Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Paul W. Lenkowski"'
Publikováno v:
Pfl�gers Archiv - European Journal of Physiology. 449:403-412
Cardiac sodium channels (Nav1.5) comprise a pore-forming α-subunit and auxiliary β-subunits that modulate channel function. In the heart, β1 is expressed throughout the atria and ventricles, whilst β3 is present only in the ventricles and Purkinj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::178a0c29cf14c1688f9d6211ebcd1831
https://doi.org/10.1007/s00424-004-1348-4
https://doi.org/10.1007/s00424-004-1348-4
Autor:
William A. Petri, Aleida Eubanks, David M. Lyerly, Lauren A. Lockhart, James M. Dodson, Jason Napodano, Paul W. Lenkowski, Terry F. G. H. Jackson, Barbara J. Mann
Publikováno v:
The Journal of Infectious Diseases. 179:460-466
Entamoeba histolytica causes invasive amebiasis, a major parasitic disease of the developing world, whose primary symptoms are liver abscess and colitis. All strains of E. histolytica express a 260-kDa surface Gal/GalNAc lectin that is antigenically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c54cf82a02a6c6bab4f2f658896d34
https://doi.org/10.1086/314610
https://doi.org/10.1086/314610
We describe the clinical evaluation and operative management of posterior semicircular canal dehiscence caused by a high jugular bulb.We performed a retrospective case report.The patient had clinical and audiometric findings consistent with semicircu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d16fe9532d1c4aed1c7d9e85ba685e
https://europepmc.org/articles/PMC3972486/
https://europepmc.org/articles/PMC3972486/
Autor:
Paul W. Lenkowski, Nina Jochnowitz, Milton L. Brown, William J. Martin, Seong-Hoon Ko, Gary C. Davis, Manoj K. Patel, Timothy W. Batts
Publikováno v:
Neuropharmacology. 50(7)
Sodium (Na) channel blockers are known to possess antihyperalgesic properties. We have designed and synthesized a novel Na channel antagonist, alpha-hydroxyphenylamide, and determined its ability to inhibit both TTX-sensitive (TTX-s) and TTX-resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c06441e0ce2d389a0c8ba72bdef5eeb
https://pubmed.ncbi.nlm.nih.gov/16464480
https://pubmed.ncbi.nlm.nih.gov/16464480
Autor:
Manoj K. Patel, Antony P. Jackson, Seong-Hoon Ko, Paul W. Lenkowski, Esther J. Yu, Alena Pance
Publikováno v:
The Biochemical journal. 392(Pt 3)
Electrical excitability in neurons depends on the expression and activity of voltage-gated sodium channels in the neuronal plasma membrane. The ion-conducting alpha-subunit of the channel is associated with auxiliary beta-subunits of which there are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f500b25883ca3f4684c4f4a6ffe1e118
https://pubmed.ncbi.nlm.nih.gov/16080781
https://pubmed.ncbi.nlm.nih.gov/16080781
Publikováno v:
Pflugers Archiv : European journal of physiology. 449(4)
Cardiac sodium channels (Na(v)1.5) comprise a pore-forming alpha-subunit and auxiliary beta-subunits that modulate channel function. In the heart, beta1 is expressed throughout the atria and ventricles, whilst beta3 is present only in the ventricles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee7bd38dd3f6ab4d7b9bab9c146cb39c
https://pubmed.ncbi.nlm.nih.gov/15455233
https://pubmed.ncbi.nlm.nih.gov/15455233
Autor:
James D, Anderson, Todd P, Hansen, Paul W, Lenkowski, Alison M, Walls, Indrani M, Choudhury, Hilary A, Schenck, Mati, Friehling, Genevieve M, Höll, Manoj K, Patel, Robert A, Sikes, Milton L, Brown
Publikováno v:
Molecular cancer therapeutics. 2(11)
The recent discovery of sodium (Na(+)) channel expression in human prostate cancer (PCa) cells led us to investigate the potential use of neuronal Na(+) channel blockers as inhibitors of PCa cells. Our initial studies discovered two classes of Na(+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::166c95f10d8339ddbbe4fe118679c1f4
https://pubmed.ncbi.nlm.nih.gov/14617788
https://pubmed.ncbi.nlm.nih.gov/14617788
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 21(5)
Voltage-gated sodium (Na) channels are a critical component of electrically excitable cells. Phenytoin (diphenylhydantoin, DPH) is an established sodium channel blocker and is a useful anticonvulsant and class 1b antiarrhythmic, and has been effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d733475b64c0f1d3c1653c3622e083c
https://pubmed.ncbi.nlm.nih.gov/15066664
https://pubmed.ncbi.nlm.nih.gov/15066664
Autor:
Indrani Choudhury-Mukherjee, James P. Stables, Milton L. Brown, Paul W. Lenkowski, Hilary A. Schenck, Seong-Hoon Ko, Manoj K. Patel
Publikováno v:
Bioorganicmedicinal chemistry. 12(5)
Themisone, also known as Atrolactamide, was found, in the 1950s, to be a very potent anticonvulsant. It was hypothesized that the -CF3 substitution would maintain the anticonvulsant activity. Anticonvulsant testing of our novel compounds by the Natio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4243b3c5978a5d89ec9d1a8aa9a0c4c4
https://pubmed.ncbi.nlm.nih.gov/14980611
https://pubmed.ncbi.nlm.nih.gov/14980611
Publikováno v:
European journal of pharmacology. 467(1-3)
The effects of lidocaine on neonatal Na(v)1.3 (Na(v)1.3n) expressed alone and in combination with beta1 and beta3 subunits in Xenopus oocytes were examined. Lidocaine reversibly inhibited the peak Na(v)1.3n current, shifted the steady-state inactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358a61d9dbd54712933fb7ef733773fe
https://pubmed.ncbi.nlm.nih.gov/12706451
https://pubmed.ncbi.nlm.nih.gov/12706451