Výsledky vyhledávání - "Paula D. Nathaniel"

Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury

Autor: Simon C. Watkins, Csaba Szabó, Larry W. Jenkins, Patrick M. Kochanek, Yi-Chen Lai, Fengli Guo, Robert S. B. Clark, Yaming Chen, Paula D. Nathaniel

Publikováno v: Journal of Neurochemistry. 104:1700-1711

Poly-ADP-ribosylation is a post-translational modification performed by poly(ADP-ribose) polymerases (PARP), involved in many diverse cellular functions including DNA repair, transcription, and long-term potentiation. Paradoxically, PARP over-activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::686e93ed07a6b3c1f4d26955918af90e
https://doi.org/10.1111/j.1471-4159.2007.05114.x

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Local Administration of the Poly(ADP-Ribose) Polymerase Inhibitor INO-1001 Prevents NAD+ Depletion and Improves Water Maze Performance after Traumatic Brain Injury in Mice

Autor: Csaba Szabó, Larry W. Jenkins, Paula D. Nathaniel, C. Edward Dixon, Robert S. B. Clark, Vincent Vagni

Publikováno v: Journal of Neurotrauma. 24:1399-1405

Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme best known for its role in DNA repair and as a mediator of NAD+ depletion and energy failure-induced cell death. We tested the effect of the potent and selective ideno-isoquinolone PARP-1 inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19f8a369a7ea4c680ab5c82da419efb
https://doi.org/10.1089/neu.2007.0305

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Intranuclear localization of apoptosis-inducing factor (AIF) and large scale dna fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite

Autor: Jun Chen, Lina Du, Fengli Guo, Steven H. Graham, Paula D. Nathaniel, Patrick M. Kochanek, Simon C. Watkins, Xiaopeng Zhang, Romesh Draviam, Robert S. B. Clark, Csaba Szabó

Publikováno v: Journal of Neurochemistry. 82:181-191

Programmed cell death occurs after ischemic, excitotoxic, and traumatic brain injury (TBI). Recently, a caspase-independent pathway involving intranuclear translocation of mitochondrial apoptosis-inducing factor (AIF) has been reported in vitro; but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9007cf45de177df0c2dcc1816fc950b5
https://doi.org/10.1046/j.1471-4159.2002.00975.x

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Caspase-3 Mediated Neuronal Death After Traumatic Brain Injury in Rats

Autor: Robert S. B. Clark, Neal A. Seidberg, Kunlin Jin, Patrick M. Kochanek, Paula D. Nathaniel, Minzhi Chen, Simon C. Watkins, John A. Melick, Steven H. Graham, J. E. Loeffert, C. E. Dixon

Publikováno v: Journal of Neurochemistry. 74:740-753

During programmed cell death, activation of caspase-3 leads to proteolysis of DNA repair proteins, cytoskeletal proteins, and the inhibitor of caspase-activated deoxyribonuclease, culminating in morphologic changes and DNA damage defining apoptosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deed6659bfe42eeca1b1f58cb1f0241e
https://doi.org/10.1046/j.1471-4159.2000.740740.x

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Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury

Autor: Yichen, Lai, Yaming, Chen, Simon C, Watkins, Paula D, Nathaniel, Fengli, Guo, Patrick M, Kochanek, Larry W, Jenkins, Csaba, Szabó, Robert S B, Clark

Publikováno v: Journal of neurochemistry. 104(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5e01f08ddc021063858f475591397a9
https://pubmed.ncbi.nlm.nih.gov/17996029

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boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats

Autor: Simon C. Watkins, Sean Alber, Patrick M. Kochanek, Steven H. Graham, Robert S. B. Clark, C. Edward Dixon, Xiaopeng Zhang, Paula D. Nathaniel, John A. Melick

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 27(2)

The pathobiology of traumatic brain injury (TBI) includes activation of multiple caspases followed by cell death with a spectrum of apoptotic phenotypes. There are initiator (e.g. caspase-2, −8, and −9) and effector (e.g. caspase-3 and −7) casp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6662aa0abb0c61dacee58b3b61b0c6e1
https://pubmed.ncbi.nlm.nih.gov/16736044

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Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats

Autor: Patrick M. Kochanek, Milos D. Ikonomovic, Donald W. Marion, Xiaopeng Zhang, Steven T. DeKosky, Robert S. B. Clark, Paula D. Nathaniel, Larry W. Jenkins, Yarning Chen

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 26(7)

Activation of protein kinase B (PKB, also known as Akt) by phosphorylation at serine-473 and threonine-308 promotes cell survival in multiple in vitro and in vivo models where neuronal death is seen, including traumatic brain injury (TBI); however, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed46a42f2a178b7d761daba66379bb17
https://pubmed.ncbi.nlm.nih.gov/16234845

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Caspase-8 expression and proteolysis in human brain after severe head injury

Autor: Xiaopeng Zhang, Paula D. Nathaniel, Patrick M. Kochanek, Simon C. Watkins, Donald W. Marion, Robert S. B. Clark, Steven H. Graham

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17(10)

Programmed cell death involves a complex and interrelated cascade of cysteine proteases termed caspases that are synthesized as inactive zymogens, which are proteolytically processed to active enzymes. Caspase-8 is an initiator caspase that becomes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ed408eac302d4777ef1279685b6198
https://pubmed.ncbi.nlm.nih.gov/12738800

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Detection of single- and double-strand DNA breaks after traumatic brain injury in rats: comparison of in situ labeling techniques using DNA polymerase I, the Klenow fragment of DNA polymerase I, and terminal deoxynucleotidyl transferase

Autor: Minzhi Chen, Kunlin Jin, Simon C. Watkins, Donald W. Marion, Steven H. Graham, Romesh Draviam, Robert S. B. Clark, Rodnina Pinto, Patrick M. Kochanek, Paula D. Nathaniel

Publikováno v: Journal of neurotrauma. 18(7)

DNA damage is a common sequela of traumatic brain injury (TBI). Available techniques for the in situ identification of DNA damage include DNA polymerase I-mediated biotin-dATP nick-translation (PANT), the Klenow fragment of DNA polymerase I-mediated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25fa0df373ce9350c7594e866e8649b
https://pubmed.ncbi.nlm.nih.gov/11497094

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