Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Paula, Moyano"'
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Akademický článek
Thyroid Hormone Neuroprotection Against Perfluorooctane Sulfonic Acid Cholinergic and Glutamatergic Disruption and Neurodegeneration Induction
Autor: Paula Moyano, Gabriela Guzmán, Andrea Flores, Jimena García, Lucia Guerra-Menéndez, Javier Sanjuan, José Carlos Plaza, Luisa Abascal, Olga Mateo, Javier Del Pino
Publikováno v: Biomedicines, Vol 12, Iss 11, p 2441 (2024)
Background: Perfluorooctane sulfonic acid (PFOS), a widely used industrial chemical, was reported to induce memory and learning process dysfunction. Some studies tried to reveal the mechanisms that mediate these effects, but how they are produced is
Externí odkaz: https://doaj.org/article/b3593071cf2942ff96ef4d8ca73f7c70
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2
Akademický článek
Increased Levels of Phosphorylated-P38α Induce WNT/β-Catenin and NGF/P75NTR/TrkA Pathways Disruption and SN56 Cell Death following Single and Repeated Chlorpyrifos Treatment
Autor: Paula Moyano, Andrea Flores, María de la Cabeza Fernández, Jimena García, Javier Sanjuan, José Carlos Plaza, Javier Del Pino
Publikováno v: Foods, Vol 13, Iss 15, p 2427 (2024)
Chlorpyrifos (CPF) biocide, exposure to which is mainly produced in the human population through diet, induces several neurotoxic effects. CPF single and repeated exposure induces memory and learning disorders, although the mechanisms that produce th
Externí odkaz: https://doaj.org/article/fb62872c87244d7893300846c3aeed15
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3
Akademický článek
Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools
Autor: Paula Moyano, Emma Sola, María Victoria Naval, Lucia Guerra-Menéndez, Maria De la Cabeza Fernández, Javier del Pino
Publikováno v: Pharmaceutics, Vol 15, Iss 8, p 2048 (2023)
Environmental pollutants’ (EPs) amount and diversity have increased in recent years due to anthropogenic activity. Several neurodegenerative diseases (NDs) are theorized to be related to EPs, as their incidence has increased in a similar way to hum
Externí odkaz: https://doaj.org/article/9258bda66a33444aba27b492b21b9542
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4
Akademický článek
Bisphenol-A Neurotoxic Effects on Basal Forebrain Cholinergic Neurons In Vitro and In Vivo
Autor: Andrea Flores, Paula Moyano, Emma Sola, José Manuel García, Jimena García, María Teresa Frejo, Lucia Guerra-Menéndez, Elena Labajo, Inés Lobo, Luisa Abascal, Javier del Pino
Publikováno v: Biology, Vol 12, Iss 6, p 782 (2023)
The widely used plasticizer bisphenol-A (BPA) is well-known for producing neurodegeneration and cognitive disorders, following acute and long-term exposure. Although some of the BPA actions involved in these effects have been unraveled, they are stil
Externí odkaz: https://doaj.org/article/21a73fe3b4d84de0b36410f5b1b63499
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5
Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ
Autor: Maria Luisa, Abascal, Javier, Sanjuan, Paula, Moyano, Emma, Sola, Andrea, Flores, José Manuel, Garcia, Jimena, Garcia, María Teresa, Frejo, Javier, Del Pino
Publikováno v: Chemical research in toxicology. 35(12)
Acute and long-term paraquat (PQ) exposure produces hippocampal neurodegeneration and cognition decline. Although some mechanisms involved in these effects were found, the rest are unknown. PQ treatment, for 1 and 14 days, upregulated interferon-gamm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b4630ba3464b1b6589f57b2dee44ff6
https://pubmed.ncbi.nlm.nih.gov/36394833
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7
Aryl Hydrocarbon Receptor Activation Produces Heat Shock Protein 90 and 70 Overexpression, Prostaglandin E2/Wnt/β-Catenin Signaling Disruption, and Cell Proliferation in MCF-7 and MDA-MB-231 Cells after 24 h and 14 Days of Chlorpyrifos Treatment
Autor: Pilar Muñoz-Calero, Adela Pelayo, José Manuel García, Paula Moyano, María Teresa Frejo, A. Flores, Javier del Pino, Jimena García
Publikováno v: Chemical Research in Toxicology. 34:2019-2023
The biocide chlorpyrifos (CPF) was described to increase breast cancer risk in humans, to produce breast cancer in animals, and to induce cell proliferation in MCF-7 and MDA-MB-231 cells after 1 and 14 days of treatment. The entire mechanisms related
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a01db15d4dacded529f54e2bfb63613
https://doi.org/10.1021/acs.chemrestox.1c00258
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8
Neuroprotective mechanisms of multitarget 7-aminophenanthridin-6(5H)-one derivatives against metal-induced amyloid proteins generation and aggregation
Autor: Paula Moyano, David Vicente-Zurdo, Cristina Blázquez-Barbadillo, J. Carlos Menéndez, Juan F. González, Noelia Rosales-Conrado, Javier del Pino
Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
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Brain's metals accumulation is associated with toxic proteins, like amyloid-proteins (Aβ), formation, accumulation, and aggregation, leading to neurodegeneration. Metals downregulate the correct folding, disaggregation, or degradation mechanisms of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdff1b64dc43f713df796e8b497f266
https://eprints.ucm.es/id/eprint/73454/
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