Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance.

Autor: Heather M Fritz, Paul W Bowyer, Matthew Bogyo, Patricia A Conrad, John C Boothroyd

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29955 (2012)

Toxoplasma gondii is an obligate intracellular parasite that is unique in its ability to infect a broad range of birds and mammals, including humans, leading to an extremely high worldwide prevalence and distribution. This work focuses on the environ

Externí odkaz: https://doaj.org/article/a80363bbdd694a5bbb9596b1a647e1c9

Expanding the Malaria Antibody Toolkit: Development and Characterisation of Plasmodium falciparum RH5, CyRPA, and CSP Recombinant Human Monoclonal Antibodies

Autor: Adéla Nacer, Gaily Kivi, Raini Pert, Erkki Juronen, Pavlo Holenya, Eduardo Aliprandini, Rogerio Amino, Olivier Silvie, Doris Quinkert, Yann Le Duff, Matthew Hurley, Ulf Reimer, Andres Tover, Simon J. Draper, Sarah Gilbert, Mei Mei Ho, Paul W. Bowyer

Publikováno v: Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, 2022, 12, pp.901253. ⟨10.3389/fcimb.2022.901253⟩

Malaria, an infection caused by apicomplexan parasites of the genusPlasmodium, continues to exact a significant toll on public health with over 200 million cases world-wide, and annual deaths in excess of 600,000. Considerable progress has been made

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b123d88bf5ea3a189c21fdd4014e46aa
https://doi.org/10.3389/fcimb.2022.901253

Heterotypic interactions drive antibody synergy against a malaria vaccine candidate

Autor: Robert J, Ragotte, David, Pulido, Amelia M, Lias, Doris, Quinkert, Daniel G W, Alanine, Abhishek, Jamwal, Hannah, Davies, Adéla, Nacer, Edward D, Lowe, Geoffrey W, Grime, Joseph J, Illingworth, Robert F, Donat, Elspeth F, Garman, Paul W, Bowyer, Matthew K, Higgins, Simon J, Draper

Publikováno v: Nature communications. 13(1)

Understanding mechanisms of antibody synergy is important for vaccine design and antibody cocktail development. Examples of synergy between antibodies are well-documented, but the mechanisms underlying these relationships often remain poorly understo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7661131b60b6a79f4e393bbc0d9d5929
https://pubmed.ncbi.nlm.nih.gov/35177602

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG)

Autor: Nathalie Bouloc, Paul W. Bowyer, Keith H. Ansell, Jonathan M. Large, Kristian Birchall, Catherine A. Kettleborough, Denise J. Tsagris, David A. Baker, Ela Smiljanic-Hurley, Mary C. Wheldon, Lindsay B. Stewart, David Whalley, Simon A. Osborne, Andy Merritt

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:3168-3173

A series of trisubstituted thiazoles have been identified as potent inhibitors of Plasmodium falciparum (Pf) cGMP-dependent protein kinase (PfPKG) through template hopping from known Eimeria PKG (EtPKG) inhibitors. The thiazole series has yielded com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b91d780c2345c0f96aac2b5f0ee17a
https://doi.org/10.1016/j.bmcl.2018.08.028

Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1-4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies

Autor: Chetan E. Chitnis, Paul W. Bowyer, Ross L. Coppel, Itziar Ubillos, Marta Vidal, Deepak Gaur, Ruth Aguilar, Joseph J. Campo, David E. Lanar, Evelina Angov, Alfons Jiménez, James G. Beeson, Virander S. Chauhan, Sheetij Dutta, Benoit Gamain, David R. Cavanagh, Carlota Dobaño

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Malaria Journal, Vol 17, Iss 1, Pp 1-15 (2018)
Malaria Journal
Recercat. Dipósit de la Recerca de Catalunya
instname
Malaria Journal, BioMed Central, 2018, 17 (1), ⟨10.1186/s12936-018-2369-3⟩
Ubillos, I, Jiménez, A, Vidal, M, Bowyer, P W, Gaur, D, Dutta, S, Gamain, B, Coppel, R, Chauhan, V, Lanar, D, Chitnis, C, Angov, E, Beeson, J, Cavanagh, D, Campo, J J, Aguilar, R & Dobaño, C 2018, ' Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG 1-4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies ', Malaria Journal, vol. 17, no. 1, pp. 219 . https://doi.org/10.1186/s12936-018-2369-3

Background The quantitative suspension array technology (qSAT) is a useful platform for malaria immune marker discovery. However, a major challenge for large sero-epidemiological and malaria vaccine studies is the comparability across laboratories, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef3b980db629ec41e851524227d1fd7
http://hdl.handle.net/2445/134633