Zobrazeno 1 - 10
of 579
pro vyhledávání: '"Paul V. Bernhardt"'
Publikováno v:
Marine Drugs, Vol 22, Iss 6, p 243 (2024)
Subjecting the Australian marine-derived fungus Aspergillus noonimiae CMB-M0339 to cultivation profiling using an innovative miniaturized 24-well plate format (MATRIX) enabled access to new examples of the rare class of 2,6-diketopiperazines, noonazi
Externí odkaz:
https://doaj.org/article/d71ed68479be46919e770be6c4fd96d6
Autor:
Jason K. Cullen, Glen M. Boyle, Pei-Yi Yap, Stefan Elmlinger, Jacinta L. Simmons, Natasa Broit, Jenny Johns, Blake Ferguson, Lidia A. Maslovskaya, Andrei I. Savchenko, Paul Malek Mirzayans, Achim Porzelle, Paul V. Bernhardt, Victoria A. Gordon, Paul W. Reddell, Alberto Pagani, Giovanni Appendino, Peter G. Parsons, Craig M. Williams
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The long-standing perception of Protein Kinase C (PKC) as a family of oncoproteins has increasingly been challenged by evidence that some PKC isoforms may act as tumor suppressors. To explore the hypothesis that activation, rather than inhib
Externí odkaz:
https://doaj.org/article/48af2e8d91fb499798d2ad925238a5a8
Autor:
Luiz G. F. Lopes, Peter J. Sadler, Vânia Bernardes-Génisson, José J. G. Moura, Remi Chauvin, Paul V. Bernhardt, Eduardo H. S. Sousa
Publikováno v:
Química Nova, Vol 43, Iss 8, Pp 1176-1189 (2020)
During the last 150 years or more, society has witnessed many key scientific discoveries and inventions, which have dramatically improved not only our quality of life, but our lifespan. However, the motivation of scientists to provide scientific adva
Externí odkaz:
https://doaj.org/article/769d08b0755945cfa9113712b07f7dd7
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 10, Pp 1653-1656 (2020)
Short syntheses to high Fsp3 index natural-product analogues such as iminosugars are of paramount importance in the investigation of their biological activities and reducing the use of protecting groups is an advantageous synthetic strategy. An isopr
Externí odkaz:
https://doaj.org/article/0cd40a45bdcf4bc29ce35f350d57555e
Publikováno v:
Molecules, Vol 27, Iss 24, p 9066 (2022)
This study showcases the application of an integrated workflow of molecular networking chemical profiling (GNPS), together with miniaturized microbioreactor cultivation profiling (MATRIX) to successfully detect, dereplicate, prioritize, optimize the
Externí odkaz:
https://doaj.org/article/5473d0ebd67c4e9ba977b104c692db6e
Publikováno v:
Marine Drugs, Vol 20, Iss 11, p 698 (2022)
Analytical scale chemical/cultivation profiling prioritized the Australian marine-derived fungus Aspergillus noonimiae CMB-M0339. Subsequent investigation permitted isolation of noonindoles A–F (5–10) and detection of eight minor analogues (i–v
Externí odkaz:
https://doaj.org/article/a78ff1075af242d5b4f143fd61a8c894
Autor:
David M. Campkin, Yuna Shimadate, Barbara Bartholomew, Paul V. Bernhardt, Robert J. Nash, Jennette A. Sakoff, Atsushi Kato, Michela I. Simone
Publikováno v:
Molecules, Vol 27, Iss 11, p 3447 (2022)
Tetrachlorinated phthalimide analogues bearing a boron-pinacolate ester group were synthesised via two synthetic routes and evaluated in their glycosidase modulating and anticancer properties, with a view to use them in boron neutron capture therapy
Externí odkaz:
https://doaj.org/article/1e9051f89d4a4d5ab3a4f314e45666c7
Publikováno v:
Marine Drugs, Vol 17, Iss 8, p 475 (2019)
Chemical analysis of a cultivation of an Australian Mugil mullet gastrointestinal tract (GIT) derived fungus, Scopulariopsis sp. CMB-F458, yielded the known lipodepsipeptides scopularides A (1) and B (2). A comparative global natural product social (
Externí odkaz:
https://doaj.org/article/d2ef75e6ed0d4d7eb97965caf03cc2a9
Publikováno v:
Biotechnology for Biofuels, Vol 10, Iss 1, Pp 1-2 (2017)
Externí odkaz:
https://doaj.org/article/8c51f3de25094db4ad1e3cf0899f8fda
Autor:
Xiuli Xu, Haijin Yang, Zeinab G. Khalil, Liyuan Yin, Xue Xiao, Pratik Neupane, Paul V. Bernhardt, Angela A. Salim, Fuhang Song, Robert J. Capon
Publikováno v:
Marine Drugs, Vol 15, Iss 12, p 374 (2017)
This study describes an investigation into secondary metabolites that are produced by a marine red alga, Symphyocladia latiuscula, which was collected from coastal waters off Qingdao, China. A combination of normal, reversed phase, and gel chromatogr
Externí odkaz:
https://doaj.org/article/ab498f3d7d5d4953b9daf288fca4d41b