Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Paula Deschamps"'
Autor:
Vanessa B. Martino, Thomas Sabljic, Paula Deschamps, Rebecca M. Green, Monica Akula, Erica Peacock, Alexander Ball, Trevor Williams, Judith A. West-Mays
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 8, Pp 849-861 (2016)
Anterior segment dysgenesis (ASD) encompasses a group of developmental disorders in which a closed angle phenotype in the anterior chamber of the eye can occur and 50% of patients develop glaucoma. Many ASDs are thought to involve an inappropriate pa
Externí odkaz:
https://doaj.org/article/4cdfc075073c4fa58b4f0cbdb6e77bdf
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8730, p 8730 (2021)
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8730, p 8730 (2021)
The cornea is an anterior eye structure specialized for vision. The corneal endothelium and stroma are derived from the periocular mesenchyme (POM), which originates from neural crest cells (NCCs), while the stratified corneal epithelium develops fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87524c6a761c850fb23dd92db270b2a
Autor:
Anthony Saraco, Trevor Williams, Aftab Taiyab, Alexander K. Ball, Paula Deschamps, Monica Akula, Judith A. West-Mays
Publikováno v:
Curr Eye Res
PURPOSE: Our lab has shown that conditionally disrupting the transcription factor activating protein 2β (Tfap2b) gene, responsible for the activating protein-2β (AP-2β) transcription factor, exclusively in cranial neural crest cells (AP-2β NCC KO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7aface918af82037902d70cfc6465e
https://pubmed.ncbi.nlm.nih.gov/33689532
https://pubmed.ncbi.nlm.nih.gov/33689532
Autor:
Monica Akula, Judith A. West-Mays, Paula Deschamps, Shannin Yee, Aftab Taiyab, Alexander K. Ball, Trevor Williams
Publikováno v:
Exp Eye Res
Previously, we have shown that Tfap2b, the gene encoding transcription factor AP-2β, is needed for normal mouse eye development. Specifically, targeted loss of Tfap2b in neural crest cells (NCCs)(1) and their derivatives, particularly the periocular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bae4305c9b65e6ed016a5643fd5f8f0
https://pubmed.ncbi.nlm.nih.gov/32353428
https://pubmed.ncbi.nlm.nih.gov/32353428
Autor:
Trevor Williams, Michael D. Noseworthy, Judith A. West-Mays, Emily Anne Hicks, Mizna Zaveri, Paula Deschamps, Alexander K. Ball
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The combined action of the activating protein-2 (AP-2) transcription factors, AP-2α and AP-2β, is important in early retinal development, specifically in the formation of horizontal cells. However, in previous studies, it was not possible t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510c41c1e3cb0ddf445d7dda77ab9b3c
http://europepmc.org/articles/PMC5931233
http://europepmc.org/articles/PMC5931233
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Transforming growth factor-β-induced epithelial-mesenchymal transition (EMT) is one of the main causes of posterior capsular opacification (PCO) or secondary cataract; however, the signaling events involved in TGF-β-induced PCO have not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba28fef958f82fc0d300d037a28f1f8
http://europepmc.org/articles/PMC5089212
http://europepmc.org/articles/PMC5089212
Autor:
Jennifer Robertson, Dhruva J. Dwivedi, Paula Deschamps, Judith A. West-Mays, Anna Korol, G. Pino
Publikováno v:
The American Journal of Pathology. 184(7):2001-2012
Epithelial-mesenchymal transition (EMT) is associated with fibrotic diseases in the lens, such as anterior subcapsular cataract (ASC) formation. Often mediated by transforming growth factor (TGF)-β, EMT in the lens involves the transformation of len
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94875b00f928d2c9c9451f14872e643
Autor:
Erica Peacock, Rebecca M. Green, Thomas F. Sabljic, Trevor Williams, Vanessa Martino, Alexander K. Ball, Judith A. West-Mays, Monica Akula, Paula Deschamps
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 8, Pp 849-861 (2016)
Disease Models & Mechanisms
Disease Models & Mechanisms
Anterior segment dysgenesis (ASD) encompasses a group of developmental disorders in which a closed angle phenotype in the anterior chamber of the eye can occur and 50% of patients develop glaucoma. Many ASDs are thought to involve an inappropriate pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab94acdfcb94a6bb33e1b2cd265156a
https://doi.org/10.1242/dmm.025262
https://doi.org/10.1242/dmm.025262
Autor:
Judith A. West-Mays, Reinhard Buettner, Erin A. Bassett, Anna Korol, Valerie A. Wallace, Trevor Williams, Paula Deschamps
Publikováno v:
Developmental Dynamics. 241:814-829
Background: We have previously shown that the transcription factor AP-2α (Tcfap2a) is expressed in postmitotic developing amacrine cells in the mouse retina. Although retina-specific deletion of Tcfap2a did not affect retinogenesis, two other family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6b1ec3b6388dc36ff7df9caf6bce29
https://doi.org/10.1002/dvdy.23762
https://doi.org/10.1002/dvdy.23762
Autor:
Shelley Sullivan, Ales Cvekl, Trevor Williams, Paula Deschamps, Ruth Ashery-Padan, Judith A. West-Mays, Ryan Wong, Giuseppe F. Pontoriero, Jiri Zavadil, Ying Yang
Publikováno v:
Developmental Dynamics. 237:602-617
In this study, we have created a conditional deletion of AP-2alpha in the developing mouse lens (Le-AP-2alpha mutants) to determine the cell-autonomous requirement(s) for AP-2alpha in lens development. Embryonic and adult Le-AP-2alpha mutants exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120e68366a22a0c48efe8adadbe28d1f
https://doi.org/10.1002/dvdy.21445
https://doi.org/10.1002/dvdy.21445