Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Paul W. Doetsch"'
Autor:
Libertad García-Villada, Natalya P. Degtyareva, Ashley M. Brooks, Joanna B. Goldberg, Paul W. Doetsch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pseudomonas aeruginosa is a major cause of nosocomial infections and the leading cause of chronic lung infections in cystic fibrosis and chronic obstructive pulmonary disease patients. Antibiotic treatment remains challenging because P. aeru
Externí odkaz:
https://doaj.org/article/941eb32df4344fcd83e39f2e70f669eb
Autor:
Guo Chen, Yin Luo, Kurt Warncke, Youwei Sun, David S. Yu, Haian Fu, Madhusmita Behera, Suresh S. Ramalingam, Paul W. Doetsch, Duc M. Duong, Michael Lammers, Walter J. Curran, Xingming Deng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are mo
Externí odkaz:
https://doaj.org/article/d07d654e84db43299a467240e28b6a80
Autor:
Waaqo Daddacha, Allyson E. Koyen, Amanda J. Bastien, PamelaSara E. Head, Vishal R. Dhere, Geraldine N. Nabeta, Erin C. Connolly, Erica Werner, Matthew Z. Madden, Michele B. Daly, Elizabeth V. Minten, Donna R. Whelan, Ashley J. Schlafstein, Hui Zhang, Roopesh Anand, Christine Doronio, Allison E. Withers, Caitlin Shepard, Ranjini K. Sundaram, Xingming Deng, William S. Dynan, Ya Wang, Ranjit S. Bindra, Petr Cejka, Eli Rothenberg, Paul W. Doetsch, Baek Kim, David S. Yu
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1921-1935 (2017)
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associate
Externí odkaz:
https://doaj.org/article/0fff215953bf4b47a57af665f31bccaf
Autor:
Hui Zhang, PamelaSara E. Head, Waaqo Daddacha, Seong-Hoon Park, Xingzhe Li, Yunfeng Pan, Matthew Z. Madden, Duc M. Duong, Maohua Xie, Bing Yu, Matthew D. Warren, Elaine A. Liu, Vishal R. Dhere, Chunyang Li, Ivan Pradilla, Mylin A. Torres, Ya Wang, William S. Dynan, Paul W. Doetsch, Xingming Deng, Nicholas T. Seyfried, David Gius, David S. Yu
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1435-1447 (2016)
The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role of the sirtuin 2 (SIRT2) acetylome in regulating this pathway is not clear. We found that deacetylation of ATR-interactin
Externí odkaz:
https://doaj.org/article/f2ddce6c8fc04efcab79c55c54406ab7
Autor:
Zhaozhong Li, Taofeek K. Owonikoko, Shi-Yong Sun, Suresh S. Ramalingam, Paul W. Doetsch, Zhi-Qiang Xiao, Fadlo R. Khuri, Walter J. Curran, Xingming Deng
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 12, Pp 1190-1202 (2012)
c-Myc is a transcriptional factor that functions as a central regulator of cell growth, proliferation, and apoptosis. Overexpression of c-Myc also enhances DNA double-strand breaks (DSBs), genetic instability, and tumorigenesis. However, the mechanis
Externí odkaz:
https://doaj.org/article/5e14fa5e306c4a8b95fd0035a837401f
Autor:
Damien Brégeon, Paul W. Doetsch
Publikováno v:
BioTechniques, Vol 37, Iss 5, Pp 760-766 (2004)
Cells of all living organisms are continuously exposed to physical and chemical agents that damage DNA and alter the integrity of their genomes. Despite the relatively high efficiency of the different repair pathways, some lesions remain in DNA when
Externí odkaz:
https://doaj.org/article/10bcd0e4b2a24253a52555a6858c897a
Autor:
Natalya P Degtyareva, Victoria C Placentra, Scott A Gabel, Leszek J Klimczak, Dmitry A Gordenin, Brett A Wagner, Garry R Buettner, Geoffrey A Mueller, Tatyana I Smirnova, Paul W Doetsch
Publikováno v:
Nucleic Acids Res
Mutational signatures discerned in cancer genomes, in aging tissues and in cells exposed to toxic agents, reflect complex processes underlying transformation of cells from normal to dysfunctional. Due to its ubiquitous and chronic nature, redox stres
Autor:
Xingming Deng, Paul W. Doetsch, Walter J. Curran, Fadlo R. Khuri, Suresh S. Ramalingam, Taofeek K. Owonikoko, Yun Yen, Maohua Xie
PDF file - 54K, Bcl2 interacts with p53R2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b243c3687a26fd1f2c43c79ee41cc3
https://doi.org/10.1158/0008-5472.22401360.v1
https://doi.org/10.1158/0008-5472.22401360.v1
Autor:
Xingming Deng, Paul W. Doetsch, Walter J. Curran, Fadlo R. Khuri, Suresh S. Ramalingam, Taofeek K. Owonikoko, Yun Yen, Maohua Xie
PDF file - 111K, Bcl2 downregulates intracellular dNTPs via inhibition of RNR activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b6795caa286b793e2ae4f425ab5863
https://doi.org/10.1158/0008-5472.22401366
https://doi.org/10.1158/0008-5472.22401366
Autor:
Xingming Deng, Paul W. Doetsch, Walter J. Curran, Fadlo R. Khuri, Suresh S. Ramalingam, Taofeek K. Owonikoko, Yun Yen, Maohua Xie
PDF file - 142K, Expression of exogenous Bcl2 in H1299 cells reduces the formation of hRRM1/hRRM2 complexes, which requires the BH4 domain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46efdcb151b7f533bc5d3e93d68b8640
https://doi.org/10.1158/0008-5472.22401357.v1
https://doi.org/10.1158/0008-5472.22401357.v1