Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Paula C Bickford"'
Autor:
Md Shahaduzzaman, Kevin Nash, Charles Hudson, Masroor Sharif, Bethany Grimmig, Xiaoyang Lin, Ge Bai, Hui Liu, Kenneth E Ugen, Chuanhai Cao, Paula C Bickford
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116841 (2015)
The protein α-synuclein (α-Syn) has a central role in the pathogenesis of Parkinson's disease (PD) and immunotherapeutic approaches targeting this molecule have shown promising results. In this study, novel antibodies were generated against specifi
Externí odkaz:
https://doaj.org/article/3048b44df2f042b78f1e8c7e5a1053b4
Autor:
Sandra A Acosta, Naoki Tajiri, Kazutaka Shinozuka, Hiroto Ishikawa, Bethany Grimmig, David M Diamond, Paul R Sanberg, Paula C Bickford, Yuji Kaneko, Cesar V Borlongan
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53376 (2013)
The long-term consequences of traumatic brain injury (TBI), specifically the detrimental effects of inflammation on the neurogenic niches, are not very well understood. In the present in vivo study, we examined the prolonged pathological outcomes of
Externí odkaz:
https://doaj.org/article/3b0f0ab8d22c4d6daf1942aec6ffd188
Publikováno v:
Brain Sciences, Vol 6, Iss 4, p 41 (2016)
Parkinson’s disease (PD) is a common neurodegenerative disorder that primarily afflicts the elderly. It is characterized by motor dysfunction due to extensive neuron loss in the substantia nigra pars compacta. There are multiple biological processe
Externí odkaz:
https://doaj.org/article/1916fd2b918d4d86b92c9ed939e9cd12
Autor:
Naoki Tajiri, Sandra Acosta, Loren E Glover, Paula C Bickford, Alejandra Jacotte Simancas, Takao Yasuhara, Isao Date, Marianna A Solomita, Ivana Antonucci, Liborio Stuppia, Yuji Kaneko, Cesar V Borlongan
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43779 (2012)
We recently reported isolation of viable rat amniotic fluid-derived stem (AFS) cells [1]. Here, we tested the therapeutic benefits of AFS cells in a rodent model of ischemic stroke. Adult male Sprague-Dawley rats received a 60-minute middle cerebral
Externí odkaz:
https://doaj.org/article/4510cf031aa14026913dfb25bd1eb228
Autor:
Mibel M Pabon, Jennifer N Jernberg, Josh Morganti, Jessika Contreras, Charles E Hudson, Ronald L Klein, Paula C Bickford
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45256 (2012)
Inflammation in the brain plays a major role in neurodegenerative diseases. In particular, microglial cell activation is believed to be associated with the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). An increase in
Externí odkaz:
https://doaj.org/article/682193a7fb3a468c8a854fb92f4c812f
Autor:
Adam D Bachstetter, Jennifer Jernberg, Andrea Schlunk, Jennifer L Vila, Charles Hudson, Michael J Cole, R Douglas Shytle, Jun Tan, Paul R Sanberg, Cyndy D Sanberg, Cesario Borlongan, Yuji Kaneko, Naoki Tajiri, Carmelina Gemma, Paula C Bickford
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10496 (2010)
Adult stem cells are present in many tissues including, skin, muscle, adipose, bone marrow, and in the brain. Neuroinflammation has been shown to be a potent negative regulator of stem cell and progenitor cell proliferation in the neurogenic regions
Externí odkaz:
https://doaj.org/article/9e7913c1b5744b24a65dbca442f2a60a
Autor:
Svitlana Garbuzova-Davis, Cyndy Davis Sanberg, Nicole Kuzmin-Nichols, Alison E Willing, Carmelina Gemma, Paula C Bickford, Christina Miller, Robert Rossi, Paul R Sanberg
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2494 (2008)
Amyotrophic Lateral Sclerosis (ALS) is a multicausal disease characterized by motor neuron degeneration in the spinal cord and brain. Cell therapy may be a promising new treatment for this devastating disorder. We recently showed that a single low do
Externí odkaz:
https://doaj.org/article/b13ef9c08eee463aaf5d3cc20d9f7dba
Autor:
Rekha S. Patel, Ashley Lui, Charles Hudson, Lauren Moss, Robert P. Sparks, Shannon E. Hill, Yan Shi, Jianfeng Cai, Laura J. Blair, Paula C. Bickford, Niketa A. Patel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Shifts in normal aging set stage for neurodegeneration and dementia affecting 1 in 10 adults. The study demonstrates that lncRNA GAS5 is decreased in aged and Alzheimer’s disease brain. The role and targets of lncRNA GAS5 in the aging brai
Externí odkaz:
https://doaj.org/article/7e1cfc1749fc453bb56dae844a64cc03
Autor:
Ryan Green, Karthick Mayilsamy, Andrew R. McGill, Taylor E. Martinez, Bala Chandran, Laura J. Blair, Paula C. Bickford, Shyam S. Mohapatra, Subhra Mohapatra
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 217-229 (2022)
The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000 infections globally thus far. Up to 30% of individuals with mild to severe disease develop long COVID, exhibiting diverse neurologic symptoms including dementias. However, t
Externí odkaz:
https://doaj.org/article/f5788a47b7924c8db7fe23ddaa442896
Autor:
Dylan Finneran, Qingyou Li, Meena S. Subbarayan, Aurelie Joly‐Amado, Siddharth Kamath, Daniela G. Dengler, Marcia N. Gordon, Michael R. Jackson, Dave Morgan, Paula C. Bickford, Layton H. Smith, Kevin R. Nash
Publikováno v:
GliaREFERENCES. 71(2)
Fractalkine (FKN) is a membrane-bound chemokine that can be cleaved by proteases such as ADAM 10, ADAM 17, and cathepsin S to generate soluble fragments. Studies using different forms of the soluble FKN yield conflicting results in vivo. These observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a625c1f405b3c2651058e648b96a88
https://pubmed.ncbi.nlm.nih.gov/36106533
https://pubmed.ncbi.nlm.nih.gov/36106533