Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Paul Varley"'
Autor:
Caijuan Zhan, Gholamreza Bidkhori, Hubert Schwarz, Magdalena Malm, Aman Mebrahtu, Ray Field, Christopher Sellick, Diane Hatton, Paul Varley, Adil Mardinoglu, Johan Rockberg, Veronique Chotteau
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101653- (2020)
Summary: Human embryonic kidney cells HEK293 can be used for the production of therapeutic glycoproteins requiring human post-translational modifications. High cell density perfusion processes are advantageous for such production but are challenging
Externí odkaz:
https://doaj.org/article/3527cbee461a49d0a4b65321f003c3e5
Autor:
M. Moradi Barzadd, Anna-Luisa Volk, Diane Hatton, Raymond Field, Aman Mebrahtu, Paul Varley, R. G. Roth, Veronique Chotteau, N. Wistabacka, Fredrik Edfors, Chih-Chung Kuo, Magdalena Malm, Nathan E. Lewis, Ronia Razavi, T. Graslund, Johan Rockberg, David Kotol, M. Lunqvist
Publikováno v:
Metabolic Engineering. 72:171-187
Biologics represent the fastest growing group of therapeutics, but many advanced recombinant protein moieties remain difficult to produce. Here, we identify metabolic engineering targets limiting expression of recombinant human proteins through a sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0046abd38c8f4d0e6970b315d289d7
https://doi.org/10.1016/j.ymben.2022.03.009
https://doi.org/10.1016/j.ymben.2022.03.009
Autor:
Richard Turner, Christopher A. Sellick, Hubert Schwarz, Johan Rockberg, Raymond Field, Magdalena Malm, Paul Varley, Ye Zhang, Veronique Chotteau, Caijuan Zhan
Publikováno v:
Journal of Biotechnology. 309:44-52
Process intensification in mammalian cell culture-based recombinant protein production has been achieved by high cell density perfusion exceeding 10(8) cells/mL in the recent years. As the majority ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc81170e887409cbb16129b51311f0be
https://doi.org/10.1016/j.jbiotec.2019.12.017
https://doi.org/10.1016/j.jbiotec.2019.12.017
Autor:
Paul Varley
Publikováno v:
War in the early modern world ISBN: 9781003071013
Japan in the mid-fifteenth century was a country on the verge of disintegration. Its emperor, whose court was located in Kyoto, had not exercised real authority for centuries, but was a “sacred legitimizer” of the rule of others. From the late tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f342da7dc94c3a54f5f87f1a32a9c88c
https://doi.org/10.4324/9781003071013-3
https://doi.org/10.4324/9781003071013-3
Autor:
Veronique Chotteau, Paul Varley, Ray Field, Jens Nielsen, Luigi Grassi, Diane Hatton, Thomas Svensson, Rasool Saghaleyni, Johan Rockberg, Magnus Lundqvist, Marco Giudici, Magdalena Malm
Publikováno v:
Scientific Reports
Malm, M, Saghaleyni, R, Lundqvist, M, Giudici, M, Chotteau, V, Field, R, Varley, P G, Hatton, D, Grassi, L, Svensson, T, Nielsen, J & Rockberg, J 2020, ' Evolution from adherent to suspension: systems biology of HEK293 cell line development ', Scientific Reports, vol. 10, 18996 . https://doi.org/10.1038/s41598-020-76137-8
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Malm, M, Saghaleyni, R, Lundqvist, M, Giudici, M, Chotteau, V, Field, R, Varley, P G, Hatton, D, Grassi, L, Svensson, T, Nielsen, J & Rockberg, J 2020, ' Evolution from adherent to suspension: systems biology of HEK293 cell line development ', Scientific Reports, vol. 10, 18996 . https://doi.org/10.1038/s41598-020-76137-8
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
The need for new safe and efficacious therapies has led to an increased focus on biologics produced in mammalian cells. The human cell line HEK293 has bio-synthetic potential for human-like production attributes and is currently used for manufacturin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065ccb2419a777e8196c0b29f5c6f92c
https://doi.org/10.1101/2020.01.29.924894
https://doi.org/10.1101/2020.01.29.924894
Autor:
Thomas Svensson, Ray Field, Veronique Chotteau, Jens Nielsen, Luigi Grassi, Diane Hatton, Rasool Saghaleyni, Marco Giudici, Paul Varley, Johan Rockberg, Magnus Lundqvist, Magdalena Malm
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-2 (2021)
Scientific Reports
Scientific Reports
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a590008a6c027cf1f760a4011a9309b5
https://doaj.org/article/9b25893b02334dbda85e6f0d5d50fee7
https://doaj.org/article/9b25893b02334dbda85e6f0d5d50fee7
Autor:
Paul Varley
Tra i maggiori esperti di cultura giapponese, Paul Varley ha riassunto in questo volume un'intera vita di studi sul Paese del Sol Levante. Ricostruendone la storia dal Paleolitico al periodo medievale, dalla Restaurazione Meiji alla seconda guerra mo
Autor:
Caijuan Zhan, Gholamreza Bidkhori, Hubert Schwarz, Magdalena Malm, Aman Mebrahtu, Ray Field, Christopher Sellick, Diane Hatton, Paul Varley, Adil Mardinoglu, Johan Rockberg, Veronique Chotteau
Publikováno v:
iScience
iScience, Vol 23, Iss 11, Pp 101653-(2020)
iScience, Vol 23, Iss 11, Pp 101653-(2020)
Summary Human embryonic kidney cells HEK293 can be used for the production of therapeutic glycoproteins requiring human post-translational modifications. High cell density perfusion processes are advantageous for such production but are challenging d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::11d5e937e2f0e433d98c7612677d066e
https://pubmed.ncbi.nlm.nih.gov/33145483
https://pubmed.ncbi.nlm.nih.gov/33145483
Autor:
LanLan Xu, Björn Forsström, Fredrik Pontén, Roxana Mihai, Emil Lindström, Jan Mulder, Helian Vunk, Jahir M. Gutierrez, Evelina Sjöstedt, Johan Rockberg, Ray Fields, Andreas Hober, Åsa Sivertsson, Anna Berling, Jimmy Vuu, Melanie Dannemeyer, Bjørn G. Voldborg, Muna Muse, David Kotol, Fredrik Edfors, Lovisa Holmberg Schiavone, Lorenz M. Mayr, Hanna Tegel, Sinead Knight, Sven Göpel, Martin Zwahlen, Lucas Bremer, Bernhard O. Palsson, Sophia Hober, Rick Davies, Julia Scheffel, Borbala Katona, Anna-Luisa Volk, Linn Fagerberg, Sara Kanje, Magdalena Malm, Kalle von Feilitzen, Jenny Ottosson Takanen, Paul Varley, Magnus Lundqvist, Jochen M. Schwenk, Anne-Sophie Svensson, Diane Hatton, Mathias Uhlén, Malin Westin, Henric Enstedt, Adil Mardinoglu, Siri Ekblad, Delaram Afshari, Jens Nielsen, Cecilia Lindskog, Peter Nilsson, Charlotte Stadler, Chih-Chung Kuo, Nathan E. Lewis
The proteins secreted by human tissues (the secretome) are important for the basic understanding of human biology, but also for identification of potential targets for future diagnosis and therapy. Here, we present an annotated list of all predicted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a73a15cc6311194f4473e37b1f9ea88
Autor:
Paul Varley
Shintō means the ‘way of the kami (gods)’ and is a term that was evolved about the late sixth or early seventh centuries – as Japan entered an extended period of cultural borrowing from China and Korea – to distinguish the amalgam of native
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2acce18863c7934b2955e1a635d41d48
https://doi.org/10.4324/9780415249126-g102-1
https://doi.org/10.4324/9780415249126-g102-1