Výsledky vyhledávání - "Paul W Young"

Akademický článek

Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.

Autor: Joan A Lenihan, Orthis Saha, Paul W Young

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187352 (2017)

Ligand of Numb protein X1 (LNX1) is an E3 ubiquitin ligase that contains a catalytic RING (Really Interesting New Gene) domain and four PDZ (PSD-95, DlgA, ZO-1) domains. LNX1 can ubiquitinate Numb, as well as a number of other ligands. However, the p

Externí odkaz: https://doaj.org/article/5097463fdc094bb0869ca7bac7e18441

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Akademický článek

The Importance of Alpha-Actinin Proteins in Platelet Formation and Function, and Their Causative Role in Congenital Macrothrombocytopenia

Autor: Leanne R. O’Sullivan, Mary R. Cahill, Paul W. Young

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 17, p 9363 (2021)

The actin cytoskeleton plays a central role in platelet formation and function. Alpha-actinins (actinins) are actin filament crosslinking proteins that are prominently expressed in platelets and have been studied in relation to their role in platelet

Externí odkaz: https://doaj.org/article/15854366fa0f4703b42d3d3794c357c0

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Actinin Family

Autor: Paul W. Young, Amarendra Praburam Ajaykumar

Publikováno v: Encyclopedia of Signaling Molecules ISBN: 9781461464389

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c09b709feb474d96cf8e1954288f48e
https://doi.org/10.1007/978-3-319-67199-4_101924

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Repeat Treatment of Obese Mice With BRL 49653, a New Potent Insulin Sensitizer, Enhances Insulin Action in White Adipocytes: Association With Increased Insulin Binding and Cell-Surface GLUT4 as Measured by Photoaffinity Labeling

Autor: Paul W Young, I. J. Kozka, Stephen A. Smith, Michael A. Cawthorne, P.J. Coyle, Carolyn A. Lister, David M Kirkham, Julie C. Holder, Geoffrey D. Holman

Publikováno v: Diabetes. 44:1087-1092

(±)-5-([4-[2-Methyl-2(pyridylamino)ethoxy]phenyl]methyl) 2,4-thiazolidinedione (BRL 49653) is a new potent antidiabetic agent that improves insulin sensitivity in animal models of NIDDM. In C57BL/6 obese (ob/ob) mice, BRL 49653, included in the diet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007e5f7fc306a888190aff9c3e55dbe6
https://doi.org/10.2337/diab.44.9.1087

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Synthesis of a selective alpha-2A adrenoceptor antagonist, BRL 48962, and its characterization at cloned human alpha-adrenoceptors

Autor: Caroline Jeanne Margaret Rockell, Lee James Beeley, Paul W. Young, Helen Chapman, Diane P. Naselsky, Paul Hieble, John M. Berge, John Kelly

Publikováno v: Bioorganicmedicinal chemistry. 3(12)

The chiral synthesis of the potent and selective alpha-2A antagonist, BRL 48962, is described. Evaluation of BRL 48962 at cloned human alpha-adrenoceptors indicates that this antagonist has a selectivity in the order of 30-fold for the alpha-2A subty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30eae9a8e1b6c198c1783bdf976bbb4
https://pubmed.ncbi.nlm.nih.gov/8770394

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Akademický článek

An analysis of splicing, actin-binding properties, heterodimerization and molecular interactions of the non-muscle a-actinins.

Autor: FOLEY, Kate S., Paul W. YOUNG

Publikováno v: Biochemical Journal; 6/15/2013, Vol. 452 Issue 3, following p477-488, 14p

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