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Adipose Triglyceride Lipase is needed for homeostatic control of Sterol Element-Binding Protein-1c driven hepatic lipogenesis

Autor: Peter J. Espenshade, Gerald Hoefler, Silvia Schauer, Rolf Breinbauer, Paul Vesely, Paola Peña de la Sancha, Wolfgang Sattler, Helga Reicher, Martina Schweiger, Rudolf Zechner, Beatrix I. Wieser

Sterol Regulatory Element-Binding Protein-1c (SREBP-1c) is translated as an inactive precursor-protein that is proteolytically activated to promote fatty-acid (FA) biosynthesis, when unsaturated (u)FAs are scarce. During fasting, however, lipogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::694ac37d960d4cde3b360afb718fc5cc
https://doi.org/10.1101/2020.11.02.363440

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Loss of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis

Autor: Johannes Fosselteder, Matthew G. Vander Heiden, H. Furkan Alkan, Juliane G. Bogner-Strauss, Paul Vesely, Martin Pichler, Hubert Hackl, Gerald Hoefler

BackgroundAspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of aspartate synthesis on metastasis has not been studied. We previously described that loss-of-aspartate glutamate carrier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4450e9af4c35241e60b6fbaf6ae5339

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Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling

Autor: Gabriele Schoiswohl, Isabelle Strießnig-Bina, Gerald Hoefler, Zhiyuan Tang, Hao Xie, Rudolf Zechner, Martina Schweiger, Paul Vesely, Benedikt Kien, Christoph Heier, Veronika Sexl

Publikováno v: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids

Aberrant fatty acid (FA) metabolism is a hallmark of proliferating cells, including untransformed fibroblasts or cancer cells. Lipolysis of intracellular triglyceride (TG) stores by adipose triglyceride lipase (ATGL) provides an important source of F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a93279905e2db7510035d278262e4d
https://pubmed.ncbi.nlm.nih.gov/32404277

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Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

Autor: Laura, Pajed, Carina, Wagner, Ulrike, Taschler, Renate, Schreiber, Stephanie, Kolleritsch, Nermeen, Fawzy, Isabella, Pototschnig, Gabriele, Schoiswohl, Lisa-Maria, Pusch, Beatrix I, Wieser, Paul, Vesely, Gerald, Hoefler, Thomas O, Eichmann, Robert, Zimmermann, Achim, Lass

Publikováno v: The Journal of Biological Chemistry

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and retinyl ester (RE) and triglyceride (TG). Mice globally lacking LAL accumulate CE most prominently in the liver. The severity of the CE accumulation phenotype progresses with age and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d316a73aa697d182aeb83ffefffbed5
https://pubmed.ncbi.nlm.nih.gov/31023823

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Micro RNA-124a Regulates Lipolysis via Adipose Triglyceride Lipase and Comparative Gene Identification 58

Autor: Anna Schwarz, Paul Vesely, Silvia Schauer, Elke Stadelmeyer, Rudolf Zechner, Heimo Strohmaier, Gerald Hoefler, Thiery Claudel, Suman K. Das

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 4, Pp 8555-8568 (2015)
International Journal of Molecular Sciences
Volume 16
Issue 4
Pages 8555-8568

Lipolysis is the biochemical pathway responsible for the catabolism of cellular triacylglycerol (TG). Lipolytic TG breakdown is a central metabolic process leading to the generation of free fatty acids (FA) and glycerol, thereby regulating lipid, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c4f4a4a99e7b813fc73e8f7df7e74c
http://www.mdpi.com/1422-0067/16/4/8555

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The role of AP-1 and epigenetics in ALCL

Autor: Lukas Kenner, Gerda Egger, Melanie R. Hassler, Ana-Iris Schiefer, Paul Vesely

Publikováno v: Frontiers in Bioscience. 7:226-235

Anaplastic large cell lymphoma (ALCL) is an aggressive, highly proliferative, T-cell lymphoma with increasing incidence worldwide. Anaplastic Lymphoma Kinase (ALK) fusions occur in about 50% of all cases. Most ALK positive cases of ALCL harbor the t(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066cf03fb4a216bf2330358224ad189f
https://doi.org/10.2741/s436

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Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis

Autor: Paul Vesely, Larry Gerace, Michael D. Huber, Kaustuv Datta

Publikováno v: The Journal of Cell Biology

Erlins are cholesterol-binding proteins that restrict the activation of SREBPs, key transcription factors for cholesterol and fatty acid biosynthetic genes, under conditions of cholesterol sufficiency.
Cellular cholesterol levels are controlled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2f79c0359c085a336c98a89e2ca8ef
https://doi.org/10.1083/jcb.201305076

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Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling

Autor: Gerda Egger, Afschin Soleiman, Paul Vesely, Michaela Schlederer, Pamina Pflegerl, Rainer Zenz, Richard Moriggl, Peter Petzelbauer, Tadamitsu Kishimoto, Erwin F. Wagner, Brigitte Hantusch, Arabella Meixner, Lukas Kenner, Günter Steiner, Elke Janig, Peter Wolf

Publikováno v: Proceedings of the National Academy of Sciences. 106:20423-20428

Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting various tissues. Involvement of B and T cells as well as increased cytokine levels have been associated with disease manifestation. Recently, we demonstrated that mice with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016d6511685e8bb091c77ed01e67d53e
https://doi.org/10.1073/pnas.0910371106

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The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling

Autor: Wilhelm G. Dirks, Isabella Bambach, Helmut Bergler, Paul Vesely, Rene G. Ott, Philipp B. Staber, Silvia Schauer, Lukas Kenner, Veronika Sexl, Kotaro Funato, Marshall E. Kadin, Naznin Haq, Andelko Hrzenjak, Werner Linkesch, Gerald Hoefler, Claudia Fuchs, David W. Sternberg

Publikováno v: Blood. 110:3374-3383

Anaplastic large cell lymphomas (ALCLs) are highly proliferating tumors that commonly express the AP-1 transcription factor JunB. ALK fusions occur in approximately 50% of ALCLs, and among these, 80% have the t(2;5) translocation with NPM-ALK express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab31878554e7a07fbd388504a8eaa9f4
https://doi.org/10.1182/blood-2007-02-071258

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Genes fromDebaryomyces hanseniiincrease salt tolerance inSaccharomyces cerevisiaeW303

Autor: Maria C. Loureiro-Dias, José Ramos, Catarina Prista, Anabel Almagro, Paul Vesely, Ana Soeiro

Publikováno v: FEMS Yeast Research. 2:151-157

The yeast Debaryomyces hansenii has been chosen as a model for molecular studies of tolerance to NaCl. A gene library was built and transformants of Saccharomyces cerevisiae W303 containing genes from D. hansenii were selected for their ability to gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b6d2910427b154e4453db226ef578b1
https://doi.org/10.1111/j.1567-1364.2002.tb00079.x

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