Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Paul W. Heron"'
Publikováno v:
Journal of Medicinal Chemistry. 61:10558-10572
The glycolytic enzyme aldolase is an emerging drug target in diseases such as cancer and protozoan infections which are dependent on a hyperglycolytic phenotype to synthesize adenosine 5'-triphosphate and metabolic precursors for biomass production.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e80c3c1898ed765a4046c5ae82431ed
https://doi.org/10.1021/acs.jmedchem.8b01000
https://doi.org/10.1021/acs.jmedchem.8b01000
Autor:
Paul W. Heron, Jurgen Sygusch
Publikováno v:
Journal of Biological Chemistry. 292:19849-19860
Fructose-1,6-bisphosphate (FBP) aldolase, a glycolytic enzyme, catalyzes the reversible and stereospecific aldol addition of dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde 3-phosphate (d-G3P) by an unresolved mechanism. To afford insight into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda62b85b43c91a54375c8ea133024cf
https://doi.org/10.1074/jbc.m117.811034
https://doi.org/10.1074/jbc.m117.811034
Autor:
Agnieszka Gizak, Janusz Wiśniewski, Paul W. Heron, Dariusz Rakus, Jurgen Sygusch, Piotr Mamczur
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 10, Pp 1-16 (2019)
Cell Death and Disease, Vol 10, Iss 10, Pp 1-16 (2019)
Muscle fructose-1,6-bisphosphate aldolase (ALDOA) is among the most abundant glycolytic enzymes in all cancer cells. Here, we show that the enzyme plays a previously unknown and critical role in a cancer cell survival. Simultaneous inhibition of ALDO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e226e9b831eedc62b9750e904fc3a10
http://europepmc.org/articles/PMC6763475
http://europepmc.org/articles/PMC6763475
Autor:
Paul Pillot, Anne-Laure Chambon, Joelle Pelé, Clotilde LowKam, Jocelyne Falletto, Jurgen Sygusch, Morgane Leroux, Françoise Beylich, Vincent Barbier, Dominique Kajetanek, Celia Kremer, Magali Legris, Paul W. Heron
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C1037-C1037
If crystallography is well known to many scientists, this is not true for the general public. Aims of the international year of crystallography include the desire to increase public awareness, to stimulate the intellectual curiosity of students and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d7a0df0b032175d927bb71d6411cf4
https://doi.org/10.1107/s2053273314089621
https://doi.org/10.1107/s2053273314089621