Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Paula E. Park"'
Autor:
Joel E. Schlosburg, Scott Edwards, Gery Schulteis, Leandro F. Vendruscolo, Paula E. Park, George F. Koob
Publikováno v:
Addiction Biology. 20:275-284
Opioids represent effective drugs for the relief of pain, yet chronic opioid use often leads to a state of increased sensitivity to pain that is exacerbated during withdrawal. A sensitization of pain-related negative affect has been hypothesized to c
Autor:
Leandro F. Vendruscolo, Joel E. Schlosburg, Timothy W. Whitfield, Olivier George, George F. Koob, Paula E. Park, Elena Crawford
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 33, iss 49
The abuse of opioid drugs, both illicit and prescription, is a persistent problem in the United States, accounting for >1.2 million users who require treatment each year. Current treatments rely on suppressing immediate withdrawal symptoms and replac
Autor:
Leandro F. Vendruscolo, Gery Schulteis, Scott Edwards, Paula E. Park, Jesse R. Schank, Kejun Cheng, Estelle Barbier, Nathan Juergens, George F. Koob, Kaushik K. Misra, Markus Heilig, Kenner C. Rice, Joel E. Schlosburg
Publikováno v:
Neuropsychopharmacology. 38:976-984
Genetic deletion of the neurokinin 1 receptor (NK1R) has been shown to decrease the reinforcing properties of opioids, but it is unknown whether pharmacological NK1R blockade has the same effect. Here, we examined the effect of L822429, a rat-specifi
Autor:
Scott Edwards, Joel E. Schlosburg, George F. Koob, Gery Schulteis, Paula E. Park, Leandro F. Vendruscolo
Publikováno v:
The international journal of neuropsychopharmacology. 16(8)
Anxiety is one of the early symptoms of opioid withdrawal and contributes to continued drug use and relapse. The acoustic startle response (ASR) is a component of anxiety that has been shown to increase during opioid withdrawal in both humans and ani
Autor:
Carrie L. Wade, Scott Edwards, Paula E. Park, Brooke E. Schmeichel, Timothy W. Whitfield, Ami Cohen, Joel E. Schlosburg, Cara L. Buck, George F. Koob, Leandro F. Vendruscolo, Olivier George
Publikováno v:
Neuropharmacology.
Drug addiction has been conceptualized as a chronically relapsing disorder of compulsive drug seeking and taking that progresses through three stages: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. Drug addiction impa
Autor:
Kaushik K. Misra, Leandro F. Vendruscolo, Sunmee Wee, Gery Schulteis, Paula E. Park, Scott Edwards, Joel E. Schlosburg, George F. Koob
Animal models of drug dependence have described both reductions in brain reward processes and potentiation of stress-like (or anti-reward) mechanisms, including a recruitment of corticotropin-releasing factor (CRF) signaling. Accordingly, chronic exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a236231d83bbad170e92fae4a5893904
https://europepmc.org/articles/PMC3262951/
https://europepmc.org/articles/PMC3262951/
Autor:
Paula E. Park, John P. Durbin, Martin Weber, Wei Li Chang, Robert H. Mach, Robert T. Luedtke, Neal R. Swerdlow
Publikováno v:
Pharmacology, biochemistry, and behavior. 93(2)
Prepulse inhibition of startle (PPI) is an operational measure of sensorimotor gating that is impaired in schizophrenia. Treatment with mixed dopamine D2/D3 antagonists diminishes schizophrenia symptoms, and opposes dopamine agonist-induced PPI defic