Designing and testing broadly-protective filoviral vaccines optimized for cytotoxic T-lymphocyte epitope coverage.

Autor: Paul W Fenimore, Majidat A Muhammad, William M Fischer, Brian T Foley, Russell R Bakken, James R Thurmond, Karina Yusim, Hyejin Yoon, Michael Parker, Mary Kate Hart, John M Dye, Bette Korber, Carla Kuiken

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e44769 (2012)

We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the Human Immunodeficiency Virus type 1 (HIV-1) but also appropriate for Hepatitis C virus (HCV) a

Externí odkaz: https://doaj.org/article/dad067caf3604da993bc5c6b4a7606b3

Integrative structural studies of the SARS-CoV-2 spike protein during the fusion process (2022)

Autor: Jacob C. Miner, Paul W. Fenimore, William M. Fischer, Benjamin H. McMahon, Karissa Y. Sanbonmatsu, Chang-Shung Tung

Publikováno v: Current Research in Structural Biology, Vol 4, Iss , Pp 220-230 (2022)

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic and catastrophic, worldwide health and economic impacts. The spike protein on the viral surface is responsible for viral entry into the host cell. The binding of spike protein to the host

Externí odkaz: https://doaj.org/article/384dded28dd64ff283f79de4aa7b248b

Modeling the Influenza A NP-vRNA-Polymerase Complex in Atomic Detail

Autor: Jacob C. Miner, Anna Lappala, Paul W. Fenimore, William M. Fischer, Benjamin H. McMahon, Nicolas W. Hengartner, Karissa Y. Sanbonmatsu, Chang-Shung Tung

Publikováno v: Biomolecules, Vol 11, Iss 1, p 124 (2021)

Seasonal flu is an acute respiratory disease that exacts a massive toll on human populations, healthcare systems and economies. The disease is caused by an enveloped Influenza virus containing eight ribonucleoprotein (RNP) complexes. Each RNP incorpo

Externí odkaz: https://doaj.org/article/dd2866bbea854faa8d13e4ff9feb6e21

Neutron scattering in the biological sciences: progress and prospects

Autor: Hugh O'Neill, Kushol Gupta, David Fushman, Raquel L. Lieberman, John P. Marino, Edward Lyman, Loukas Petridis, Xiaolin Cheng, Christopher B. Stanley, Frederick Herberle, Yimin Mao, Alexei P. Sokolov, David J.E. Callaway, Yang Zhang, Frank Heinrich, Judith Peters, Robert M. Briber, Xiang-Qiang Chu, Paul W. Fenimore, Liang Hong, Joseph E. Curtis, Flora Meilleur, Jeremy C. Smith, Peter C. E. Moody, Andrey Kovalevsky, William B. O'Dell, Rana Ashkar, Frank Gabel, Mark Dadmun, Norman Wagner, Troy Wymore, Susan Krueger, Michael Weinrich, Kevin L. Weiss, Eugenia Kharlampieva, Hassina Z. Bilheux, Gerald R. Kneller, Mathias Lösche, Ursula Perez-Salas, Heliosa Bordallo, Zvi Kelman, Paul Langan, John Katsaras, Yun Liu, Carla Mattos, Jonathan D. Nickels

Publikováno v: Acta crystallographica. Section D, Structural biology
Acta crystallographica. Section D, Structural biology, International Union of Crystallography, 2018, 74 (12), pp.1129-1168. ⟨10.1107/S2059798318017503⟩
Acta crystallographica Section D : Structural biology [1993-...]
Acta crystallographica Section D : Structural biology [1993-..], 2018, 74 (12), pp.1129-1168. ⟨10.1107/S2059798318017503⟩

International audience; The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7cac286c1bc5446b7587d3880a1f20
https://pubmed.ncbi.nlm.nih.gov/30605130

Connectivity and free-surface effects in polymer glasses

Autor: Paul W. Fenimore, Eugene M. Terentjev, Anna Lappala, Luke Sefton

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)

The glass transition is one of the few unsolved problems in condensed matter physics: agreement on the cause of the slowing down of structural relaxation in glass-forming liquids is lacking. Glasses are amorphous solids, which do not possess the long

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d45a1e066d58df9418aafd1f7b5c45
https://pubmed.ncbi.nlm.nih.gov/30846731