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Akademický článek

LINC00116-encoded microprotein mitoregulin regulates fatty acid metabolism at the mitochondrial outer membrane

Autor: Shan Zhang, Yabo Guo, Gio Fidelito, David R.L. Robinson, Chao Liang, Radiance Lim, Zoë Bichler, Ruiyang Guo, Gaoqi Wu, He Xu, Quan D. Zhou, Brijesh K. Singh, Paul Yen, Dennis Kappei, David A. Stroud, Lena Ho

Publikováno v: iScience, Vol 26, Iss 9, Pp 107558- (2023)

Summary: LINC00116 encodes a microprotein first identified as Mitoregulin (MTLN), where it was reported to localize to the inner membrane of mitochondria to regulate fatty acid oxidation and oxidative phosphorylation. These initial discoveries were f

Externí odkaz: https://doaj.org/article/b76d12dc105f40af9b3523b6c63545e2

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Akademický článek

Lipidomics Workflow for Analyzing Lipid Profiles Using Multiple Reaction Monitoring (MRM) in Liver Homogenate of Mice with Non-alcoholic Steatohepatitis (NASH)

Autor: Hai Ning Wee, Lye Siang Lee, Sharon Han, Jin Zhou, Paul Yen, Jianhong Ching

Publikováno v: Bio-Protocol, Vol 13, Iss 13 (2023)

Non-alcoholic steatohepatitis (NASH) is a condition characterized by inflammation and hepatic injury/fibrosis caused by the accumulation of ectopic fats in the liver. Recent advances in lipidomics have allowed the identification and characterization

Externí odkaz: https://doaj.org/article/b222d70c69b84f23b3c7ca40c8f2f99a

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Noise in the operating room during induction of anesthesia: impact of a quality improvement initiative

Autor: Charles V. Yu, Julena Foglia, Paul Yen, Trina Montemurro, Stephan K. W. Schwarz, Su-Yin MacDonell

Publikováno v: Canadian journal of anaesthesia = Journal canadien d'anesthesie. 69(4)

Noise in the operating room (OR) is common and associated with negative effects on anesthesiologists, surgeons, and patient outcomes. Induction of anesthesia is among the loudest perioperative periods. Despite its critical nature, there is little dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ccb248b870c8e8dd946b7dd38e2be8
https://pubmed.ncbi.nlm.nih.gov/35182358

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Akademický článek

An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 8, Pp 294-310 (2020)

Using a mini-library of 1062 lentiviral shRNAs targeting 40 nuclear hormone receptors and 70 of their co-regulators, we searched for potential therapeutic targets that would be important during in vivo tumor growth using a parallel in vitro and in vi

Externí odkaz: https://doaj.org/article/482fd373bde3424183dc0e497a6a3920

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Akademický článek

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors

Publikováno v: Cell Reports, Vol 19, Iss 8, Pp 1669-1684 (2017)

Although non-small cell lung cancer (NSCLC) patients benefit from standard taxane-platin chemotherapy, many relapse, developing drug resistance. We established preclinical taxane-platin-chemoresistance models and identified a 35-gene resistance signa

Externí odkaz: https://doaj.org/article/b799525f4c5f4794b566dfe7987f5ae9

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