Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Paul W, Hruz"'
Autor:
Shawna L. McMillin, Parker L. Evans, William M. Taylor, Luke A. Weyrauch, Tyler J. Sermersheim, Steven S. Welc, Monique R. Heitmeier, Richard C. Hresko, Paul W. Hruz, Francoise Koumanov, Geoffrey D. Holman, E. Dale Abel, Carol A. Witczak
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1734 (2022)
Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated that mechanical overload, a model of resistance exercise training, increases muscle GLUT1 leve
Externí odkaz:
https://doaj.org/article/147a73ac6c2d4bab8a2344c5e3fe0de0
Autor:
Monique R. Heitmeier, Maria A. Payne, Carla Weinheimer, Attila Kovacs, Richard C. Hresko, Patrick Y. Jay, Paul W. Hruz
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract GLUT transgenic and knockout mice have provided valuable insight into the role of facilitative glucose transporters (GLUTs) in cardiovascular and metabolic disease, but compensatory physiological changes can hinder interpretation of these mo
Externí odkaz:
https://doaj.org/article/eeb94a2a3685407890ba31775830ba3a
Autor:
Rachel L. Edwards, Robert C. Brothers, Xu Wang, Maxim I. Maron, Peter D. Ziniel, Patricia S. Tsang, Thomas E. Kraft, Paul W. Hruz, Kim C. Williamson, Cynthia S. Dowd, Audrey R. Odom John
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the met
Externí odkaz:
https://doaj.org/article/539d6d0aabfc46c68f5a489b64e29fac
Autor:
Monique R Heitmeier, Richard C Hresko, Rachel L Edwards, Michael J Prinsen, Ma Xenia G Ilagan, Audrey R Odom John, Paul W Hruz
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as c
Externí odkaz:
https://doaj.org/article/5b482186f44d47e980b0f7cc11450eff
Autor:
Paul W. Hruz
Publikováno v:
The National Catholic Bioethics Quarterly. 19:89-104
Clinical guidelines now recommend hormonal and surgical interventions together with social affirmation for children who experience a gender identity that is discordant with their biological sex. However, fundamental questions regarding the safety,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60088da0dc53c6369b60a73570adeefd
https://doi.org/10.5840/ncbq20191918
https://doi.org/10.5840/ncbq20191918
Autor:
Peter Hung, William McAllister, Alecia Welscher, Maria S. Remedi, Paul W. Hruz, Christopher H. Emfinger, Colin G. Nichols, Zihan Yan
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 315:E1121-E1132
Gain-of-function (GOF) mutations in the ATP-sensitive potassium (KATP) channels cause neonatal diabetes. Despite the well-established genetic root of the disease, pathways modulating disease severity and treatment effectiveness remain poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409ba67e98043971edfd0b169877c7cb
https://doi.org/10.1152/ajpendo.00137.2018
https://doi.org/10.1152/ajpendo.00137.2018
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1efdb8fcd4a12474a097d0bc978c009
https://doi.org/10.1210/clinem/dgab205
https://doi.org/10.1210/clinem/dgab205
Autor:
Kartik Shankar, Belgacem Mihi, Phillip I. Tarr, Misty R. Good, Nurmohammad Shaikh, Cassandra B. Higgins, Umesh D. Wankhade, Jeremie L Ferey, Paul W. Hruz, Brian J. DeBosch, Monique R. Heitmeier, Yiming Zhang, Takanobu Higashiyama, Benjamin M. Swarts, Jan R. Crowley, Sree V. Chintapalli, Alicyn I Stothard
Publikováno v:
Gastroenterology
Background & Aims Trehalose is a disaccharide that might be used in the treatment of cardiometabolic diseases. However, trehalose consumption promotes the expansion of Clostridioides difficile ribotypes that metabolize trehalose via trehalose-6-phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab7e3dd3788ff036eca5bbbe3e80a25
https://europepmc.org/articles/PMC7103499/
https://europepmc.org/articles/PMC7103499/
Autor:
Babak Razani, Indira U. Mysorekar, Brian J. DeBosch, Allyson L. Mayer, Cassandra B. Higgins, Mark J. Graham, Paul W. Hruz, Yiming Zhang
Publikováno v:
Autophagy. 14:1959-1975
The macroautophagy/autophagy-inducing disaccharide, trehalose, has been proposed to be a promising therapeutic agent against neurodegenerative and cardiometabolic diseases. We recently showed that trehalose attenuates hepatic steatosis in part by blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57c870cc8746f8b011543cc732ac65e
https://doi.org/10.1080/15548627.2018.1493044
https://doi.org/10.1080/15548627.2018.1493044
Autor:
Arpita Kalla Vyas, Kai-Chien Yang, Dennis Woo, Anatoly Tzekov, Attila Kovacs, Patrick Y Jay, Paul W Hruz
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17178 (2011)
There is growing awareness of secondary insulin resistance and alterations in myocardial glucose utilization in congestive heart failure. Whether therapies that directly target these changes would be beneficial is unclear. We previously demonstrated
Externí odkaz:
https://doaj.org/article/78ccf4e41e83411190ae8c474fd1cb3f