Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Paul W.M. Fedak, MD, PhD"'
Autor:
Ali Fatehi Hassanabad, MD, MSc, Friederike I. Schoettler, MD, William D.T. Kent, MD, MSc, Corey A. Adams, MD, MSc, Daniel D. Holloway, MD, MSc, Imtiaz S. Ali, MD, Richard J. Novick, MD, MSc, Muhammad R. Ahsan, MBBS, Robert Scott McClure, MD, MSc, Ganesh Shanmugam, MD, William T. Kidd, MD, Teresa M. Kieser, MD, PhD, Paul W.M. Fedak, MD, PhD, Justin F. Deniset, PhD
Publikováno v:
JTCVS Open, Vol 16, Iss , Pp 389-400 (2023)
Objectives: Cardiac surgery using cardiopulmonary bypass contributes to a robust systemic inflammatory process. Local intrapericardial postsurgical inflammation is believed to trigger important clinical implications, such as postoperative atrial fibr
Externí odkaz:
https://doaj.org/article/77fb7a8e72644a0fb844c0a7ac7a2e72
Autor:
Ali Fatehi Hassanabad, MD, MSc, Friederike I. Schoettler, MD, William D.T. Kent, MD, MSc, Corey A. Adams, MD, MSc, Daniel D. Holloway, MD, MSc, Imtiaz S. Ali, MD, Richard J. Novick, MD, MSc, Muhammad R. Ahsan, MBBS, Robert Scott McClure, MD, MSc, Ganesh Shanmugam, MD, William T. Kidd, MD, Teresa M. Kieser, MD, PhD, Paul W.M. Fedak, MD, PhD, Justin F. Deniset, PhD
Publikováno v:
JTCVS Open, Vol 12, Iss , Pp 118-136 (2022)
Objective: There is a paucity of data on the inflammatory response that takes place in the pericardial space after cardiac surgery. This study provides a comprehensive assessment of the local postoperative inflammatory response. Methods: Forty-three
Externí odkaz:
https://doaj.org/article/104f69dfe5ae4b8cb7ab78cb2efbf00e
Autor:
Miriam Nightingale, MASc, Alexander Gregory, MD, Taisiya Sigaeva, PhD, Gary M. Dobson, MDCM, MSc, DIC, Paul W.M. Fedak, MD, PhD, Jehangir J. Appoo, MD, Elena S. Di Martino, PhD, Richard Beddoes, MSc, Alicia Nickel, MD, Samaneh Sattari, MSc, Amy Bromley, MD
Publikováno v:
JTCVS Open, Vol 9, Iss , Pp 1-10 (2022)
Objective: This study correlates low strain tangential modulus (LTM) and transition zone onset (TZo) stress, biomechanical parameters that occur within the physiological range of stress seen in vivo, with tissue strength and histopathologic changes i
Externí odkaz:
https://doaj.org/article/45327bfee86e43d09ea0b78d8eea3224
Publikováno v:
JTCVS Open, Vol 8, Iss , Pp 173-174 (2021)
Externí odkaz:
https://doaj.org/article/daeb1bcfb99f4cbaa36a344b54606a5d
Publikováno v:
JTCVS Open, Vol 7, Iss , Pp 45-46 (2021)
Externí odkaz:
https://doaj.org/article/3be127e141b540e0bc19afbd812bac5f
Autor:
Nikole J. Byrne, BSc, Nirmal Parajuli, PhD, Jody L. Levasseur, BSc, Jamie Boisvenue, BTech, Donna L. Beker, Grant Masson, BSc, Paul W.M. Fedak, MD, PhD, Subodh Verma, MD, PhD, Jason R.B. Dyck, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 4, Pp 347-354 (2017)
This study sought to determine whether the sodium/glucose cotransporter 2 (SGLT2) inhibitor empagliflozin improved heart failure (HF) outcomes in nondiabetic mice. The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in Type 2 Diab
Externí odkaz:
https://doaj.org/article/b8f761721afe4ce8a10d25385c71df66
Autor:
Holly E.M. Mewhort, MD, PhD, Daniyil A. Svystonyuk, BSc, Jeannine D. Turnbull, BSc, Guoqi Teng, PhD, Darrell D. Belke, PhD, David G. Guzzardi, BSc, Daniel S. Park, BSc, Sean Kang, BSc, Morley D. Hollenberg, MD, PhD, Paul W.M. Fedak, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 4, Pp 450-464 (2017)
Structural cardiac remodeling after ischemic injury can induce a transition to heart failure from progressive loss of cardiac function. Cellular regenerative therapies are promising but face significant translational hurdles. Tissue extracellular mat
Externí odkaz:
https://doaj.org/article/cf90dedf8ce14b09a6a5fae040d08d80