Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Paul Yazaki"'
Autor:
Min Guan, Laura Lim, Leo Holguin, Tianxu Han, Vibhuti Vyas, Ryan Urak, Aaron Miller, Diana L. Browning, Liliana Echavarria, Shasha Li, Shirley Li, Wen-Chung Chang, Tristan Scott, Paul Yazaki, Kevin V. Morris, Angelo A. Cardoso, M. Suzette Blanchard, Virginia Le Verche, Stephen J. Forman, John A. Zaia, John C. Burnett, Xiuli Wang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 344-359 (2022)
T cells engineered to express HIV-specific chimeric antigen receptors (CARs) represent a promising strategy to clear HIV-infected cells, but to date have not achieved clinical benefits. A likely hurdle is the limited T cell activation and persistence
Externí odkaz:
https://doaj.org/article/c35d7761f02247f9aa1379d906dc6325
Publikováno v:
Cancer Medicine, Vol 9, Iss 13, Pp 4756-4767 (2020)
Abstract Introduction Ovarian cancer has only a 17% 5‐year survival rate in patients diagnosed with late stage disease. Tumor‐associated glycoprotein‐72 (TAG72), expressed in 88% of all stages of ovarian cancer, is an excellent candidate for an
Externí odkaz:
https://doaj.org/article/39c08780ebd94cffa6cfb8035f48bfb8
Autor:
Maciej Kujawski, Lin Li, Supriyo Bhattacharya, Patty Wong, Wen-Hui Lee, Lindsay Williams, Harry Li, Junie Chea, Kofi Poku, Nicole Bowles, Nagarajan Vaidehi, Paul Yazaki, John E. Shively
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Bispecific T-cell engaging antibodies (BiTES), comprising dual anti-CD3 and anti-tumor antigen scFv fragments, are important therapeutic agents for the treatment of cancer. The dual scFv construct for BiTES requires proper protein
Externí odkaz:
https://doaj.org/article/ac867d27e03b48d49a75f75d86b0177f
Autor:
Hannah M Hollandsworth, Siamak Amirfakhri, Filemoni Filemoni, Justin Molnar, Robert M Hoffman, Paul Yazaki, Michael Bouvet
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234643 (2020)
BackgroundPhotoimmunotherapy (PIT) employs the use of a near-infrared (NIR) laser to activate an antibody conjugated to a NIR-activatable dye to induce cancer cell death. PIT has shown to be effective in a number of studies, however, there are no dat
Externí odkaz:
https://doaj.org/article/bb1dafcb03d84340aaf055d869bdf4df
Autor:
Maciej Kujawski, Mark Sherman, Susanta Hui, Darren Zuro, Wen-Hui Lee, Paul Yazaki, Anakim Sherman, Barbara Szpikowska, Junie Chea, Desiree Lasiewski, Kofi Poku, Harry Li, David Colcher, Jeffrey Wong, John E. Shively
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
While anti-CEA antibodies have no direct effect on CEA-positive tumors, they can be used to direct potent anti-tumor effects as an antibody-IL-2 fusion protein (immunocytokine, ICK), and at the same time reduce the toxicity of IL-2 as a single agent.
Externí odkaz:
https://doaj.org/article/8d687e3850454660b664629f00e35ad7
Autor:
John P. Murad, Anna K. Kozlowska, Hee Jun Lee, Maya Ramamurthy, Wen-Chung Chang, Paul Yazaki, David Colcher, John Shively, Mihaela Cristea, Stephen J. Forman, Saul J. Priceman
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Impressive clinical efficacy of chimeric antigen receptor (CAR)-engineered T cell therapy for hematological malignancies have prompted significant efforts in achieving similar responses in solid tumors. The lack of truly restricted and uniform expres
Externí odkaz:
https://doaj.org/article/03ff7a9430ab4c70be8c4bbe6027d5ef
Publikováno v:
E-Posters.
Autor:
Min Guan, Laura Lim, Leo Holguin, Tianxu Han, Vibhuti Vyas, Ryan Urak, Aaron Miller, Diana L. Browning, Liliana Echavarria, Shasha Li, Shirley Li, Wen-Chung Chang, Tristan Scott, Paul Yazaki, Kevin V. Morris, Angelo A. Cardoso, M. Suzette Blanchard, Virginia Le Verche, Stephen J. Forman, John A. Zaia, John C. Burnett, Xiuli Wang
Publikováno v:
Molecular therapy. Methodsclinical development. 25
T cells engineered to express HIV-specific chimeric antigen receptors (CARs) represent a promising strategy to clear HIV-infected cells, but to date have not achieved clinical benefits. A likely hurdle is the limited T cell activation and persistence
Autor:
Achim, Rothe, Ron D, Jachimowicz, Sven, Borchmann, Marie, Madlener, Jörg, Keßler, Katrin S, Reiners, Maike, Sauer, Hinrich P, Hansen, Roland T, Ullrich, Sampurna, Chatterjee, Peter, Borchmann, Paul, Yazaki, Thomas C, Koslowsky, Andreas, Engert, Lukas C, Heukamp, Michael, Hallek, Elke Pogge, von Strandmann
Publikováno v:
International journal of cancer. 134(12)
NKG2D, an activating receptor expressed on NK cells and T cells, is critically involved in tumor immunosurveillance. In this study, we explored the potential therapeutic utility of the NKG2D ligand ULBP2 for the treatment of colon carcinoma. To this
Autor:
Jeffrey Y.C. Wong, Andrew Raubitschek, Dave Yamauchi, Lawrence E. Williams, Anna M. Wu, Paul Yazaki, John E. Shively, David Colcher, George Somlo
Publikováno v:
Cancer Biotherapy & Radiopharmaceuticals; Aug2010, Vol. 25 Issue 4, p387-394, 8p