Výsledky vyhledávání - "Paula B. van Hennik"

Akademický článek

A Comparison of Post-marketing Measures Imposed by Regulatory Agencies to Confirm the Tissue-Agnostic Approach

Autor: Jorn Mulder, Odile C. van Stuijvenberg, Paula B. van Hennik, Emile E. Voest, Anna M. G. Pasmooij, Violeta Stoyanova-Beninska, Anthonius de Boer

Publikováno v: Frontiers in Medicine, Vol 9 (2022)

There are currently four anti-cancer medicinal products approved for a tissue-agnostic indication. This is an indication based on a common biological characteristic rather than the tissue of origin. To date, the regulatory experience with tissue-agno

Externí odkaz: https://doaj.org/article/bef9992941e84c2bb5b56da3c1c101f1

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Akademický článek

Factors affecting the feasibility of post-authorisation RCTs for conditionally authorised anticancer medicines: a multistakeholder perspective from a qualitative focus group study

Autor: Gabe S Sonke, Amos J de Jong, Lourens T Bloem, Christine C van Hattem, Jolien S de Groot, Jarno Hoekman, K Esther Broekman, Paula B van Hennik

Publikováno v: BMJ Open, Vol 14, Iss 11 (2024)

Objective The collection of comprehensive data from post-authorisation trials for conditionally authorised anticancer medicines is frequently delayed. This raises questions about the feasibility of post-authorisation randomised controlled trials (RCT

Externí odkaz: https://doaj.org/article/4fe87bd87ee346fdb277817cb56dabf2

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European Conditional Marketing Authorization in a Rapidly Evolving Treatment Landscape: A Comprehensive Study of Anticancer Medicinal Products in 2006-2020

Autor: Lourens T. Bloem, Jasmin Schelhaas, Lucía López‐Anglada, Carla Herberts, Paula B. van Hennik, Olli Tenhunen

Since 2006, the European conditional marketing authorization (CMA) aims to facilitate timely patient access to medicinal products for which there is an unmet medical need by accepting less comprehensive data than normally required. The granting of CM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4135e212be33e6200812c4b1f281a967
https://dspace.library.uu.nl/handle/1874/429487

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The EMA Assessment of Asciminib for the Treatment of Adult Patients With Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase Who Were Previously Treated With At Least 2 Tyrosine Kinase Inhibitors

Autor: C Mircea S Tesileanu, Sotirios Michaleas, Rocio Gonzalo Ruiz, Segundo Mariz, Babs O Fabriek, Paula B van Hennik, Jutta Dedorath, Bruna Dekic, Christoph Unkrig, Andreas Brandt, Janet Koenig, Harald Enzmann, Julio Delgado, Francesco Pignatti

Publikováno v: The Oncologist.

Asciminib is an allosteric high-affinity tyrosine kinase inhibitor (TKI) of the BCR-ABL1 protein kinase. This kinase is translated from the Philadelphia chromosome in chronic myeloid leukemia (CML). Marketing authorization for asciminib was granted o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c63cc82945dfe47663d28d096426a43d
https://doi.org/10.1093/oncolo/oyad119

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Rho GTPases in hematopoietic cells

Autor: Paula B. van Hennik, Peter L. Hordijk

Publikováno v: Van Hennik, P B & Hordijk, P L 2005, ' Rho GTPases in hematopoietic cells ', Antioxidants and Redox Signaling, vol. 7, no. 11-12, pp. 1440-1455 . https://doi.org/10.1089/ars.2005.7.1440

The ubiquitous Rho GTPases are instrumental in the organization of the actin cytoskeleton, but also for the control of gene expression. Here we review the role of the major members of this family, i.e., RhoA, Rac1, Rac2, and Cdc42, and their intracel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c7008386a7541e5949c53397ee02f4
https://doi.org/10.1089/ars.2005.7.1440

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Somatostatin is a selective chemoattractant for primitive (CD34+) hematopoietic progenitor cells

Autor: Sigrid P M A Oomen, Paula B. van Hennik, Leo J. Hofland, Ivo P. Touw, Steven W. J. Lamberts, Claudia Antonissen, Bob Löwenberg, Elgin G. R. Lichtenauer-Kaligis

Publikováno v: Experimental Hematology, 30(2), 116-125. Elsevier Inc.

Objective Somatostatin (SST) is a regulatory peptide with a wide variety of activities in different tissues. SST activates G αi -protein-coupled receptors of a family comprising five members (SSTR1–5). Despite the broad use of SST and its analogs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16db220f94edd8b09ff41039a8bd71b
https://doi.org/10.1016/s0301-472x(01)00772-x

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Stroma-supported progenitor production as a prognostic tool for graft failure following autologous stem cell transplantation

Autor: Martin R. Schipperus, Ineke Slaper-Cortenbach, Dimitri Breems, Nuray Kusadasi, Paula B. van Hennik, Hans van der Lelie, Henk van den Berg, Rob E. Ploemacher, Jan J. Cornelissen

Publikováno v: British Journal of Haematology. 111:674-684

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c0423c8082112e0eb7826e1114536b6
https://doi.org/10.1111/j.1365-2141.2000.02351.x

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Highly Efficient Transduction of the Green Fluorescent Protein Gene in Human Umbilical Cord Blood Stem Cells Capable of Cobblestone Formation in Long-Term Cultures and Multilineage Engraftment of Immunodeficient Mice

Autor: Ana Limón, Jose A. Cancelas, Paula B. van Hennik, Gerard Wagemaker, Rob E. Ploemacher, A. W. Wognum, Marti F.A. Bierhuizen, Monique M A Verstegen, Jordi Barquinero

Publikováno v: Blood, 92(11), 4013-4022. American Society of Hematology

Purified CD34+ and CD34+CD38− human umbilical cord blood (UCB) cells were transduced with the recombinant variant of Moloney murine leukemia virus (MoMLV) MFG-EGFP or with SF-EGFP, in which EGFP expression is driven by a hybrid promoter of the sple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15abf64bd7cee151cf65b5cf12ba3124
https://doi.org/10.1182/blood.v92.11.4013.423k53_4013_4022

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Transplantation of Human Umbilical Cord Blood Cells in Macrophage-Depleted SCID Mice: Evidence for Accessory Cell Involvement in Expansion of Immature CD34+CD38−Cells

Autor: Nico van Rooijen, Wim Terpstra, Paula B. van Hennik, Rob E. Ploemacher, Gerard Wagemaker, Jenne J. Wielenga, Cor van den Bos, Monique M A Verstegen, Albertus W. Wognum

Publikováno v: Blood, 91(6), 1966-1976. American Society of Hematology

In vivo expansion and multilineage outgrowth of human immature hematopoietic cell subsets from umbilical cord blood (UCB) were studied by transplantation into hereditary immunodeficient (SCID) mice. The mice were preconditioned with Cl2MDP-liposomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62afeda42cb1fd017fa419bce10f070f
https://doi.org/10.1182/blood.v91.6.1966

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Nucleophosmin1 is a negative regulator of the small GTPase Rac1

Autor: Peter L. Hordijk, Paula B. van Hennik, Anne M. van Stalborgh, Younes Zoughlami

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68477 (2013)
PLoS ONE
PLoS ONE, 8(7). Public Library of Science
Zoughlami, Y, van Stalborgh, A M, van Hennik, P B & Hordijk, P L 2013, ' Nucleophosmin1 Is a Negative Regulator of the Small GTPase Rac1 ', PLoS ONE, vol. 8, no. 7, e68477 . https://doi.org/10.1371/journal.pone.0068477
PLoS ONE, 8(7):e68477. Public Library of Science

The Rac1 GTPase is a critical regulator of cytoskeletal dynamics and controls many biological processes, such as cell migration, cell-cell contacts, cellular growth and cell division. These complex processes are controlled by Rac1 signaling through e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a075300fcc86e7f46d7776801ab2d46
http://europepmc.org/articles/PMC3713031?pdf=render

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