Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Paula A. Videira"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-3 (2024)
Abstract The rapid expansion of cancer immunology and immunotherapy builds upon the success of early immune checkpoint inhibitors (ICI) and chimeric antigen receptor T cells for some cancer types. Many gaps still exist, however, in the scientific kno
Externí odkaz:
https://doaj.org/article/2738f0359b4d4f1caf9aec169d883335
Autor:
Rita Francisco, Sandra Brasil, Joana Poejo, Jaak Jaeken, Carlota Pascoal, Paula A. Videira, Vanessa dos Reis Ferreira
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract Congenital disorders of glycosylation (CDG) are a complex and heterogeneous family of rare metabolic diseases. With a clinical history that dates back over 40 years, it was the recent multi-omics advances that mainly contributed to the fast-
Externí odkaz:
https://doaj.org/article/091909c18fba460ea7072edca855db6c
Autor:
João Lopes, Dorinda Marques-da-Silva, Paula A. Videira, Alejandro K. Samhan-Arias, Ricardo Lagoa
Publikováno v:
Molecules, Vol 29, Iss 5, p 1129 (2024)
The catalytic properties of cytochrome c (Cc) have captured great interest in respect to mitochondrial physiology and apoptosis, and hold potential for novel enzymatic bioremediation systems. Nevertheless, its contribution to the metabolism of enviro
Externí odkaz:
https://doaj.org/article/27e7e27e700d4d73a4d6b53600d4a741
Autor:
Maria Monticelli, Rita Francisco, Sandra Brasil, Dorinda Marques-da-Silva, Tatiana Rijoff, Carlota Pascoal, Jaak Jaeken, Paula A. Videira, Vanessa dos Reis Ferreira
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-16 (2022)
Abstract Background Congenital disorders of glycosylation (CDG) are a large family of rare genetic diseases for which therapies are virtually nonexistent. However, CDG therapeutic research has been expanding, thanks to the continuous efforts of the C
Externí odkaz:
https://doaj.org/article/1a0260e2920f40c4a53b43d60ba5fd49
Autor:
Rita Francisco, Sandra Brasil, Carlota Pascoal, Jaak Jaeken, Merell Liddle, Paula A. Videira, Vanessa dos Reis Ferreira
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-18 (2022)
Abstract Background Congenital Disorders of Glycosylation (CDG) are a complex family of rare metabolic diseases. Robust clinical data collection faces many hurdles, preventing full CDG biological and clinical comprehension. Web-based platforms offer
Externí odkaz:
https://doaj.org/article/39f220057f1b4473a57de27ecccfae2a
Autor:
Patrícia S. Sobral, Vanessa C. C. Luz, João M. G. C. F. Almeida, Paula A. Videira, Florbela Pereira
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5908 (2023)
Computational approaches in immune-oncology therapies focus on using data-driven methods to identify potential immune targets and develop novel drug candidates. In particular, the search for PD-1/PD-L1 immune checkpoint inhibitors (ICIs) has enlivene
Externí odkaz:
https://doaj.org/article/d1c940483c3d4de6b44d968f03144f03
Autor:
Liliana R. Loureiro, Anja Feldmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Domokos Máthé, Nikolett Hegedüs, Krisztián Szigeti, Paula A. Videira, Michael Bachmann, Claudia Arndt
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-13 (2020)
Abstract Background Adapter chimeric antigen receptor (CAR) approaches have emerged has promising strategies to increase clinical safety of CAR T-cell therapy. In the UniCAR system, the safety switch is controlled via a target module (TM) which is ch
Externí odkaz:
https://doaj.org/article/a79309c630b94b63ab1652bbb82d83be
Autor:
Carlota Pascoal, Mylène A. Carrascal, Daniela F. Barreira, Rita A. Lourenço, Pedro Granjo, Ana R. Grosso, Paula Borralho, Sofia Braga, Paula A. Videira
Publikováno v:
Cancers, Vol 15, Iss 3, p 731 (2023)
Triple-negative breast cancer (TNBC) encompasses multiple entities and is generally highly aggressive and metastatic. We aimed to determine the clinical and biological relevance of Sialyl-Lewis X and A (sLeX/A)—a fucosylated glycan involved in meta
Externí odkaz:
https://doaj.org/article/e0bf0f99186c4b11b57d7f27ba9de969
Autor:
Sandra Brasil, Mariateresa Allocca, Salvador C. M. Magrinho, Inês Santos, Madalena Raposo, Rita Francisco, Carlota Pascoal, Tiago Martins, Paula A. Videira, Florbela Pereira, Giuseppina Andreotti, Jaak Jaeken, Kristin A. Kantautas, Ethan O. Perlstein, Vanessa dos Reis Ferreira
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8725 (2022)
Advances in research have boosted therapy development for congenital disorders of glycosylation (CDG), a group of rare genetic disorders affecting protein and lipid glycosylation and glycosylphosphatidylinositol anchor biosynthesis. The (re)use of kn
Externí odkaz:
https://doaj.org/article/704e22d5d0a1449cb15738d3275d4692
Autor:
Sandra Brasil, Cátia José Neves, Tatiana Rijoff, Marta Falcão, Gonçalo Valadão, Paula A. Videira, Vanessa dos Reis Ferreira
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
More than 7,000 rare diseases (RDs) exist worldwide, affecting approximately 350 million people, out of which only 5% have treatment. The development of novel genome sequencing techniques has accelerated the discovery and diagnosis in RDs. However, m
Externí odkaz:
https://doaj.org/article/d1e18d058fd94c43921098ee9f8e100c