Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Paul W, Bowyer"'
Autor:
Manuela C. Aguirre-Botero, Lawrence T. Wang, Pauline Formaglio, Eduardo Aliprandini, Jean-Michel Thiberge, Arne Schön, Yevel Flores-Garcia, Shamika Mathis-Torres, Barbara J. Flynn, Lais da Silva Pereira, Yann Le Duff, Mathew Hurley, Adéla Nacer, Paul W. Bowyer, Fidel Zavala, Azza H. Idris, Joseph R. Francica, Robert A. Seder, Rogerio Amino
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112681- (2023)
Summary: Human monoclonal antibodies (hmAbs) targeting the Plasmodium falciparum circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for preventing malaria infection. However, their mechanisms of protection remain unclear.
Externí odkaz:
https://doaj.org/article/0e7fe2937927407cbebd3d4c244d9741
Autor:
Robert J. Ragotte, David Pulido, Amelia M. Lias, Doris Quinkert, Daniel G. W. Alanine, Abhishek Jamwal, Hannah Davies, Adéla Nacer, Edward D. Lowe, Geoffrey W. Grime, Joseph J. Illingworth, Robert F. Donat, Elspeth F. Garman, Paul W. Bowyer, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Antibodies can have synergistic effects, but mechanisms are not well understood. Here, Ragotte et al. identify three antibodies that bind neighbouring epitopes on CyRPA, a malaria vaccine candidate, and show that lateral interactions between the anti
Externí odkaz:
https://doaj.org/article/311198660694450bbebda7b48bd4d1b2
Autor:
Adéla Nacer, Gaily Kivi, Raini Pert, Erkki Juronen, Pavlo Holenya, Eduardo Aliprandini, Rogerio Amino, Olivier Silvie, Doris Quinkert, Yann Le Duff, Matthew Hurley, Ulf Reimer, Andres Tover, Simon J. Draper, Sarah Gilbert, Mei Mei Ho, Paul W. Bowyer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Malaria, an infection caused by apicomplexan parasites of the genus Plasmodium, continues to exact a significant toll on public health with over 200 million cases world-wide, and annual deaths in excess of 600,000. Considerable progress has been made
Externí odkaz:
https://doaj.org/article/964ca94ca03a4486ab7310ec1cba72cb
Autor:
Itziar Ubillos, Alfons Jiménez, Marta Vidal, Paul W. Bowyer, Deepak Gaur, Sheetij Dutta, Benoit Gamain, Ross Coppel, Virander Chauhan, David Lanar, Chetan Chitnis, Evelina Angov, James Beeson, David Cavanagh, Joseph J. Campo, Ruth Aguilar, Carlota Dobaño
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-15 (2018)
Abstract Background The quantitative suspension array technology (qSAT) is a useful platform for malaria immune marker discovery. However, a major challenge for large sero-epidemiological and malaria vaccine studies is the comparability across labora
Externí odkaz:
https://doaj.org/article/5ba8377aef2545d38add042e560f8738
Autor:
David A. Baker, Lindsay B. Stewart, Jonathan M. Large, Paul W. Bowyer, Keith H. Ansell, María B. Jiménez-Díaz, Majida El Bakkouri, Kristian Birchall, Koen J. Dechering, Nathalie S. Bouloc, Peter J. Coombs, David Whalley, Denise J. Harding, Ela Smiljanic-Hurley, Mary C. Wheldon, Eloise M. Walker, Johannes T. Dessens, María José Lafuente, Laura M. Sanz, Francisco-Javier Gamo, Santiago B. Ferrer, Raymond Hui, Teun Bousema, Iñigo Angulo-Barturén, Andy T. Merritt, Simon L. Croft, Winston E. Gutteridge, Catherine A. Kettleborough, Simon A. Osborne
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth
Externí odkaz:
https://doaj.org/article/0c48607312374096801bf91f077ff9c0
Autor:
Donna Bryan, Nilupa Silva, Peter Rigsby, Thomas Dougall, Patrick Corran, Paul W. Bowyer, Mei Mei Ho, the Collaborative study group
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-10 (2017)
Abstract Background At a World Health Organization (WHO) sponsored meeting it was concluded that there is an urgent need for a reference preparation that contains antibodies against malaria antigens in order to support serology studies and vaccine de
Externí odkaz:
https://doaj.org/article/8b8276f1bb2e4862828e192288ae174b
Autor:
Robert J, Ragotte, David, Pulido, Amelia M, Lias, Doris, Quinkert, Daniel G W, Alanine, Abhishek, Jamwal, Hannah, Davies, Adéla, Nacer, Edward D, Lowe, Geoffrey W, Grime, Joseph J, Illingworth, Robert F, Donat, Elspeth F, Garman, Paul W, Bowyer, Matthew K, Higgins, Simon J, Draper
Publikováno v:
Nature communications. 13(1)
Understanding mechanisms of antibody synergy is important for vaccine design and antibody cocktail development. Examples of synergy between antibodies are well-documented, but the mechanisms underlying these relationships often remain poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7661131b60b6a79f4e393bbc0d9d5929
https://pubmed.ncbi.nlm.nih.gov/35177602
https://pubmed.ncbi.nlm.nih.gov/35177602
Autor:
Nathalie Bouloc, Kristian Birchall, Andy Merritt, Keith H. Ansell, David A. Baker, Paul W. Bowyer, David Whalley, Simon A. Osborne, Denise J. Tsagris, P.J. Coombs, Ela Smiljanic-Hurley, Jonathan M. Large, Lindsay B. Stewart, Mary C. Wheldon, Catherine A. Kettleborough
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Development of a class of bicyclic inhibitors of the Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG), starting from known compounds with activity against a related parasite PKG orthologue, is reported. Examin
Development of a class of bicyclic inhibitors of the Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG), starting from known compounds with activity against a related parasite PKG orthologue, is reported. Examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01a5f293ace057b567da68eeb378c47
https://doi.org/10.1016/j.bmcl.2018.11.039
https://doi.org/10.1016/j.bmcl.2018.11.039
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29955 (2012)
Toxoplasma gondii is an obligate intracellular parasite that is unique in its ability to infect a broad range of birds and mammals, including humans, leading to an extremely high worldwide prevalence and distribution. This work focuses on the environ
Externí odkaz:
https://doaj.org/article/a80363bbdd694a5bbb9596b1a647e1c9
Autor:
Nathalie Bouloc, Paul W. Bowyer, Keith H. Ansell, Jonathan M. Large, Kristian Birchall, Catherine A. Kettleborough, Denise J. Tsagris, David A. Baker, Ela Smiljanic-Hurley, Mary C. Wheldon, Lindsay B. Stewart, David Whalley, Simon A. Osborne, Andy Merritt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3168-3173
A series of trisubstituted thiazoles have been identified as potent inhibitors of Plasmodium falciparum (Pf) cGMP-dependent protein kinase (PfPKG) through template hopping from known Eimeria PKG (EtPKG) inhibitors. The thiazole series has yielded com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b91d780c2345c0f96aac2b5f0ee17a
https://doi.org/10.1016/j.bmcl.2018.08.028
https://doi.org/10.1016/j.bmcl.2018.08.028