Výsledky vyhledávání - "Paul W. Keller"

Akademický článek

Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it.

Autor: Wei Wang, Russell Vassell, Hyo Sook Song, Qiong Chen, Paul W Keller, Swati Verma, Esmeralda Alvarado-Facundo, Hongquan Wan, Falko Schmeisser, Clement A Meseda, Jerry P Weir, Carol D Weiss

Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0222436 (2019)

Vaccines that elicit broadly cross-neutralizing antibodies, including antibodies that target the conserved stem of hemagglutinin (HA), are being developed as a strategy for next-generation influenza vaccines that protect against influenza across mult

Externí odkaz: https://doaj.org/article/7179238de9d04527910581e425d8b71f

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Mutations That Increase the Stability of the Postfusion gp41 Conformation of the HIV-1 Envelope Glycoprotein Are Selected by both an X4 and R5 HIV-1 Virus To Escape Fusion Inhibitors Corresponding to Heptad Repeat 1 of gp41, but the gp120 Adaptive Mutations Differ between the Two Viruses

Autor: Russell Vassell, Chen Yuan, Paul W. Keller, Carol D. Weiss, Wei Wang, Min Zhuang, Hong Ling

Publikováno v: Journal of Virology. 93

Binding of the gp120 surface subunit of the envelope glycoprotein (Env) of HIV-1 to CD4 and chemokine receptors on target cells triggers refolding of the gp41 transmembrane subunit into a six-helix bundle (6HB) that promotes fusion between virus and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57de2c4d3c2642f0b4fbbf0065437cb
https://doi.org/10.1128/jvi.00142-19

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HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120

Autor: Paul W. Keller, Orrianne Morrison, Russell Vassell, Carol D. Weiss

Publikováno v: Journal of Virology. 92

Entry of human immunodeficiency virus type 1 (HIV-1) into host cells is mediated by conformational changes in the envelope glycoprotein (Env) that are triggered by Env binding to cellular CD4 and chemokine receptors. These conformational changes invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eca46ef1483ce3237a4e0e996979c5
https://doi.org/10.1128/jvi.00583-18

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Conformational Stability of the Hemagglutinin of H5N1 Influenza A Viruses Influences Susceptibility to Broadly Neutralizing Stem Antibodies

Autor: Wei Wang, Carol D. Weiss, Hyo Sook Song, Paul W. Keller, Russell Vassell, Esmeralda Alvarado-Facundo

Publikováno v: Journal of Virology

Vaccines that elicit broadly neutralizing antibodies to the conserved stem of hemagglutinin (HA) are being developed as universal influenza vaccines that protect against influenza across multiple years. However, different influenza virus strains, eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81153d71f1a515ce1dbd2c544a9cfbf2
https://pubmed.ncbi.nlm.nih.gov/29593038

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Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it

Autor: Carol D. Weiss, Hyo Sook Song, Falko Schmeisser, Hongquan Wan, Qiong Chen, Wei Wang, Jerry P. Weir, Russell Vassell, Clement A. Meseda, Swati Verma, Paul W. Keller, Esmeralda Alvarado-Facundo

Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 9, p e0222436 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdccb305477d4b584dd406868471b5a0
https://doi.org/10.1371/journal.pone.0222436

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In Sup35p filaments (the [PSI+] prion), the globular C-terminal domains are widely offset from the amyloid fibril backbone

Autor: Ulrich Baxa, Paul W. Keller, Alasdair C. Steven, Joseph S. Wall, Naiqian Cheng

Publikováno v: Molecular Microbiology. 79:523-532

In yeast cells infected with the [PSI+] prion, Sup35p forms aggregates and its activity in translation termination is downregulated. Transfection experiments have shown that Sup35p filaments assembled in vitro are infectious, suggesting that they rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a98e5a2fab4e0c2687be0dcc63e8c695
https://doi.org/10.1111/j.1365-2958.2010.07466.x

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The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone

Autor: Jennifer S. Dickey, Jacek Zielonka, Emily Shacter, Spencer J. Bonar, Balaraman Kalyanaraman, V. Ashutosh Rao, Joy Joseph, Naoko Mizuno, Paul W. Keller, Sarah R. Klein

Publikováno v: Journal of Biological Chemistry. 285:34447-34459

Mitoquinone (MitoQ) is a synthetically modified, redox-active ubiquinone compound that accumulates predominantly in mitochondria. We found that MitoQ is 30-fold more cytotoxic to breast cancer cells than to healthy mammary cells. MitoQ treatment led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb935cc9a6edfa887ae3e98a820345f
https://doi.org/10.1074/jbc.m110.133579

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Identification of an HIV-1 Mutation in Spacer Peptide 1 That Stabilizes the Immature CA-SP1 Lattice

Autor: Eric O. Freed, Sherimay D. Ablan, Emiko Urano, Alasdair C. Steven, Paul W. Keller, Juan Fontana

Publikováno v: Journal of virology. 90(2)

Upon release of HIV-1 particles from the infected cell, the viral protease cleaves the Gag polyprotein at specific sites, triggering maturation. During this process, which is essential for infectivity, the capsid protein (CA) reassembles into a conic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e375a85b47c6b5d13b9df7ef62691a29
https://pubmed.ncbi.nlm.nih.gov/26537676

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