Zobrazeno 1 - 10 of 387 pro vyhledávání: '"Paul. D. Allen"'
1
Akademický článek
Autotransplantation in mdx Mice of mdx Myoblasts Genetically Corrected by an HSV-1 Amplicon Vector
Autor: Mathieu Bujold, Nicolas Caron, Goeffrey Camiran, Santwana Mukherjee, Paul. D. Allen, Jacques P. Tremblay, Yaming Wang M.D.
Publikováno v: Cell Transplantation, Vol 11 (2002)
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder, characterized by a lack of dystrophin. To eliminate the need for immunosuppressive drugs, transplantation of genetically modified autologous myoblasts has been proposed as a possibl
Externí odkaz: https://doaj.org/article/4f314e5ca8bb400e990a8b21a6ce9838
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2
Akademický článek
Post-Anesthesia Cognitive Dysfunction in Mice Is Associated with an Age-Related Increase in Neuronal Intracellular [Ca2+]—Neuroprotective Effect of Reducing Intracellular [Ca2+]: In Vivo and In Vitro Studies
Autor: Arkady Uryash, Alfredo Mijares, Carlos E. Lopez, Jose A. Adams, Paul D. Allen, Jose R. Lopez
Publikováno v: Cells, Vol 13, Iss 3, p 264 (2024)
Background: Postoperative cognitive dysfunction (POCD) is a common disorder after general anesthesia in elderly patients, the precise mechanisms of which remain unclear. Methods: We investigated the effect of isoflurane with or without dantrolene pre
Externí odkaz: https://doaj.org/article/6e74645971b04eeba789094b61b10dd0
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3
Akademický článek
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
Autor: Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R. Lopez, Xiaochen Liu, Christine Diggle, Paul D. Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and tr
Externí odkaz: https://doaj.org/article/afd2999f767e49b494c83b5f5e5c1a4b
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4
Akademický článek
Microbiomics of irrigation with xylitol or Lactococcus lactis in chronic rhinosinusitis
Autor: Paul A. Lambert, Ann L. Gill, Steven R. Gill, Paul D. Allen, Li‐Xing Man
Publikováno v: Laryngoscope Investigative Otolaryngology, Vol 6, Iss 1, Pp 64-70 (2021)
Abstract Objective Topical sinonasal rinse therapies may alter the local microbiome and improve disease control in chronic rhinosinusitis (CRS). The objective of this study was to examine microbiome changes in post‐surgical CRS patients when rinsin
Externí odkaz: https://doaj.org/article/a1ea22384e2a4362a99c2112593e6ea4
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6
Akademický článek
Senescence Is Associated With Elevated Intracellular Resting [Ca2 +] in Mice Skeletal Muscle Fibers. An in vivo Study
Autor: Alfredo Mijares, Paul D. Allen, Jose R. Lopez
Publikováno v: Frontiers in Physiology, Vol 11 (2021)
Aging causes skeletal muscles to become atrophied, weak, and easily fatigued. Here, we have tested the hypothesis that normal aging in skeletal muscle cells is associated with Ca2+ intracellular dyshomeostasis and oxidative stress. Intracellular Ca2+
Externí odkaz: https://doaj.org/article/503072c303874cbba58d14c7c6c92f3b
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7
Akademický článek
Multiple time scales of the ventriloquism aftereffect.
Autor: Adam K Bosen, Justin T Fleming, Paul D Allen, William E O'Neill, Gary D Paige
Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0200930 (2018)
The ventriloquism aftereffect (VAE) refers to a shift in auditory spatial perception following exposure to a spatial disparity between auditory and visual stimuli. The VAE has been previously measured on two distinct time scales. Hundreds or thousand
Externí odkaz: https://doaj.org/article/2240d278f0164500bbea2c83e48c1d69
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