Evaluarea calităţii reprezentării prin prisma dreptului la un proces echitabil // Assessing the quality of representation through the lens of the right to a fair trial

Autor: Paula Maria Marin

Publikováno v: Analele Ştiinţifice ale Universităţii "Al.I. Cuza" din Iaşi. Ştiinţe Juridice, Vol 70, Iss 1, Pp 271-279 (2024)

The representative, whether legally appointed or chosen by the party, has an important role to play in the shaping of a case, from the moment the case is referred to the judicial authority, until exercising the right to appeal. Thus, if representatio

Externí odkaz: https://doaj.org/article/4b0ff885dc4c4a70a67e5fa7e8db990c

Cell morphology-guided de novo hit design by conditioning GANs on phenotypic image features

Autor: Paula A. Marin Zapata, Oscar Méndez-Lucio, Tuan Le, Carsten Jörn Beese, Jörg Wichard, David Rouquié, Djork-Arné Clevert

Publikováno v: Digital Discovery. 2:91-102

Cellular morphology can be used to guide the de novo design of small molecules inducing a desired phenotype.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9790d6e65ce1caa163bb37135a43e9ed
https://doi.org/10.1039/d2dd00081d

Self-supervision advances morphological profiling by unlocking powerful image representations

Autor: Vladislav Kim, Nikolaos Adaloglou, Marc Osterland, Flavio M. Morelli, Paula A. Marin Zapata

Morphological profiling is a powerful technology that enables unbiased characterization of cellular states through image-based screening. Inspired by recent progress in self-supervised learning (SSL), we sought to explore the potential benefits of us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19f545afb9b9f2c9cc904387102410ca
https://doi.org/10.1101/2023.04.28.538691

JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations

Autor: Srinivas Niranj Chandrasekaran, Jeanelle Ackerman, Eric Alix, D. Michael Ando, John Arevalo, Melissa Bennion, Nicolas Boisseau, Adriana Borowa, Justin D. Boyd, Laurent Brino, Patrick J. Byrne, Hugo Ceulemans, Carolyn Ch’ng, Beth A. Cimini, Djork-Arne Clevert, Nicole Deflaux, John G Doench, Thierry Dorval, Regis Doyonnas, Vincenza Dragone, Ola Engkvist, Patrick W. Faloon, Briana Fritchman, Florian Fuchs, Sakshi Garg, Tamara J. Gilbert, David Glazer, David Gnutt, Amy Goodale, Jeremy Grignard, Judith Guenther, Yu Han, Zahra Hanifehlou, Santosh Hariharan, Desiree Hernandez, Shane R Horman, Gisela Hormel, Michael Huntley, Ilknur Icke, Makiyo Iida, Christina B. Jacob, Steffen Jaensch, Jawahar Khetan, Maria Kost-Alimova, Tomasz Krawiec, Daniel Kuhn, Charles-Hugues Lardeau, Amanda Lembke, Francis Lin, Kevin D. Little, Kenneth R. Lofstrom, Sofia Lotfi, David J. Logan, Yi Luo, Franck Madoux, Paula A. Marin Zapata, Brittany A. Marion, Glynn Martin, Nicola Jane McCarthy, Lewis Mervin, Lisa Miller, Haseeb Mohamed, Tiziana Monteverde, Elizabeth Mouchet, Barbara Nicke, Arnaud Ogier, Anne-Laure Ong, Marc Osterland, Magdalena Otrocka, Pieter J. Peeters, James Pilling, Stefan Prechtl, Chen Qian, Krzysztof Rataj, David E Root, Sylvie K. Sakata, Simon Scrace, Hajime Shimizu, David Simon, Peter Sommer, Craig Spruiell, Iffat Sumia, Susanne E Swalley, Hiroki Terauchi, Amandine Thibaudeau, Amy Unruh, Jelle Van de Waeter, Michiel Van Dyck, Carlo van Staden, Michał Warchoł, Erin Weisbart, Amélie Weiss, Nicolas Wiest-Daessle, Guy Williams, Shan Yu, Bolek Zapiec, Marek Żyła, Shantanu Singh, Anne E. Carpenter

Image-based profiling has emerged as a powerful technology for various steps in basic biological and pharmaceutical discovery, but the community has lacked a large, public reference set of data from chemical and genetic perturbations. Here we present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ad294298f87b0d35776a491fba28d7f
https://doi.org/10.1101/2023.03.23.534023

Agent-Based Modeling of Mitochondria Links Sub-Cellular Dynamics to Cellular Homeostasis and Heterogeneity.

Autor: Giovanni Dalmasso, Paula Andrea Marin Zapata, Nathan Ryan Brady, Anne Hamacher-Brady

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0168198 (2017)

Mitochondria are semi-autonomous organelles that supply energy for cellular biochemistry through oxidative phosphorylation. Within a cell, hundreds of mobile mitochondria undergo fusion and fission events to form a dynamic network. These morphologica

Externí odkaz: https://doaj.org/article/0fc9beca40c34cae88f1b425e6ea5ffc