Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Paula C. Ortet"'
Autor:
Aaron B. Beeler, Karen N. Allen, Paula C Ortet, Samantha N Muellers, Blair R. Szymczyna, Lauren A Viarengo-Baker, Kristina Streu, Adrian Whitty
Publikováno v:
Journal of the American Chemical Society. 143:3779-3793
Macrocycles, including macrocyclic peptides, have shown promise for targeting challenging protein-protein interactions (PPIs). One PPI of high interest is between Kelch-like ECH-Associated Protein-1 (KEAP1) and Nuclear Factor (Erythroid-derived 2)-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aeb66c0f3ef819fef5bc8572ab7fedc
https://doi.org/10.1021/jacs.0c09799
https://doi.org/10.1021/jacs.0c09799
Autor:
Brian H. White, Yaguang Si, Sarah Cappucci, Zhi Li, Jessica D. Ramirez, Charles M. Ponthier, Erica Visness, Peicheng Du, Minjung Choi, Pieter C. Beerepoot, Paula C. Ortet, Ivan T. Jewett, Josue Alfaro-Lopez, Sorabh Agarwal, Daniel La, Aaron Fulgham, John H. McGee, Keith Orford, Jonathan B. Hurov, Martin R. Tremblay, Gregory L. Verdine
Publikováno v:
Cancer Research. 83:3094-3094
Wnt signaling pathway mutations leading to constitutive activation of the driver oncogene β-catenin occur in at least 20% of all human cancers, but β-catenin itself has remained undruggable by traditional modalities. In order to inhibit the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c51d264aae8f3a219530f16aa966065
https://doi.org/10.1158/1538-7445.am2023-3094
https://doi.org/10.1158/1538-7445.am2023-3094