Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Paula A. Zacharowski"'
Autor:
Olaf Boehm, Kai Zacharowski, William C. Claycomb, Reinhard Berkels, Jan Mersmann, Alexander Koch, Kazuma Iekushi, Stefanie Dimmeler, Paula A. Zacharowski, Tiago Granja, Nguyen Tran
Publikováno v:
Critical Care Medicine. 38:903-909
To test whether preconditioning with a toll-like receptor (TLR) 2 agonist protects against myocardial ischemia and reperfusion by interfering with chemokine CXCL1 release from cardiomyocytes.C3H mice were challenged with vehicle or synthetic TLR2 ago
Autor:
Rene Schmidt, Paula A. Zacharowski, Jörg Weimann, Reinhard Berkels, Alexander Koch, Kai Zacharowski, Olaf Boehm, Hauke Rensing, Stephan A. Loer, Sonja Reingruber, Simon J. Foster
Publikováno v:
Critical Care Medicine. 35:2775-2784
Pretreatment with low-dose lipopolysaccharide protects cells/organs against a subsequent lethal Gram-negative (lipopolysaccharide tolerance) or Gram-positive (cross tolerance) stimulus. We determined whether this occurs in the rat lung. The involveme
Autor:
Kai Zacharowski, Olaf Boehm, Alexander Koch, Reinhard Berkels, Stafford L. Lightman, Matthias Schott, Stefan R. Bornstein, Pascal Knuefermann, Georg Baumgarten, Nguyen Tran, Waldemar Kanczkowski, Paula A. Zacharowski
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:2773-2783
Context: Sepsis is a leading cause of death in the Western world and can be associated with failure of the hypothalamic-pituitary-adrenal axis. A coordinated response of the adrenal and immune system is of vital importance for survival during sepsis.
Autor:
Kai Zacharowski, Olaf Boehm, Jef J. Emeis, Paula A. Zacharowski, Sonja Reingruber, Peter Friedl, Peter Petzelbauer, Alexander Koch, Rainer Henning, Parissa Mastan, Russell P. Rother
Publikováno v:
Shock. 27:631-637
Many compounds have been shown to prevent reperfusion injury in various animal models, although to date, translation into clinic has revealed several obstacles. Therefore, the National Heart, Lung, and Blood Institute convened a working group to disc
Publikováno v:
Journal of Molecular Medicine. 84:469-477
The occlusion of a coronary artery leads to ischemia of the myocardium, while permanent occlusion results in cell death and myocardial dysfunction. Early restoration of blood flow is the only means to reduce or prevent myocardial necrosis, but-parado
Publikováno v:
Thrombosis and Haemostasis. 95:557-561
SummaryDuring Gram-negative sepsis, lipopolysaccharide (LPS) activates toll-like receptor (TLR) 4 and induces complex responses of immune system and haemostasis. In the present study we investigated whether thrombelastography is suitable to monitor t
Autor:
Marion Gröger, Klaus Wolff, Peter Petzelbauer, Georg Wickenhauser, Paula A. Zacharowski, Kai Zacharowski, Francis J. Castellino, Peter Friedl, Yasuhiro Miyazaki
Publikováno v:
Nature Medicine. 11:298-304
In the event of a myocardial infarction, current interventions aim to reopen the occluded vessel to reduce myocardial damage and injury. Although reperfusion is essential for tissue salvage, it can cause further damage and the onset of inflammation.
Autor:
Stefan R. Bornstein, Claudia Papewalis, Kai Zacharowski, Klaus Schulze-Osthoff, Nguyen Tran, Paula A. Zacharowski, Jörg Tarnow, Werner A. Scherbaum, Samuel M. McCann, Andreas Barthel, Valeria Rettori, Ralf R. Schumann
Publikováno v:
Proceedings of the National Academy of Sciences. 101:16695-16700
Septicemia is one of the major health concerns worldwide, and rapid activation of adrenal steroid release is a key event in the organism's first line of defense during this form of severe illness. The family of Toll-like receptors (TLRs) is critical
Autor:
Kai Zacharowski, Paula A. Zacharowski
Publikováno v:
Critical Care Medicine. 34:567-569
Publikováno v:
Shock (Augusta, Ga.). 30(1)
The peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a regulator of anti-inflammatory genes. One of its agonists, rosiglitazone-widely used in the treatment of type 2 diabetes mellitus-has recently been reported to increase the risk f