Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Paula Francom"'
Autor:
Craig J. Morton, Barbara Frey, George Kukolj, Alistair George Draffan, Van T. T. Nguyen, Angela Luttick, Tyrone Pieter Jeynes, Ginette McKercher, Bruno Simoneau, Richard Hufton, Kate Porter, Danielle Tilmanis, Bo Lin, Simon P. Tucker, Jesse D. Thomas, Melinda J. Pryor, Jianmin Duan, Lilly Michael John, Paula Francom, Edward M. Tyndall, Silas Bond, Lisette Lagacé, Carlie T. Gannon, Ma’an Amad, Veronika Wirth, Rosliana Halim, Richard Bethell, Saba Jahangiri, Brett Pool
Publikováno v:
ACS Medicinal Chemistry Letters. 5:679-684
Nucleoside analogues have long been recognized as prospects for the discovery of direct acting antivirals (DAAs) to treat hepatitis C virus because they have generally exhibited cross-genotype activity and a high barrier to resistance. C-Nucleosides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2b73cd6b0e37544386aa833a0c233c
https://doi.org/10.1021/ml500077j
https://doi.org/10.1021/ml500077j
Publikováno v:
The Journal of Organic Chemistry. 68:989-992
We report efficient syntheses of the clinical agent cladribine (2-chloro-2'-deoxyadenosine, CldAdo), which is the drug of choice against hairy-cell leukemia and other neoplasms, from 2'-deoxyguanosine. Treatment of 3',5'-di-O-acetyl- or benzoyl-2'-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0e19d76c402107c49b264e7d4e8464
https://doi.org/10.1021/jo020644k
https://doi.org/10.1021/jo020644k
Autor:
Morris J. Robins, Paula Francom
Publikováno v:
The Journal of Organic Chemistry. 68:666-669
Treatment of 9-(2,3,5-tri-O-acetyl-beta-d-ribofuranosyl)-2-amino-6-chloropurine (1) with TMS-Cl and benzyltriethylammonium nitrite (BTEA-NO2) in dichloromethane gave the crystalline 2,6-dichloropurine nucleoside 2, and acetyl chloride/BTEA-NO2 was eq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2106863075a35d73bc51435f48e4a5a
https://doi.org/10.1021/jo020625a
https://doi.org/10.1021/jo020625a
Publikováno v:
The Journal of Organic Chemistry. 67:6788-6796
Nonaqueous diazotization-dediazoniation of two types of aminopurine nucleoside derivatives has been investigated. Treatment of 9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-2-amino-6-chloropurine (1) with SbCl(3)/CH(2)Cl(2) was examined with benzyltrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22d378e1d48163660f0deced7d727316
https://doi.org/10.1021/jo0204101
https://doi.org/10.1021/jo0204101
Publikováno v:
Journal of Medicinal Chemistry. 39:1836-1845
The synthesis and biological activity of 42 6-substituted-2,4-diaminopyrido[3,2-d]pyrimidines (2,4-diamino-8-deazafolate analogues) are reported. The compounds were synthesized in improved yields compared to previous classical analogues using modific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a00fd10a3d846728a2b5c6a149a4780
https://doi.org/10.1021/jm950918e
https://doi.org/10.1021/jm950918e
Publikováno v:
ChemInform. 27
The synthesis and biological activity of 42 6-substituted-2,4-diaminopyrido[3,2-d]pyrimidines (2,4-diamino-8-deazafolate analogues) are reported. The compounds were synthesized in improved yields c...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07d39b795e791dbc32ab0b4a7013e12a
https://doi.org/10.1002/chin.199633173
https://doi.org/10.1002/chin.199633173
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d38657e716c74204efa3154673863042
https://doi.org/10.1002/chin.199913261
https://doi.org/10.1002/chin.199913261
Autor:
Paula, Francom, Morris J, Robins
Publikováno v:
The Journal of organic chemistry. 68(2)
Treatment of 9-(2,3,5-tri-O-acetyl-beta-d-ribofuranosyl)-2-amino-6-chloropurine (1) with TMS-Cl and benzyltriethylammonium nitrite (BTEA-NO2) in dichloromethane gave the crystalline 2,6-dichloropurine nucleoside 2, and acetyl chloride/BTEA-NO2 was eq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed7c115615dca17cfb843d511c269362
https://pubmed.ncbi.nlm.nih.gov/12530909
https://pubmed.ncbi.nlm.nih.gov/12530909
Publikováno v:
The Journal of organic chemistry. 67(19)
Nonaqueous diazotization-dediazoniation of two types of aminopurine nucleoside derivatives has been investigated. Treatment of 9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-2-amino-6-chloropurine (1) with SbCl(3)/CH(2)Cl(2) was examined with benzyltrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d438127b04bdcb5b5c092811db380ad1
https://pubmed.ncbi.nlm.nih.gov/12227811
https://pubmed.ncbi.nlm.nih.gov/12227811