Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Paul W, Paré"'
Publikováno v:
Plants, Vol 13, Iss 19, p 2744 (2024)
Angelica sinensis is an alpine medicinal plant that has been widely used as a general blood tonic and gynecological indications over 2000 years, which depend on the bioactive metabolites (e.g., volatile oils, organic acids, and flavonoids). Although
Externí odkaz:
https://doaj.org/article/ba81be05c7a647c1814f3be0ae828503
Publikováno v:
Antibiotics, Vol 13, Iss 8, p 745 (2024)
Multidrug-resistant bacteria present a significant public health challenge; such pathogens exhibit reduced susceptibility to conventional antibiotics, limiting current treatment options. Cationic non-ribosomal peptides (CNRPs) such as brevicidine and
Externí odkaz:
https://doaj.org/article/eaef5923b4e3423abd64fac93409512b
Autor:
Mahmoud A A Ibrahim, Doaa G M Mahmoud, Alaa H M Abdelrahman, Khlood A A Abdeljawaad, Gamal A H Mekhemer, Tamer Shoeib, Mohamed A El-Tayeb, Peter A Sidhom, Paul W Paré, Mohamed-Elamir F Hegazy
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0314422 (2024)
Mycobacterium tuberculosis is a lethal human pathogen, with the key flavoenzyme for catalyzing bacterial cell-wall biosynthesis, decaprenylphosphoryl-D-ribose oxidase (DprE1), considered an Achilles heal for tuberculosis (TB) progression. Inhibition
Externí odkaz:
https://doaj.org/article/6c92a5a385c64c51a5c98e91b80b1e72
Autor:
Mahmoud A. A. Ibrahim, Sara S. M. Ali, Khlood A. A. Abdeljawaad, Alaa H. M. Abdelrahman, Gamal A. Gabr, Ahmed M. Shawky, Gamal A. H. Mekhemer, Peter A. Sidhom, Paul W. Paré, Mohamed-Elamir F. Hegazy
Publikováno v:
Journal of Taibah University for Science, Vol 17, Iss 1 (2023)
In the search for new metabolite inhibitors, a natural product activity and species source (NPASS) database was virtually screened using AutoDock software to identify potential NRP1 inhibitors. NPASS compounds complexed with NRP1 were subjected to mo
Externí odkaz:
https://doaj.org/article/220d62db63ee48d4affea6ff1e339d03
Autor:
Mahmoud A. A. Ibrahim, Mahmoud M. H. Abdelhamid, Khlood A. A. Abdeljawaad, Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Shaban R. M. Sayed, Paul W. Paré, Mohamed-Elamir F. Hegazy, Tamer Shoeib
Publikováno v:
Molecules, Vol 28, Iss 15, p 5713 (2023)
BRD4 (bromodomain-containing protein 4) is an epigenetic reader that realizes histone proteins and promotes the transcription of genes linked to cancer progression and non-cancer diseases such as acute heart failure and severe inflammation. The highl
Externí odkaz:
https://doaj.org/article/5a6c107947b948349a0ca2b761d038bb
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Hypericum perforatum, commonly known as St John’s wort, is a perennial herb that produces the anti-depression compounds hypericin (Hyp) and hyperforin. While cool temperatures increase plant growth, Hyp accumulation as well as changes transcript pr
Externí odkaz:
https://doaj.org/article/f99d25cab64a484fada29d5ab4ae6020
Autor:
Richa Kaushal, Li Peng, Sunil K. Singh, Mengrui Zhang, Xinlian Zhang, Juan I. Vílchez, Zhen Wang, Danxia He, Yu Yang, Suhui Lv, Zhongtian Xu, Rafael J. L. Morcillo, Wei Wang, Weichang Huang, Paul W. Paré, Chun-Peng Song, Jian-Kang Zhu, Renyi Liu, Wenxuan Zhong, Ping Ma, Huiming Zhang
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Background Plants are naturally associated with root microbiota, which are microbial communities influential to host fitness. Thus, it is important to understand how plants control root microbiota. Epigenetic factors regulate the readouts of
Externí odkaz:
https://doaj.org/article/b9d8b53972764a3b8393de53fc12cabe
Publikováno v:
Plants, Vol 12, Iss 3, p 575 (2023)
Sinopodophyllum hexandrum is a perennial alpine herb producing the anti-cancer metabolite podophyllotoxin (PPT). Although the adaptation of S. hexandrum to high altitudes has been demonstrated and the effects of temperature, precipitation, and UV-B l
Externí odkaz:
https://doaj.org/article/81aabd2b80604eb6819ee75cb821fd67
Autor:
Eman H. Reda, Nesrine M. Hegazi, Mona Marzouk, Zienab T. Abdel Shakour, Ali M. El-Halawany, El-Sayeda A. El-Kashoury, Tarik A. Mohamed, Mahmoud A. A. Ibrahim, Khaled A. Shams, Nahla S. Abdel-Azim, Christopher J. Kampf, Thomas Efferth, Paul. W. Paré, Mohamed-Elamir F. Hegazy
Publikováno v:
Molecules, Vol 28, Iss 2, p 674 (2023)
Centaurea is a genus compromising over 250 herbaceous flowering species and is used traditionally to treat several ailments. Among the Egyptian Centaurea species, C. lipii was reported to be cytotoxic against multidrug-resistant cancer cells. In this
Externí odkaz:
https://doaj.org/article/2eba775523554197a2763bd89b2126bd
Autor:
Mahmoud A. A. Ibrahim, Alaa H. M. Abdelrahman, Dina E. M. Mohamed, Khlood A. A. Abdeljawaad, Mohamed Ahmed Naeem, Gamal A. Gabr, Ahmed M. Shawky, Mahmoud E. S. Soliman, Peter A. Sidhom, Paul W. Paré, Mohamed-Elamir F. Hegazy
Publikováno v:
Viruses, Vol 15, Iss 1, p 250 (2023)
The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 6 million deaths. The 3C-like protease (3CLpro) enzyme of the SARS-CoV-2 virus is an attractive d
Externí odkaz:
https://doaj.org/article/9b889d0689364673945ed2c575f1957b