Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Paul W. Fletcher"'
Autor:
Søren Østergaard, Ku-Chuan Hsiao, Jane Spetzler, Renuka C. Pillutla, Lauge Schäffer, Asser Sloth Andersen, James R. Beasley, Michael Lennick, Gillian M. Danielsen, Paul W. Fletcher, Per Hertz Hansen, Renee Brissette, Neil I. Goldstein, Jakob Brandt, Arthur J. Blume
Publikováno v:
Journal of Biological Chemistry. 277:22590-22594
We used phage display to generate surrogate peptides that define the hotspots involved in protein-protein interaction between insulin and the insulin receptor. All of the peptides competed for insulin binding and had affinity constants in the high na
Publikováno v:
Journal of Cellular Physiology. 173:387-396
We determined whether activation of phosphatidylinositol-specific phospholipase C (PI-PLC) and a subsequent increase in cytosolic calcium concentration ([Ca2+]i) was an obligatory signaling event mediating the increase in transendothelial permeabilit
Autor:
Paul W. Fletcher, Michael Aschner, Harold K. Kimelberg, Judy L. Aschner, Vijendra Dave, D. Vitarella
Publikováno v:
Brain Research. 618:9-18
Alteration of receptor-mediated signal transduction pathways by inorganic lead (Pb) has been postulated to contribute to the neurotoxicity of this environmental toxicant, some of these effects involving astrocytes. As Pb is known to mimic Ca2+ in var
Autor:
Neil I. Goldstein, Jakob Brandt, Asser Sloth Andersen, Jane Spetzler, Søren Østergaard, Michael Lennick, Thomas Hoeg-Jensen, Arthur J. Blume, Lauge Schäffer, Ulla Ribel, Paul W. Fletcher, Per Hertz Hansen, Gillian M. Danielsen, Renee Brissette, Renuka C. Pillutla, Jan Markussen, Olga Dedova, Ku-Chuan Hsiao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(8)
Insulin is thought to elicit its effects by crosslinking the two extracellular α-subunits of its receptor, thereby inducing a conformational change in the receptor, which activates the intracellular tyrosine kinase signaling cascade. Previously we i
Autor:
Stephen M. Festin, Herbert I. Jacobson, James A. Bennett, Daniel D Shaye, Paul W. Fletcher, Thomas T. Andersen
Publikováno v:
Biochimica et biophysica acta. 1427(2)
Previous studies have shown that alpha-fetoprotein (AFP) interferes with estrogen (E2)-stimulated growth, including E2-stimulated breast cancer growth. In an effort to localize the antiestrotrophic portion of the molecule, the C-terminal one-third (2
Publikováno v:
The American journal of physiology. 263(2 Pt 1)
The temporal relationship between the alpha-thrombin-induced increase in transendothelial permeability and the alpha-thrombin-mediated changes in several key transmembrane signaling events was examined in confluent monolayers of bovine pulmonary arte
Publikováno v:
Synapse (New York, N.Y.). 11(1)
Bovine area postrema tissue was used as a convenient source of tissue for studies of brain 5HT3 receptor density was determined to be 97 ± 5 fmol/mg and 124 ± 10 fmol/mg of protein using the commercially available 5HT3 radioligands, 3H-GR65630 and
Publikováno v:
Brain research. 532(1-2)
NAN-190 has been reported to be a 5-HT1A antagonist in drug discrimination studies. In order to determine if the effect of NAN-190 was directly due to competitive inhibition at 5-HT1A receptors, 5-HT1A-mediated inhibition of adenylyl cyclase in hippo
Autor:
Ku-Chuan Hsiao, Michael Lennick, Neil I. Goldstein, Vanessa Rodriguez, Paul W. Fletcher, Renee Brissette, Arthur J. Blume, Pinger Wang
Publikováno v:
Proteome Science. 1:1
Hotspots are defined as the minimal functional domains involved in protein:protein interactions and sufficient to induce a biological response. Here we describe the use of complex and high diversity phage display libraries to isolate peptides (called
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 263:1-1
Pages L219–L225: Hazel Lum, Judy L. Aschner, Patricia G. Phillips, Paul W. Fletcher, and Asrar B. Malik. “Time course of thrombin-induced increase in endothelial permeability: relationship to Cai2+ and inositol polyphosphates. ” Page L222: the