakov
Publikováno v:
eLife, Vol 6 (2017)
Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of cis-re
Externí odkaz:
https://doaj.org/article/6b57a130ecbc478aaa570feb12bd03e6
Autor:
Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser, Bernard D. Keavney
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the original version of the Article, the gene symbol for tissue factor pathway inhibitor was inadvertently given as ‘TFP1’ instead of ‘TFPI’. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/35aca2c785854661b366136c84b028b5
Autor:
William R. Orchard, Valeriya Malysheva, Jonathan Cairns, Steven Wingett, Paula Freire-Pritchett, Mikhail Spivakov, Helen Ray-Jones, Chris Eijsbouts, Chris Wallace, Monica Della Rosa
Publikováno v:
Nat Protoc
Capture Hi-C is widely used to obtain high-resolution profiles of chromosomal interactions involving, at least on one end, regions of interest such as gene promoters. Signal detection in Capture Hi-C data is challenging and cannot be adequately accom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5b7d6c8db4063913df826129dd424f
Autor:
Ralitsa R. Madsen, Benjamin G. Stokell, Paula Freire-Pritchett, Jennifer L. Harman, Amanda Dalby, Anna K. Uryga, Martin R. Bennett, Alison Finigan, Elena Loche, Helle F. Jørgensen, Lina Dobnikar, Matthew D. Worssam, Annabel L. Taylor, Joel Chappell, Kirsty Foote
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 39:2289-2302
Objective: Vascular inflammation underlies cardiovascular disease. Vascular smooth muscle cells (VSMCs) upregulate selective genes, including MMPs (matrix metalloproteinases) and proinflammatory cytokines upon local inflammation, which directly contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3e2750a2fb6b45f673a62e63e55c63
https://doi.org/10.1161/atvbaha.119.312765
https://doi.org/10.1161/atvbaha.119.312765
Autor:
Stephanie Wunderlich, Iva Kelava, Gregory A. Wray, Silvia Benito-Kwiecinski, Madeline A. Lancaster, Stefano L. Giandomenico, Kate McDole, Magdalena Sutcliffe, Erlend S. Riis, Paula Freire-Pritchett, Ulrich Martin
Publikováno v:
Cell
Summary The human brain has undergone rapid expansion since humans diverged from other great apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use cerebral organoids derived from human, gorilla, and chimpanzee cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad8a8e7dfb9bda1c0fb81d7ab211463