Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Paul W. Whitby"'
Publikováno v:
Vaccine. 38:2960-2970
Nontypeable strains of Haemophilus influenzae (NTHi) are one of the most common cause of otitis media and the most frequent infection associated with exacerbations of chronic obstructive pulmonary disease; there is currently no vaccine in the U.S. to
Autor:
Zachary N Phillips, Amy V Jennison, Paul W Whitby, Terrence L Stull, Megan Staples, John M Atack
Publikováno v:
FEMS Microbiology Letters. 369
Non-typeable Haemophilus influenzae (NTHi) is a major human pathogen for which there is no globally licensed vaccine. NTHi has a strict growth requirement for iron and encodes several systems to scavenge elemental iron and heme from the host. An effe
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136867 (2015)
Nontypeable Haemophilus influenzae (NTHi) cause significant disease, including otitis media in children, exacerbations of chronic obstructive pulmonary disease, and invasive disease in susceptible populations. No vaccine is currently available to pre
Externí odkaz:
https://doaj.org/article/9a2cdcd40adc49518730357c039c76ec
Autor:
Paul W Whitby, Daniel J Morton, Timothy M Vanwagoner, Thomas W Seale, Brett K Cole, Huda J Mussa, Phillip A McGhee, Chee Yoon S Bauer, Jennifer M Springer, Terrence L Stull
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50588 (2012)
To prevent damage by reactive oxygen species, many bacteria have evolved rapid detection and response systems, including the OxyR regulon. The OxyR system detects reactive oxygen and coordinates the expression of numerous defensive antioxidants. In m
Externí odkaz:
https://doaj.org/article/fc110bf57e3045809b02dceec5e39e3e
Autor:
Dharambir K. Sanghera, Cynthia Bejar, Megan Malone-Perez, Chinthapally V. Rao, Ruth Hopkins, Stan Lightfoot, Huda Mussa, J. Kimble Frazer, Paul W. Whitby, Chengcheng Tan, Kar Ming Fung
Dyslipidemia is a well-established risk factor for cardiovascular diseases. Although, advances in genome-wide technologies have enabled the discovery of hundreds of genes associated with blood lipid phenotypes, most of the heritability remains unexpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebad97d3f616728bef70d4079de25dde
https://doi.org/10.1101/526350
https://doi.org/10.1101/526350
Publikováno v:
Open Forum Infectious Diseases
Background The H. influenzae type b vaccines target the type b capsule and therefore have no impact on the nontypable (unencapsulated) H. influenzae (NTHi). NTHi has become the most common cause of otitis media and is the most common isolate from pat
Autor:
Megan Malone-Perez, Dharambir K. Sanghera, Huda Mussa, Ruth Hopkins, Cynthia Bejar, Stan Lightfoot, J. Kimble Frazer, Ben Fowler, Paul W. Whitby, Chengcheng Tan, Chinthapally V. Rao, Kar Ming Fung
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0211661 (2019)
PLoS ONE
PLoS ONE
Dyslipidemia is a well-established risk factor for cardiovascular diseases. Although, advances in genome-wide technologies have enabled the discovery of hundreds of genes associated with blood lipid phenotypes, most of the heritability remains unexpl
Autor:
Elizabeth S. Didier, Miguel Coelho, Iain Ridgway, Tracy T. Chow, Paul W. Whitby, Insil Kim, Eva E. R. Philipp, Philip McQuary, William E. Sonntag, Courtney M. Campbell, Sara Gelino, Zoltan Ungvari, Marissa A. Holmbeck, Danuta Sosnowska, Anna Csiszar, Steven N. Austad, Erik Levy
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 68:359-367
Bivalve species with exceptional longevity are newly introduced model systems in biogerontology to test evolutionarily conserved mechanisms of aging. Here, we tested predictions based on the oxidative stress hypothesis of aging using one of the tropi
Autor:
Daniel J. Morton, Terrence L. Stull, Timothy M. VanWagoner, Thomas W. Seale, Huda J. Mussa, Paul W. Whitby
Publikováno v:
Genome Announcements
Nontypeable Haemophilus influenzae is an important cause of human disease. Strains were selected for genome sequencing to represent the breadth of nontypeable strains within the species, as previously defined by the electrophoretic mobility of 16 met
Autor:
Lauren O. Bakaletz, Daniel J. Morton, Terrence L. Stull, Thomas W. Seale, Timothy M. VanWagoner, Ann Smith, Paul W. Whitby, Joseph A. Jurcisek
Publikováno v:
International Journal of Medical Microbiology. 299:479-488
Haemophilus influenzae has an absolute growth requirement for heme and the heme-binding lipoprotein (HbpA) and has been implicated in the utilization of this essential nutrient. We constructed an insertional mutation of hbpA in a type b and a nontype