Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Paul Van Diest"'
Autor:
Chris Jenske de Witte, Jose Espejo Valle-Inclan, Nizar Hami, Kadi Lõhmussaar, Oded Kopper, Celien Philomena Henrieke Vreuls, Geertruida Nellie Jonges, Paul van Diest, Luan Nguyen, Hans Clevers, Wigard Pieter Kloosterman, Edwin Cuppen, Hugo Johannes Gerhardus Snippert, Ronald Peter Zweemer, Petronella Oda Witteveen, Ellen Stelloo
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107762- (2020)
Summary: There remains an unmet need for preclinical models to enable personalized therapy for ovarian cancer (OC) patients. Here we evaluate the capacity of patient-derived organoids (PDOs) to predict clinical drug response and functional consequenc
Externí odkaz:
https://doaj.org/article/710cd95200e946f6b51756da239c114a
Autor:
Karin Beelen, Mark Opdam, Tesa Severson, Rutger Koornstra, Andrew Vincent, Jelle Wesseling, Joyce Sanders, Jan Vermorken, Paul van Diest, Sabine Linn
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Controversy exists for the use of Ki67 protein expression as a predictive marker to select patients who do or do not derive benefit from adjuvant endocrine therapy. Whether other proliferation markers, like Cyclin D1, and mitotic
Externí odkaz:
https://doaj.org/article/c558154a46ac40b6b7bc562fdd869e71
Autor:
Stephin J Vervoort, Olivier G de Jong, M Guy Roukens, Cynthia L Frederiks, Jeroen F Vermeulen, Ana Rita Lourenço, Laura Bella, Ana Tufegdzic Vidakovic, José L Sandoval, Cathy Moelans, Miranda van Amersfoort, Margaret J Dallman, Alejandra Bruna, Carlos Caldas, Edward Nieuwenhuis, Elsken van der Wall, Patrick Derksen, Paul van Diest, Marianne C Verhaar, Eric W-F Lam, Michal Mokry, Paul J Coffer
Publikováno v:
eLife, Vol 7 (2018)
The expression of the transcription factor SOX4 is increased in many human cancers, however, the pro-oncogenic capacity of SOX4 can vary greatly depending on the type of tumor. Both the contextual nature and the mechanisms underlying the pro-oncogeni
Externí odkaz:
https://doaj.org/article/36ce755b8cc24e3d9cea3f932f2ee24e
Autor:
Evelyne Beerling, Daniëlle Seinstra, Elzo de Wit, Lennart Kester, Daphne van der Velden, Carrie Maynard, Ronny Schäfer, Paul van Diest, Emile Voest, Alexander van Oudenaarden, Nienke Vrisekoop, Jacco van Rheenen
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2281-2288 (2016)
Forced overexpression and/or downregulation of proteins regulating epithelial-to-mesenchymal transition (EMT) has been reported to alter metastasis by changing migration and stem cell capacity of tumor cells. However, these manipulations artificially
Externí odkaz:
https://doaj.org/article/2e0a3ea64e264b71986d59629f1e2f8d
Autor:
Winan J. van Houdt, Frederik J.H. Hoogwater, Menno T. de Bruijn, Benjamin L. Emmink, Maarten W. Nijkamp, Danielle A.E. Raats, Petra van der Groep, Paul van Diest, Inne H.M. Borel Rinkes, Onno Kranenburg
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 6, Pp 443-452 (2010)
Epidermal growth factor receptor (EGFR)-targeting therapeutics have shown efficacy in the treatment of colorectal cancer patients. Clinical studies have revealed that activating mutations in the KRAS protooncogene predict resistance to EGFR-targeted
Externí odkaz:
https://doaj.org/article/a17dd95799644a4085e7bad345f1f618
Autor:
Mario Hermsen, Marta Alonso Guervós, Gerrit Meijer, Paul van Diest, Carlos Suárez Nieto, Cesar Alvarez Marcos, Andrés Sampedro
Publikováno v:
Cellular Oncology, Vol 27, Iss 3, Pp 191-198 (2005)
Invasive head and neck squamous carcinomas are among the cytogenetically most complex tumors. Perhaps for this reason, there is little consensus on the prognostic value of specific chromosomal aberrations. Here we present Results of CGH analysis of 5
Externí odkaz:
https://doaj.org/article/dc2514a5e0f5424a8bfcf84dacabee3f
Autor:
Angelica Conversano, Muriel Abbaci, Paul van Diest, Aurélie Roulot, Giuseppe Falco, Malek Ferchiou, Saverio Coiro, Milan Richir, Pierre-Michel Genolet, Carine Clement, Odile Casiraghi, Aicha Ben Lahkdar, Nizard Labaied, Moira Ragazzi, Marie-Christine Mathieu
Publikováno v:
BJS Open. 7
Background New generation ultra-fast fluorescence confocal microscopy allows the ex vivo intraoperative analysis of fresh tissue. The High resolution Imaging for Breast carcInoma detection in ex vivo Specimens after breast Conserving sUrgery by hiSto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8bd9e5887affe74fcb424bd907a741
https://doi.org/10.1093/bjsopen/zrad046
https://doi.org/10.1093/bjsopen/zrad046
Publikováno v:
Breast Care.
Background: Most patients suffering from pathological nipple discharge (PND) undergo local surgical procedures because standard radiologic imaging often fails to reveal the cause. Ductoscopy is a minimally invasive endoscopic technique that enables d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96ab0b546f6fd5002026966ee9d96ab3
https://doi.org/10.1159/000530817
https://doi.org/10.1159/000530817
Autor:
Venu Raman, Carlotta Glackin, Horst Burger, Paul Van Diest, Zaver Bhujwalla, Dmitri Artemov, Scott Kominsky, Arvind P. Pathak, Flonne Wildes, Yoshinori Kato, Farhad Vesuna, Paul T. Winnard, Yelena Mironchik
Aggressive cancer phenotypes are a manifestation of many different genetic alterations that promote rapid proliferation and metastasis. In this study, we show that stable overexpression of Twist in a breast cancer cell line, MCF-7, altered its morpho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226764eb56bf3ab6eb3158891a2d6503
https://doi.org/10.1158/0008-5472.c.6494051
https://doi.org/10.1158/0008-5472.c.6494051
Autor:
Venu Raman, Carlotta Glackin, Horst Burger, Paul Van Diest, Zaver Bhujwalla, Dmitri Artemov, Scott Kominsky, Arvind P. Pathak, Flonne Wildes, Yoshinori Kato, Farhad Vesuna, Paul T. Winnard, Yelena Mironchik
Supplementary Figure Legends from Twist Overexpression Induces In vivo Angiogenesis and Correlates with Chromosomal Instability in Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5193fc1d114e87f72dfdc43669e3c727
https://doi.org/10.1158/0008-5472.22364177.v1
https://doi.org/10.1158/0008-5472.22364177.v1