Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Paul Zeun"'
Autor:
Yara Refaat Hassan, Filipe Brogueira Rodrigues, Paul Zeun, Lauren M. Byrne, Carlos Estevez-Fraga, Rosanna Tortelli, Rachael I. Scahill, Edward J. Wild, Sarah J. Tabrizi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Lumbar puncture (LP) has become increasingly common for people with Huntington’s disease (HD) both to administer intrathecal investigational medicinal products and to collect cerebrospinal fluid to develop biological markers to track disea
Externí odkaz:
https://doaj.org/article/ad4a5e730417443781456cf2e0327ad6
Autor:
Paul Zeun, Peter McColgan, Thijs Dhollander, Sarah Gregory, Eileanoir B. Johnson, Marina Papoutsi, Akshay Nair, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi
Publikováno v:
NeuroImage: Clinical, Vol 33, Iss , Pp 102927- (2022)
Objectives: To investigate the timeframe prior to symptom onset when cortico-basal ganglia white matter (white matter) loss begins in premanifest Huntington’s disease (preHD), and which striatal and thalamic sub-region white matter tracts are most
Externí odkaz:
https://doaj.org/article/fd0c448432f7454cb40720aa895efbbd
Autor:
Eileanoir B. Johnson, Christopher S. Parker, Rachael I. Scahill, Sarah Gregory, Marina Papoutsi, Paul Zeun, Katherine Osborne-Crowley, Jessica Lowe, Akshay Nair, Carlos Estevez-Fraga, Kate Fayer, Geraint Rees, Hui Zhang, Sarah J. Tabrizi
Publikováno v:
EBioMedicine, Vol 65, Iss , Pp 103266- (2021)
Background: Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was evi
Externí odkaz:
https://doaj.org/article/a5b119aef0874e58add8c97f8d4a0310
Autor:
Robb B. Rutledge, Sarah J. Tabrizi, Marina Papoutsi, Jessica Lowe, Paul Zeun, Sarah Gregory, Geraint Rees, Akshay Nair, Stefano Palminteri, Eileanoir B. Johnson, Katherine Osborne-Crowley, Rachael I. Scahill
Publikováno v:
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Background In this study, we asked whether differences in striatal activity during a reinforcement learning (RL) task with gain and loss domains could be one of the earliest functional imaging features associated with carrying the Huntington's diseas
Autor:
Christelle Langley, Sarah Gregory, Katherine Osborne-Crowley, Claire O’Callaghan, Paul Zeun, Jessica Lowe, Eileanoir Johnson, Marina Papoutsi, Rachael Scahill, Geraint Rees, Sarah Tabrizi, Trevor Robbins, Barbara Sahakian
Publikováno v:
E: Imaging.
Autor:
Filipe B. Rodrigues, Eileanoir B. Johnson, Cristina Sampaio, Harpreet Hyare, Geraint Rees, Rachael I. Scahill, Jessica M. Lowe, Kate Fayer, Paul Zeun, Trevor W. Robbins, Akshay Nair, Marina Papoutsi, Barbara J. Sahakian, Henrik Zetterberg, Henny Wellington, Amanda Heslegrave, Edward J. Wild, Peter McColgan, Katherine Osborne-Crowley, Christelle Langley, Douglas R. Langbehn, Hui Zhang, Lauren M. Byrne, Sarah Gregory, Carlos Estevez Fraga, Christopher S. Parker, Claire O'Callaghan, Sarah J. Tabrizi
Publikováno v:
F: Clinical studies: case reports, observational studies and trials.
Autor:
Peter McColgan, Sarah Gregory, Paul Zeun, Angeliki Zarkali, Eileanoir B Johnson, Christopher Parker, Kate Fayer, Jessica Lowe, Akshay Nair, Carlos Estevez-Fraga, Marina Papoutsi, Hui Zhang, Rachael I Scahill, Sarah J Tabrizi, Geraint Rees
Publikováno v:
Brain
Upregulation of functional network connectivity in the presence of structural degeneration is seen in the premanifest stages of Huntington’s disease (preHD) 10–15 years from clinical diagnosis. However, whether widespread network connectivity cha
Publikováno v:
Molecular and Cellular Neuroscience. 97:67-80
Huntington's disease is a chronic progressive neurodegenerative condition for which there is no disease-modifying treatment. The known genetic cause of Huntington's disease makes it possible to identify individuals destined to develop the disease and
Autor:
Sarah Gregory, Jessica Lowe, Marina Papoutsi, Eileanoir B. Johnson, Rachael I. Scahill, Katherine Osborne-Crowley, Hui Zhang, Carlos Estevez-Fraga, Geraint Rees, Kate Fayer, Paul Zeun, Akshay Nair, Christopher S. Parker, Sarah J. Tabrizi
Publikováno v:
EBioMedicine
EBioMedicine, Vol 65, Iss, Pp 103266-(2021)
EBioMedicine, Vol 65, Iss, Pp 103266-(2021)
Background Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff4870fed0a5a7173ed1bec0ec2a0ab
https://hdl.handle.net/21.11116/0000-0008-53EA-3
https://hdl.handle.net/21.11116/0000-0008-53EA-3
Autor:
Jessica Lowe, Sarah Gregory, Paul Zeun, Eileanoir B. Johnson, Trevor W. Robbins, Claire O'Callaghan, Barbara J. Sahakian, Rachael I. Scahill, Marina Papoutsi, Geraint Rees, Christelle Langley, Katie Osborne-Crowley, Sarah J. Tabrizi
Publikováno v:
Journal of Neurology, Neurosurgery, and Psychiatry
ObjectivesCognitive flexibility, which is key for adaptive decision-making, engages prefrontal cortex (PFC)-striatal circuitry and is impaired in both manifest and premanifest Huntington’s disease (pre-HD). The aim of this study was to examine cogn