Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Paul Vesely"'
Autor:
Peter J. Espenshade, Gerald Hoefler, Silvia Schauer, Rolf Breinbauer, Paul Vesely, Paola Peña de la Sancha, Wolfgang Sattler, Helga Reicher, Martina Schweiger, Rudolf Zechner, Beatrix I. Wieser
Sterol Regulatory Element-Binding Protein-1c (SREBP-1c) is translated as an inactive precursor-protein that is proteolytically activated to promote fatty-acid (FA) biosynthesis, when unsaturated (u)FAs are scarce. During fasting, however, lipogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::694ac37d960d4cde3b360afb718fc5cc
https://doi.org/10.1101/2020.11.02.363440
https://doi.org/10.1101/2020.11.02.363440
Autor:
Johannes Fosselteder, Matthew G. Vander Heiden, H. Furkan Alkan, Juliane G. Bogner-Strauss, Paul Vesely, Martin Pichler, Hubert Hackl, Gerald Hoefler
BackgroundAspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of aspartate synthesis on metastasis has not been studied. We previously described that loss-of-aspartate glutamate carrier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4450e9af4c35241e60b6fbaf6ae5339
Autor:
Gabriele Schoiswohl, Isabelle Strießnig-Bina, Gerald Hoefler, Zhiyuan Tang, Hao Xie, Rudolf Zechner, Martina Schweiger, Paul Vesely, Benedikt Kien, Christoph Heier, Veronika Sexl
Publikováno v:
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
Aberrant fatty acid (FA) metabolism is a hallmark of proliferating cells, including untransformed fibroblasts or cancer cells. Lipolysis of intracellular triglyceride (TG) stores by adipose triglyceride lipase (ATGL) provides an important source of F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a93279905e2db7510035d278262e4d
https://pubmed.ncbi.nlm.nih.gov/32404277
https://pubmed.ncbi.nlm.nih.gov/32404277
Autor:
Laura, Pajed, Carina, Wagner, Ulrike, Taschler, Renate, Schreiber, Stephanie, Kolleritsch, Nermeen, Fawzy, Isabella, Pototschnig, Gabriele, Schoiswohl, Lisa-Maria, Pusch, Beatrix I, Wieser, Paul, Vesely, Gerald, Hoefler, Thomas O, Eichmann, Robert, Zimmermann, Achim, Lass
Publikováno v:
The Journal of Biological Chemistry
Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and retinyl ester (RE) and triglyceride (TG). Mice globally lacking LAL accumulate CE most prominently in the liver. The severity of the CE accumulation phenotype progresses with age and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d316a73aa697d182aeb83ffefffbed5
https://pubmed.ncbi.nlm.nih.gov/31023823
https://pubmed.ncbi.nlm.nih.gov/31023823
Autor:
Anna Schwarz, Paul Vesely, Silvia Schauer, Elke Stadelmeyer, Rudolf Zechner, Heimo Strohmaier, Gerald Hoefler, Thiery Claudel, Suman K. Das
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 4, Pp 8555-8568 (2015)
International Journal of Molecular Sciences
Volume 16
Issue 4
Pages 8555-8568
International Journal of Molecular Sciences
Volume 16
Issue 4
Pages 8555-8568
Lipolysis is the biochemical pathway responsible for the catabolism of cellular triacylglycerol (TG). Lipolytic TG breakdown is a central metabolic process leading to the generation of free fatty acids (FA) and glycerol, thereby regulating lipid, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c4f4a4a99e7b813fc73e8f7df7e74c
http://www.mdpi.com/1422-0067/16/4/8555
http://www.mdpi.com/1422-0067/16/4/8555
Publikováno v:
Frontiers in Bioscience. 7:226-235
Anaplastic large cell lymphoma (ALCL) is an aggressive, highly proliferative, T-cell lymphoma with increasing incidence worldwide. Anaplastic Lymphoma Kinase (ALK) fusions occur in about 50% of all cases. Most ALK positive cases of ALCL harbor the t(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066cf03fb4a216bf2330358224ad189f
https://doi.org/10.2741/s436
https://doi.org/10.2741/s436
Publikováno v:
The Journal of Cell Biology
Erlins are cholesterol-binding proteins that restrict the activation of SREBPs, key transcription factors for cholesterol and fatty acid biosynthetic genes, under conditions of cholesterol sufficiency.
Cellular cholesterol levels are controlled
Cellular cholesterol levels are controlled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2f79c0359c085a336c98a89e2ca8ef
https://doi.org/10.1083/jcb.201305076
https://doi.org/10.1083/jcb.201305076
Autor:
Gerda Egger, Afschin Soleiman, Paul Vesely, Michaela Schlederer, Pamina Pflegerl, Rainer Zenz, Richard Moriggl, Peter Petzelbauer, Tadamitsu Kishimoto, Erwin F. Wagner, Brigitte Hantusch, Arabella Meixner, Lukas Kenner, Günter Steiner, Elke Janig, Peter Wolf
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20423-20428
Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting various tissues. Involvement of B and T cells as well as increased cytokine levels have been associated with disease manifestation. Recently, we demonstrated that mice with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016d6511685e8bb091c77ed01e67d53e
https://doi.org/10.1073/pnas.0910371106
https://doi.org/10.1073/pnas.0910371106
Autor:
Wilhelm G. Dirks, Isabella Bambach, Helmut Bergler, Paul Vesely, Rene G. Ott, Philipp B. Staber, Silvia Schauer, Lukas Kenner, Veronika Sexl, Kotaro Funato, Marshall E. Kadin, Naznin Haq, Andelko Hrzenjak, Werner Linkesch, Gerald Hoefler, Claudia Fuchs, David W. Sternberg
Publikováno v:
Blood. 110:3374-3383
Anaplastic large cell lymphomas (ALCLs) are highly proliferating tumors that commonly express the AP-1 transcription factor JunB. ALK fusions occur in approximately 50% of ALCLs, and among these, 80% have the t(2;5) translocation with NPM-ALK express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab31878554e7a07fbd388504a8eaa9f4
https://doi.org/10.1182/blood-2007-02-071258
https://doi.org/10.1182/blood-2007-02-071258
Publikováno v:
FEMS Yeast Research. 2:151-157
The yeast Debaryomyces hansenii has been chosen as a model for molecular studies of tolerance to NaCl. A gene library was built and transformants of Saccharomyces cerevisiae W303 containing genes from D. hansenii were selected for their ability to gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b6d2910427b154e4453db226ef578b1
https://doi.org/10.1111/j.1567-1364.2002.tb00079.x
https://doi.org/10.1111/j.1567-1364.2002.tb00079.x