Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Paul-Lennard Mendez"'
Autor:
Vladimir Ugorets, Paul-Lennard Mendez, Dmitrii Zagrebin, Giulia Russo, Yannic Kerkhoff, Georgios Kotsaris, Jerome Jatzlau, Sigmar Stricker, Petra Knaus
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110630- (2024)
Summary: Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells. The transformation of proliferative muscle proge
Externí odkaz:
https://doaj.org/article/e6878bb5d4dc4feca4d91dec25309444
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102859- (2024)
Summary: Chromatin accessibility influences gene regulation and can be quantified using assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq). Recapitulating in vivo fluid shear stress (FSS) mechano-regimes in vitro al
Externí odkaz:
https://doaj.org/article/1058e14ac710475589f453c56254689d
Autor:
Jerome Jatzlau, Paul-Lennard Mendez, Aybuge Altay, Lion Raaz, Yufei Zhang, Sophia Mähr, Akin Sesver, Maria Reichenbach, Stefan Mundlos, Martin Vingron, Petra Knaus
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107405- (2023)
Summary: Bone morphogenetic protein (BMP) signaling and fluid shear stress (FSS) mediate complementary functions in vascular homeostasis and disease development. It remains to be shown whether altered chromatin accessibility downstream of BMP and FSS
Externí odkaz:
https://doaj.org/article/d3aa69edba6440b8ab59fccf51ddb428
Autor:
Paul-Lennard Mendez, Leon Obendorf, Jerome Jatzlau, Wiktor Burdzinski, Maria Reichenbach, Vanasa Nageswaran, Arash Haghikia, Verena Stangl, Christian Hiepen, Petra Knaus
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-receptor Endoglin. While moderate SMAD1/5 activation is required to maintain endothelial quiescence, excessive
Externí odkaz:
https://doaj.org/article/f21e33dc96904caabcbae15c6de679ca
Publikováno v:
Cells, Vol 9, Iss 9, p 1965 (2020)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGFβ) superfamily of cytokines. While some ligand members are potent inducers of angiogenesis, others promote vascular homeostasis. However, the precise understan
Externí odkaz:
https://doaj.org/article/025d67e5f68a40d9b5a84c5417ffe66f
Publikováno v:
Journal of visualized experiments : JoVE. (175)
Transforming Growth Factor β (TGFβ)/Bone Morphogenetic Protein (BMP) signaling is tightly regulated and balanced during the development and homeostasis of the vasculature system Therefore, deregulation in this signaling pathway results in severe va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f83214f111b7fe66da75b6f4d68a72b
https://pubmed.ncbi.nlm.nih.gov/34605801
https://pubmed.ncbi.nlm.nih.gov/34605801
Publikováno v:
Journal of Visualized Experiments.
Transforming Growth Factor β (TGFβ)/Bone Morphogenetic Protein (BMP) signaling is tightly regulated and balanced during the development and homeostasis of the vasculature system Therefore, deregulation in this signaling pathway results in severe va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613016a67dd6e2ea40044a63306f1f7d
https://doi.org/10.3791/62608-v
https://doi.org/10.3791/62608-v