Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Paul W. Smith"'
Autor:
Paul W. Smith
Publikováno v:
CHIMIA, Vol 53, Iss 6 (1999)
Externí odkaz:
https://doaj.org/article/b551aac542634b66a89737bd2702c039
Autor:
Ujjini H. Manjunatha, Christel Brunschwig, Mathew Njoroge, Srinivasa P. S. Rao, Nina Lawrence, Dale Taylor, Rudolf Müller, Kelly Chibale, Paul M. Njaria, Renier van der Westhuyzen, Vinayak Singh, Leslie J. Street, Amanda Mabhula, Atica Moosa, Digby F. Warner, Denis Ngumbu Muhunga, Paul W. Smith
Publikováno v:
Journal of Medicinal Chemistry. 64:9444-9457
Screening of a library of small polar molecules against Mycobacterium tuberculosis (Mtb) led to the identification of a potent benzoheterocyclic oxime carbamate hit series. This series was subjected to medicinal chemistry progression underpinned by s
Autor:
Dana Meaney-Delman, Yon Yu, Cheryl S. Broussard, Emmy L Tran, Hye-Joo Kim, Christina A. Nelson, Patricia A. Yu, Eileen L. Yee, Corinne M Parker, Paul W Smith, Zachary Russell
Publikováno v:
Clinical Infectious Diseases. 70:S37-S50
BackgroundThe safety profile of antimicrobials used during pregnancy is one important consideration in the decision on how to treat and provide postexposure prophylaxis (PEP) for plague during pregnancy.MethodsWe searched 5 scientific literature data
Autor:
Renier, van der Westhuyzen, Amanda, Mabhula, Paul M, Njaria, Rudolf, Müller, Denis, Ngumbu Muhunga, Dale, Taylor, Nina, Lawrence, Mathew, Njoroge, Christel, Brunschwig, Atica, Moosa, Vinayak, Singh, Srinivasa P S, Rao, Ujjini H, Manjunatha, Paul W, Smith, Digby F, Warner, Leslie J, Street, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(13)
Screening of a library of small polar molecules against
Autor:
Pei Yong Shi, Fumiaki Yokokawa, Rishi Arora, Cheah Chen Seh, Timothy E. Benson, Siew Pheng Lim, Paul W. Smith, Shahul Nilar, S. Kirk Wright, Christian G. Noble
Publikováno v:
Journal of Biological Chemistry. 291:8541-8548
We performed a fragment screen on the dengue virus serotype 3 RNA-dependent RNA polymerase using x-ray crystallography. A screen of 1,400 fragments in pools of eight identified a single hit that bound in a novel pocket in the protein. This pocket is
Autor:
Luis R. Camacho, Srinivasa P. S. Rao, Christian G. Noble, Ravinder Reddy Kondreddi, Thierry T. Diagana, Ujjini H. Manjunatha, Anne Goh, Maxime Herve, Paul W. Smith, Stefan Peukert, Pearly Shuyi Ng, Ngai Ling Ma
Publikováno v:
European Journal of Medicinal Chemistry. 106:144-156
Pyridone 1 was identified from a high-throughput cell-based phenotypic screen against Mycobacterium tuberculosis (Mtb) including multi-drug resistant tuberculosis (MDR-TB) as a novel anti-TB agent and subsequently optimized series using cell-based Mt
Autor:
Paul W, Smith, Fabio, Zuccotto, Robert H, Bates, Maria Santos, Martinez-Martinez, Kevin D, Read, Caroline, Peet, Ola, Epemolu
Publikováno v:
ACS Infectious Diseases
β-Lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research, none of the currently approved drugs in this class combine oral activity with long duration of action. Recent develop
Autor:
Julien Lescar, Feng Gu, Kah Fei Wan, Francesca Blasco, CongBao Kang, Wai Ling Chan, Wei Liu, Paul W. Smith, Agatha Susila, Bin Zou, Qing Yin Wang, K.L. Yeo, Mei Ding, Chao Shan, Andy M. Yip, Haoying Xu, Hongping Dong, Jing Zou, Suresh B. Lakshminarayana, Ratna Karuna, Pei Yong Shi, Peck Gee Seah
Publikováno v:
Journal of Virology. 89:8233-8244
The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone compound that
Autor:
Hao Ying Xu, Wei Liu, Feng Gu, Bin Zou, Wai Ling Chan, Paul W. Smith, Kah Fei Wan, Ratna Karuna, Agatha Susila, Peck Gee Seah, Andy Yip, Pei Yong Shi, Trixie Wagner, Thierry T. Diagana, Qing Yin Wang, Alex Chao, Mei Ding, Hongping Dong, Seh Yong Leong, Francesca Blasco, Katherine Chan, Shahul Nilar, Ina Dix
Publikováno v:
ACS Medicinal Chemistry Letters. 6:344-348
Spiropyrazolopyridone 1 was identified, as a novel dengue virus (DENV) inhibitor, from a DENV serotype 2 (DENV-2) high-throughput phenotypic screen. As a general trend within this chemical class, chiral resolution of the racemate revealed that R enan
Publikováno v:
Chinese Journal of Chemistry. 32:1217-1220
A mild and efficient synthesis of spiroquinoxalinones via tandem condensation of chlorooxoindoline 1 with benzene-1,2-diamines 2 is described. And a plausible mechanism for the reaction is proposed.