Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Paul W. Groundwater"'
Autor:
Yiqun Chang, Bryson A. Hawkins, Jonathan J. Du, Paul W. Groundwater, David E. Hibbs, Felcia Lai
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 49 (2022)
The drug discovery process is a rocky path that is full of challenges, with the result that very few candidates progress from hit compound to a commercially available product, often due to factors, such as poor binding affinity, off-target effects, o
Externí odkaz:
https://doaj.org/article/2a39dc69ec314f6ca945248d1719c722
Autor:
Hsuan-Yu J. Lin, Rachana Rao Battaje, Jinlong Tan, Munikumar Doddareddy, Hemendra Pal Singh Dhaked, Shalini Srivastava, Bryson A. Hawkins, Laith Mohammad Hilal Al-Shdifat, David E. Hibbs, Dulal Panda, Paul W. Groundwater
Publikováno v:
Molecules, Vol 27, Iss 20, p 6993 (2022)
Multi-drug resistance is increasing in the pathogenic bacterium S. pneumoniae, which is mainly responsible for meningitis and community-acquired pneumonia (CAP), highlighting the need for new anti-pneumococcal agents. We have identified a potential a
Externí odkaz:
https://doaj.org/article/774da45091bd4f8d9c67dc71ce812f08
Publikováno v:
Molecules, Vol 24, Iss 19, p 3550 (2019)
Selective detection of β-alanyl aminopeptidase (BAP)-producing Pseudomonas aeruginosa, Serratia marcescens, and Burkholderia cepacia was achieved by employing the blue-to-yellow fluorescent transition of a BAP-specific enzyme substrate, 3-hydroxy-2-
Externí odkaz:
https://doaj.org/article/fa3cf067b88a491ebc3d80e30cbf3b04
Autor:
Jonathan J. Du, Felcia Lai, Linda Váradi, Peter A. Williams, Paul W. Groundwater, James A. Platts, David E. Hibbs, Jacob Overgaard
Publikováno v:
Crystals, Vol 8, Iss 1, p 46 (2018)
Paracetamol (PCM) has two well-documented polymorphic forms at room temperature; monoclinic Form I is more stable than the other orthorhombic Form II. Form II exhibits improved tabletting properties compared to Form I due to low shearing forces; howe
Externí odkaz:
https://doaj.org/article/eef13055d5d24e92ab20edcc19996e5d
Autor:
Paul W. Groundwater, Miklós Nyerges, Imre Fejes, David E. Hibbs, David Bendell, Rosaleen J. Anderson, Alexander McKillop, Toqir Sharif, Weimin Zhang
Publikováno v:
ARKIVOC, Vol 2000, Iss 5, Pp 684-697 (2000)
Externí odkaz:
https://doaj.org/article/85feb40546894b1da95f0311e63de167
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 8, Pp o2536-o2536 (2012)
The title compound, C21H26N2O5, was unexpectedly obtained as a by-product in the reaction of ethyl acetoacetate, 4-acetamidobenzaldehyde and urea under microwave irradiation. The dihydropyridine ring assumes a flattened boat conformation. Intermolecu
Externí odkaz:
https://doaj.org/article/472e36171ff647cf9af1183523213798
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 8, Pp o1885-o1885 (2011)
In the title compound, C21H20O4, the central heptatrienone unit is approximately planar, with a maximum atomic deviation of 0.1121 (11) Å; the two benzene rings are twisted with respect to the heptatrienone mean plane by 2.73 (5) and 29.31 (4)°. Th
Externí odkaz:
https://doaj.org/article/daea0d90c3114d3e92b11968a7799c0e
Autor:
Pooja J Batra, Anuradha Kumari, Vivian W Y Liao, David E Hibbs, Paul W Groundwater, Dulal Panda
Publikováno v:
The Journal of Biochemistry.
Here, we show that 3,5-bis[(1E)-2-(2,6-dichlorophenyl)ethenyl]-1H-pyrazole 2l depolymerizes microtubules and reduces the number of growing tips of microtubules. The fluorescence recovery after photobleaching experiment in live MCF-7 cells showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::253dbd6782c6e2385b4993a71618ca03
https://doi.org/10.1093/jb/mvad031
https://doi.org/10.1093/jb/mvad031
Understanding Hygroscopicity of Theophylline via a Novel Cocrystal Polymorph: A Charge Density Study
Autor:
Jennifer Ong, David E. Hibbs, Gyte Stanton, Bryson A. Hawkins, Stephen A. Stanton, Paul W. Groundwater, James Alexis Platts, Felcia Lai, Jonathan J. Du
Publikováno v:
The Journal of Physical Chemistry A. 125:9736-9756
The charge density distribution in a novel cocrystal (1) complex of 1,3-dimethylxanthine (theophylline) and propanedioic acid (malonic acid) has been determined. The molecules crystallize in the triclinic, centrosymmetric space group P1̅, with four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fd59984cbb0f84089569f8f55f86d2
https://doi.org/10.1021/acs.jpca.0c09536
https://doi.org/10.1021/acs.jpca.0c09536
Autor:
Christy El-Khoury, Elissar Mansour, Yori Yuliandra, Felcia Lai, Bryson A. Hawkins, Jonathan J. Du, Eric J. Sundberg, Nicolas Sluis-Cremer, David E. Hibbs, Paul W. Groundwater
Publikováno v:
RSC medicinal chemistry. 13(11)
Antibacterial resistance is a prominent issue with monotherapy often leading to treatment failure in serious infections. Many mechanisms can lead to antibacterial resistance including deactivation of antibacterial agents by bacterial enzymes. Enzymat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ddd311445b31a582f98126828293eb
https://pubmed.ncbi.nlm.nih.gov/36439977
https://pubmed.ncbi.nlm.nih.gov/36439977