Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Paul V. Murphy"'
Autor:
Arvind Negi, Paul V. Murphy
Publikováno v:
Chemistry, Vol 4, Iss 3, Pp 983-1009 (2022)
The human myeloid leukemia cell differentiation protein (hMcl-1) is an anti-apoptotic multi-partner protein, belonging to the B-cell lymphoma-2 (Bcl-2) family of proteins. Studies have linked hMcl-1 alleviated expression with resistance to hemopoieti
Externí odkaz:
https://doaj.org/article/a2e85947064f4787ae809f9564a6829a
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Seasonal periodic pandemics and epidemics caused by Influenza A viruses (IAVs) are associated with high morbidity and mortality worldwide. They are frequent and unpredictable in severity so there is a need for biophysical platforms that can be used t
Externí odkaz:
https://doaj.org/article/2c92a0659dfa4e02bf1658fb23bfca5d
Publikováno v:
Molbank, Vol 2022, Iss 1, p M1337 (2022)
Treatment of N-acetylneuraminic acid with excess base in the presence of benzyl bromide gives a polyhydroxylated 1,4 lactone which after acetylation gave the title compound in 20% overall yield. The structure of the product was confirmed by single cr
Externí odkaz:
https://doaj.org/article/53866e243bcc486f8becbac27e3c17ef
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100253- (2022)
Methods for the synthesis of amides are extremely important given huge prevalence of this functional group in biological systems, as well as in the pharmaceutical industry. The ACS Green Chemistry Institute Pharmaceutical Roundtable have identified t
Externí odkaz:
https://doaj.org/article/b179a333d31645ffa1bfc40dc46734c0
Publikováno v:
Molbank, Vol 2021, Iss 3, p M1262 (2021)
The alkene functionalised 2-aminobenzimidazole ring found in terrazoanthine natural products was synthesized in 3 steps from 1,2-epoxy-4-vinylcyclohexane via epoxide ring opening with toluenesulphonamide yielding 2 regioisomeric, separable amino alco
Externí odkaz:
https://doaj.org/article/e54898dd6ea04ea2a20f6f29bfcada36
Autor:
Paul V. Murphy, Antonio Romero, Qi Xiao, Anna-Kristin Ludwig, Srinivas Jogula, Nadezhda V. Shilova, Tanuja Singh, Adele Gabba, Bilal Javed, Dapeng Zhang, Francisco J. Medrano, Herbert Kaltner, Jürgen Kopitz, Nicolai V. Bovin, Albert M. Wu, Michael L. Klein, Virgil Percec, Hans-Joachim Gabius
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101919- (2021)
Summary: The small 3-O-sulfated galactose head group of sulfatides, an abundant glycosphingolipid class, poses the (sphinx-like) riddle on involvement of glycan bridging by tissue lectins (sugar code). First, synthesis of head group derivatives for f
Externí odkaz:
https://doaj.org/article/a0046aeb444a470d8b22c9dce74afb36
Autor:
Jack Bennett, Paul V. Murphy
Publikováno v:
Molbank, Vol 2020, Iss 2, p M1140 (2020)
(2S,3R,6R)-2-[(R)-1-Hydroxyallyl]-4,4-dimethoxy-6-methyltetrahydro-2H-pyran-3-ol was isolated in 18% after treating the glucose derived (5R,6S,7R)-5,6,7-tris[(triethylsilyl)oxy]nona-1,8-dien-4-one with (1S)-(+)-10-camphorsulfonic acid (CSA). The one-
Externí odkaz:
https://doaj.org/article/448bbba3ef864b979de0a65539ba1623
Publikováno v:
Molecules, Vol 20, Iss 2, Pp 1788-1823 (2015)
The view on the significance of the presence of glycans in glycoconjugates is undergoing a paradigmatic change. Initially mostly considered to be rather inert and passive, the concept of the sugar code identifies glycans as highly versatile platform
Externí odkaz:
https://doaj.org/article/9f23d8b63cde495f96979b2e1dec31ee
Publikováno v:
Molbank, Vol 2017, Iss 1, p M935 (2017)
Methyl 2,3,6-tri-O-benzoyl-4-O-(tert-butyldimethylsilyl)-β-d-galactopyranoside was synthesized in 47% yield by the silylation of a partially benzoylated galactose derivative, prepared from methyl β-d-galactopyranoside. The product was characterized
Externí odkaz:
https://doaj.org/article/c678bfd70400488383eea06bccae3cb8
Publikováno v:
Molecules, Vol 18, Iss 9, Pp 11198-11218 (2013)
Analogues of glycolipids from Spingomonadacaece with O- and S- and SO2-linkages have been prepared using chelation induced anomerisation promoted by TiCl4. Included are examples of the anomerisation of intermediates with O- and S-glycosidic linkages
Externí odkaz:
https://doaj.org/article/8a30220f76a04bb79c6328351b53bf25